2017
DOI: 10.1016/j.ijcard.2016.11.205
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TRPV1 channels in cardiovascular system: A double edged sword?

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Cited by 49 publications
(46 citation statements)
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“…A possibility of mechanical effects from the interaction of the AMF and the MNPs can be ruled out as the energies and forces necessary to excite mechanosensitive ion channels exceed those that can be generated for the MNP dimensions and AMF conditions used in our study by orders of magnitude (text S4). TRPV1 (and other heat-sensitive TRP channels) were shown to be expressed in other organs deep within the body such as the peripheral nerves, gastrointestinal tract (38), pancreas, (39) and heart (40), suggesting potential applications for magnetothermal deep organ stimulation as means to study organ function and pave the way to development of bioelectronic medicines.…”
Section: Discussionmentioning
confidence: 99%
“…A possibility of mechanical effects from the interaction of the AMF and the MNPs can be ruled out as the energies and forces necessary to excite mechanosensitive ion channels exceed those that can be generated for the MNP dimensions and AMF conditions used in our study by orders of magnitude (text S4). TRPV1 (and other heat-sensitive TRP channels) were shown to be expressed in other organs deep within the body such as the peripheral nerves, gastrointestinal tract (38), pancreas, (39) and heart (40), suggesting potential applications for magnetothermal deep organ stimulation as means to study organ function and pave the way to development of bioelectronic medicines.…”
Section: Discussionmentioning
confidence: 99%
“…17 Moreover, also in animals, TRPV1 activation has been shown to stimulate the release of calcitonin gene-related peptide (CGRP), a potent endogenous vasodilator, 18 which in turn enhances Na + excretion and nitric oxide (NO) release in endothelial cells. 19 Thus, it appears that in animals capsaicin possesses vasodilatory 18 and anti-vasoconstrictive action. 19 Despite the possible cardioprotective effects of capsaicin and its popularity as analgesic, yet to date no study has elucidated whether TRPV1 stimulation has any effect on humans' blood pressure regulation.…”
Section: Introductionmentioning
confidence: 99%
“…19 Thus, it appears that in animals capsaicin possesses vasodilatory 18 and anti-vasoconstrictive action. 19 Despite the possible cardioprotective effects of capsaicin and its popularity as analgesic, yet to date no study has elucidated whether TRPV1 stimulation has any effect on humans' blood pressure regulation.…”
Section: Introductionmentioning
confidence: 99%
“…Nowadays, TRP family has been classified into six subfamilies including vanilloid (TRPV), canonical (TRPC), melastatin (TRPM), polycystin (TRPP), mucoloipin (TRPML) and ankyrin (TRPA), depending on the sequence of amino acids homology [23]. TRPV1 was believed to have various distributions in organs including heart, liver, lungs, kidney, intestine, brain, uterus, testis, salivary glands, dorsal root ganglia, and sensory neurons [16,24,25].…”
Section: Discussionmentioning
confidence: 99%