TRPV1 channels in cardiovascular system: A double edged sword?

Randhawa, Puneet Kaur; Jaggi, Amteshwar Singh

doi:10.1016/j.ijcard.2016.11.205

Cited by 49 publications

(46 citation statements)

References 69 publications

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“…A possibility of mechanical effects from the interaction of the AMF and the MNPs can be ruled out as the energies and forces necessary to excite mechanosensitive ion channels exceed those that can be generated for the MNP dimensions and AMF conditions used in our study by orders of magnitude (text S4). TRPV1 (and other heat-sensitive TRP channels) were shown to be expressed in other organs deep within the body such as the peripheral nerves, gastrointestinal tract (38), pancreas, (39) and heart (40), suggesting potential applications for magnetothermal deep organ stimulation as means to study organ function and pave the way to development of bioelectronic medicines.…”

Section: Discussionmentioning

confidence: 99%

Transgene-free remote magnetothermal regulation of adrenal hormones

et al. 2020

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The field of bioelectronic medicines seeks to modulate electrical signaling within peripheral organs, providing temporally precise control of physiological functions. This is usually accomplished with implantable devices, which are often unsuitable for interfacing with soft and highly vascularized organs. Here, we demonstrate an alternative strategy for modulating peripheral organ function, which relies on the endogenous expression of a heat-sensitive cation channel, transient receptor potential vanilloid family member 1 (TRPV1), and heat dissipation by magnetic nanoparticles (MNPs) in remotely applied alternating magnetic fields. We use this approach to wirelessly control adrenal hormone secretion in genetically intact rats. TRPV1-dependent calcium influx into the cells of adrenal cortex and medulla is sufficient to drive rapid release of corticosterone and (nor)epinephrine. As altered levels of these hormones have been correlated with mental conditions such as posttraumatic stress disorder and major depression, our approach may facilitate the investigation of physiological and psychological impacts of stress.

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Section: Discussionmentioning

confidence: 99%

Transgene-free remote magnetothermal regulation of adrenal hormones

et al. 2020

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“…17 Moreover, also in animals, TRPV1 activation has been shown to stimulate the release of calcitonin gene-related peptide (CGRP), a potent endogenous vasodilator, 18 which in turn enhances Na + excretion and nitric oxide (NO) release in endothelial cells. 19 Thus, it appears that in animals capsaicin possesses vasodilatory 18 and anti-vasoconstrictive action. 19 Despite the possible cardioprotective effects of capsaicin and its popularity as analgesic, yet to date no study has elucidated whether TRPV1 stimulation has any effect on humans' blood pressure regulation.…”

Section: Introductionmentioning

confidence: 99%

“…19 Thus, it appears that in animals capsaicin possesses vasodilatory 18 and anti-vasoconstrictive action. 19 Despite the possible cardioprotective effects of capsaicin and its popularity as analgesic, yet to date no study has elucidated whether TRPV1 stimulation has any effect on humans' blood pressure regulation.…”

Section: Introductionmentioning

confidence: 99%

Effects of capsaicin application on the skin during resting exposure to temperate and warm conditions

Botonis

Miliotis

Kounalakis

et al. 2018

Scandinavian Med Sci Sports

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We investigated thermoregulatory and cardiovascular responses at rest in a temperate (20°C) and in a warm (30°C) environment (40% RH) without and with the application of capsaicin on the skin. We hypothesized that regardless of environmental temperature, capsaicin application would stimulate heat loss and concomitantly deactivate heat conservation mechanisms, thus resulting in rectal temperature (Tre) and mean blood pressure decline due to excitation of heat‐sensitive TRPV1. Ten male subjects were exposed, while seated, for 30 minutes to 20.8 ± 1.0°C or to 30.6 ± 1.1°C: without (NCA) and with (CA) application of capsaicin patches on the skin. Thermoregulatory (Tre, proximal‐distal skin temperature gradient) and cardiovascular variables (modelflow technique) as well as oxygen uptake were continuously measured. The area under the curve for Tre decline at 20°C was smaller in CA (−2.1 ± 1.3 a.u.) than in NCA (−0.6 ± 1.1 a.u., P < 0.01, r = 0.8). Likewise, at 30°C it was smaller in CA (−2.2 ± 2.1 a.u.) compared to NCA (−0.8 ± 2.0 a.u., P = 0.02, r = 0.7). Local vasomotor tone and oxygen uptake, were significantly lower by 36.7% ± 94.2% and 12.3% ± 12.3%, respectively, with capsaicin compared to NCA (P = 0.05 and P < 0.01, respectively). Additionally, in 30°C CA mean arterial pressure was lower by 10.7% ± 5.9%, 8.9% ± 5.9%, and 10.6% ± 7.0% compared to 30°C NCA, 20°C NCA, and 20°C CA, respectively (P < 0.01, P = 0.02, and P < 0.01, respectively, d = 1.4‐1.8). In conclusion, capsaicin application on the skin induced vasodilation and Tre decline. At 30°C CA, thermal responses were accompanied by arterial hypotension most likely due to the interactive effects of both stressors (warm environment and capsaicin) on cutaneous vascular regulation.

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“…Nowadays, TRP family has been classified into six subfamilies including vanilloid (TRPV), canonical (TRPC), melastatin (TRPM), polycystin (TRPP), mucoloipin (TRPML) and ankyrin (TRPA), depending on the sequence of amino acids homology [23]. TRPV1 was believed to have various distributions in organs including heart, liver, lungs, kidney, intestine, brain, uterus, testis, salivary glands, dorsal root ganglia, and sensory neurons [16,24,25].…”

Section: Discussionmentioning

confidence: 99%

TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm

Wang

Jia

2020

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The natural outcome of abdominal aortic aneurysm (AAA) is that of slow progression and ultimate rupture, then a life-threatening hemorrhage consequently. Ruptured AAA is a dramatic catastrophe and constitutes one of the leading causes of acute death in elderly men. However, the mechanism of AAA is still unclear. Transient receptor potential vanilloid (TRPV) family has protective effects in cardiovascular diseases. In this study, we revealed the expression and the pathogenesis of TRPV1 in a mouse AAA model. The results presented here identify TRPV1 could be a potential therapeutic target for AAA treatment. ARTICLE HISTORY

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TRPV1 channels in cardiovascular system: A double edged sword?

Cited by 49 publications

References 69 publications

Transgene-free remote magnetothermal regulation of adrenal hormones

Transgene-free remote magnetothermal regulation of adrenal hormones

Effects of capsaicin application on the skin during resting exposure to temperate and warm conditions

TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm

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