TRPV1, CGRP and SP in scalp arteries of patients suffering from chronic migraine

Fiacco, M. Del; Quartu, Marina; Boi, Marianna; Serra, Maria Pina; Melis, Tiziana; Boccaletti, Riccardo; Shevel, Elliot; Cianchetti, Carlo

doi:10.1136/jnnp-2014-308813

Cited by 51 publications

(38 citation statements)

References 26 publications

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“…In accordance with this, clinical findings report that TRPV1 receptor plays a role in pain and hyperalgesia associated with inflammation, injury, acidosis and cancer (Holzer, 2008). As regards the trigeminal system, a positive correlation between TRPV1-LI sensory afferents and pain score has been shown in dental pain (Morgan et al 2005) and chronic burning mouth syndrome (Yilmaz et al 2007), and we detected an increased density of the TRPV1-LI vascular innervation of scalp arteries in chronic migraine (Del Fiacco et al 2015). The percentage of the TRPV1-positive neurons we detected in the adult TG is double the percentage that was previously reported by Hou et al (2002).…”

Section: Discussionsupporting

confidence: 90%

“…This warns against the extrapolation of data obtained from experimental animals and requires the acquisition of specific knowledge of human regional chemical neuroanatomy. Regarding the localization of the TRPV1 receptor in the human trigeminal somatosensory system, the available information pertains, to the best of our knowledge, to the TG neurons (Hou et al 2002) and to certain territories of their peripheral innervation (Morgan et al 2005;Yilmaz et al 2007;Del Fiacco et al 2015). With a view to contributing to the characterization of the capsaicin-sensitive component of the human trigeminal sensory system, we present new data here concerning the immunohistochemical occurrence of the TRPV1 receptor in autoptic specimens of the human TG and spinal trigeminal nucleus, and we compare this with that of CGRP and SP.…”

Section: Introductionmentioning

confidence: 99%

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TRPV1 receptor in the human trigeminal ganglion and spinal nucleus: immunohistochemical localization and comparison with the neuropeptides CGRP and SP

et al. 2016

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This work presents new data concerning the immunohistochemical occurrence of the transient receptor potential vanilloid type-1 (TRPV1) receptor in the human trigeminal ganglion (TG) and spinal nucleus of subjects at different ontogenetic stages, from prenatal life to postnatal old age. Comparisons are made with the sensory neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP). TRPV1-like immunoreactive (LI) material was detected by western blot in homogenates of TG and medulla oblongata of subjects at prenatal and adult stages of life. Immunohistochemistry showed that expression of the TRPV1 receptor is mostly restricted to the small- and medium-sized TG neurons and to the caudal subdivision of the spinal trigeminal nucleus (Sp5C). The extent of the TRPV1-LI TG neuronal subpopulation was greater in subjects at early perinatal age than at late perinatal age and in postnatal life. Centrally, the TRPV1 receptor localized to fibre tracts and punctate elements, which were mainly distributed in the spinal tract, lamina I and inner lamina II of the Sp5C, whereas stained cells were rare. The TRPV1 receptor colocalized partially with CGRP and SP in the TG, and was incompletely codistributed with both neuropeptides in the spinal tract and in the superficial laminae of the Sp5C. Substantial differences were noted with respect to the distribution of the TRPV1-LI structures described in the rat Sp5C and with respect to the temporal expression of the receptor during the development of the rat spinal dorsal horn. The distinctive localization of TRPV1-LI material supports the concept of the involvement of TRPV1 receptor in the functional activity of the protopathic compartment of the human trigeminal sensory system, i.e. the processing and neurotransmission of thermal and pain stimuli.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

TRPV1 receptor in the human trigeminal ganglion and spinal nucleus: immunohistochemical localization and comparison with the neuropeptides CGRP and SP

et al. 2016

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“…Of interest, increased TRPV1, CGRP, and SP expression levels are correlated with patients suffering from chronic migraines. 42,43 TRPV1 antagonists have also been evaluated in the treatment of this disorder 44 . Of direct relevance to our research, a significant percentage of military veterans with blast-related injuries and confirmed TBI have also been diagnosed with migraine headaches and/or chronic, daily headaches 45 .…”

Section: Discussionmentioning

confidence: 98%

Low-Level Blast Exposure Increases Transient Receptor Potential Vanilloid 1 (TRPV1) Expression in the Rat Cornea

Por

Choi

Lund

2016

Current Eye Research

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Background: Blast-related ocular injuries sustained by military personnel have led to rigorous efforts to elucidate the effects of blast exposure on neurosensory function. Recent studies have provided some insight into cognitive and visual deficits sustained following blast exposure; however, limited data are available on the effects of blast on pain and inflammatory processes. Investigation of these secondary effects of blast exposure is necessary to fully comprehend the complex pathophysiology of blast-related injuries. The overall purpose of this study is to determine the effects of single and repeated blast exposure on pain and inflammatory mediators in ocular tissues. Methods: A compressed air shock tube was used to deliver a single or repeated blast (68.0 ± 2.7 kPa) to anesthetized rats daily for 5 days. Immunohistochemistry was performed on ocular tissues to determine the expression of the transient receptor potential vanilloid 1 (TRPV1) channel, calcitonin gene-related peptide (CGRP), substance P (SP), and endothelin-1 (ET-1) following single and repeated blast exposure. Neutrophil infiltration and myeloperoxidase (MPO) expression were also assessed in blast tissues via immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) analysis, respectively. Results: TRPV1 expression was increased in rat corneas exposed to both single and repeated blast. Increased secretion of CGRP, SP, and ET-1 was also detected in rat corneas as compared to control. Moreover, repeated blast exposure resulted in neutrophil infiltration in the cornea and stromal layer as compared to control animals. Conclusion: Single and repeated blast exposure resulted in increased expression of TRPV1, CGRP, SP, and ET-1 as well as neutrophil infiltration. Collectively, these findings provide novel insight into the activation of pain and inflammation signaling mediators following blast exposure.

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“…''TRPA1 is emerging as a major contributing pathway in migraine'' and ''TRPA1 is also implicated in the pathogenesis of asthma'' (Benemei et al, 2014(Benemei et al, , p. 2552Deering-Rice et al, 2015, p. 893). TRPV1-like immunoreactive innervention was increased in the scalp arteries of migraineurs, and TRPV1 expression was increased in nasal mucosa in idiopathic rhinitis (Del Fiacco et al, 2015;Van Gerven et al, 2014). In some children with asthma, gene polymorphisms for TRPA1 were associated with reduced asthma control (Deering-Rice et al, 2015).…”

Section: Trpa1 and Trpv1mentioning

confidence: 99%

A Comparison of Multiple Chemical Sensitivity with Other Hypersensitivity Illnesses Suggests Evidence and a Path to Answers

Dennison¹

2017

Ecopsychology

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Throughout history, when doctors and scientists have encountered illnesses that were not clearly visible and didn't have an obvious explanation, those illnesses have often been dismissed as either not real or as psychological. Asthma was among the illnesses once thought to be psychological. In order for doctors and researchers to reach similar conclusions about multiple chemical sensitivity, they have had to overlook a great deal of valuable evidence including the signs and symptoms of patients as well as the commonalities this illness shares with other now well-recognized hypersensitivity illnesses. Researching the relationship between multiple chemical sensitivity and other hypersensitivity illnesses may help narrow down the potential mechanisms in this illness and bring answers to patients, which might ease the burden of having an illness that is once again unrecognized by the people patients are most dependent on for help.

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TRPV1, CGRP and SP in scalp arteries of patients suffering from chronic migraine

Cited by 51 publications

References 26 publications

TRPV1 receptor in the human trigeminal ganglion and spinal nucleus: immunohistochemical localization and comparison with the neuropeptides CGRP and SP

TRPV1 receptor in the human trigeminal ganglion and spinal nucleus: immunohistochemical localization and comparison with the neuropeptides CGRP and SP

Low-Level Blast Exposure Increases Transient Receptor Potential Vanilloid 1 (TRPV1) Expression in the Rat Cornea

A Comparison of Multiple Chemical Sensitivity with Other Hypersensitivity Illnesses Suggests Evidence and a Path to Answers

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