Trpv1 and Trpa1 are not essential for Psickle-like activity in red cells of the SAD mouse model of sickle cell disease

Piezo1 activation augments sickling propensity and the adhesive properties of sickle red blood cells in a calcium‐dependent manner

“…This increased Ca 2+ influx, also known as P sickle , is considered to be the manifestation of a non-selective cation conductance for monovalent and divalent cations such as Na + , K + , Rb + , Ca 2+ and Mg 2+ . [5][6][7] At this time, the protein (or proteins) that mediates P sickle has not been identified, but the inhibitory effect of Grammastola spatulata mechanotoxin-4 (GsMTx4) suggests that P sickle could be a mechanosensitive protein, 8,9 and it has been proposed that Piezo1 could be a good candidate for P sickle . 8,10,11 Piezo1 (also known as FAM38A) is a protein with mechanosensitive properties that is involved in the cellular influx of calcium (Ca 2+ ).…”