Abstract:Astrocytes exhibit spatially-restricted near membrane microdomain Ca 2+ transients in their fine processes. How these transients are generated, and how they regulate brain function in vivo remain unclear. Here we show that Drosophila astrocytes exhibit spontaneous, activity-independent microdomain Ca 2+ transients in their fine processes.Astrocyte microdomain Ca 2+ transients are mediated by the TRP channel TrpML, stimulated by reactive oxygen species (ROS), and can be enhanced in frequency by tyramine via the… Show more
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