TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes

Sahni, Jaya; Tamura, Ryuichi; Sweet, Ian R.; Scharenberg, Andrew M.

doi:10.4161/cc.9.17.12798

Cited by 72 publications

(64 citation statements)

References 33 publications

(36 reference statements)

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“…could rescue the phenotype [71]. TRPM7-deficient cells downregulated molecules involved in the PI3K/Akt/mTOR signaling pathway, resulting in cell cycle arrest when cells were not supplemented with Mg 2?…”

Section: The Regulators Of Mg 21 Homeostasis: Trpm6 and Trpm7mentioning

confidence: 98%

The role of Mg2+ in immune cells

et al. 2012

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The physiological and clinical relevance of Mg(2+) has evolved over the last decades. The molecular identification of multiple Mg(2+) transporters (Acdp2, MagT1, Mrs2, Paracellin-1, SLC41A1, SLC41A2, TRPM6 and TRPM7) and their biophysical characterization in recent years has improved our understanding of Mg(2+) homeostasis regulation and has provided a basis for investigating the role of Mg(2+) in the immune system. Deletions and mutations of Mg(2+) transporters produce severe phenotypes with more systemic symptoms than those seen with Ca(2+) channel deletions, which tend to be more specific and less profound. Deficiency of the Mg(2+) permeable ion channels TRPM6 or TRPM7 in mice is lethal at embryonic day 12.5 or at day 6.5, respectively, and, even more surprisingly, chicken DT40 B cells lacking TRPM7 die after 24-48 h. Recent progress made in Mg(2+) research has helped to define underlying mechanisms of two hereditary diseases, human Hypomagnesemia (TRPM6 deletion) and X-chromosomal immunodeficiency (MagT1 deletion), and has revealed a potential new role for Mg(2+) as a second messenger. Future elucidation of human Mg(2+) transporters (Mrs2, SLC41A1, SLC41A2, TRPM7) expressed in immunocytes, beyond MagT1 and TRPM6, will widen our knowledge about the potential role of Mg(2+) in the activation of the immune response.

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Section: The Regulators Of Mg 21 Homeostasis: Trpm6 and Trpm7mentioning

confidence: 98%

The role of Mg2+ in immune cells

et al. 2012

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“…Supporting evidence for this conclusion was provided by experiments in Xenopus oocytes which allowed direct injection and measurement of free Mg 2+ (Horowitz and Tluczek, 1989). However, there was a failure to demonstrate an increase in free Mg 2+ by indicator measurements in activated lymphocytes (Rink et al, 1982), despite the reported increase in total Mg 2+ (Sahni et al, 2010). It should be noted that although Mg 2+ is a co--factor in all phosphoryl transfers in cells, the actual regulatory substrate is MgATP 2--in which the Mg 2+ is chelated by ATP 4--, and therefore would not be registered by indicators of free Mg 2+ .…”

Section: Loss Of Mgmentioning

confidence: 99%

Magnesium in the Central Nervous System

Vink

Nechifor

2011

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This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesium's involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior.

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“…In order to reliably produce a change of intracellular Mg 2+ over a wide range, it was necessary to drastically lower the concentration of Ca 2+ in the medium while varying the extracellular concentration of Mg 2+ . (Rink et al, 1982), despite the reported increase in total Mg 2+ (Sahni et al, 2010). It should be noted that although Mg 2+ is a co--factor in all phosphoryl transfers in cells, the actual regulatory substrate is MgATP 2--in which the Mg 2+ is chelated by ATP 4--, and therefore would not be registered by indicators of free Mg 2+ .…”

Section: Discussionmentioning

confidence: 99%

“…Total Mg 2+ in the TRPM7--deficient lymphocytes in standard medium underwent a significant decrease, but no change in free Mg 2+ was detected, which contrasts with the increase in free Mg 2+ in mitogen--stimulated fibroblasts (Ishijima et al, 1991) and in myocytes (Grubbs, 1991). A number of the known properties of quiescent, ex--vivo lymphocytes were also measured in the TRPM7--deficient lymphocytes in standard medium containing 0.4 mM Mg 2+ (Sahni et al, 2010). The DNA content and size of the two cell sources were similar, and suggested that TRPM7 and Mg 2+ are involved in the activation of normal quiescent lymphocytes.…”

Section: Role Of Mg 2+ In Regulating Uridine Uptakementioning

confidence: 99%

“…This issue has recently been reappraised. The expression of TRPM7 and, therefore, the capability of the cells to take up Mg has been associated with the transition from a quiescent to a proliferative metabolic state in which it is aerobic glycolysis that generates the energy necessary for cell growth (Sahni et al, 2010).…”

Section: The Impact Of Extracellular Mg On Tumour Cellsmentioning

confidence: 99%

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