TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway

Meng, Xiang‐Jin; Cheng, Can; Wu, Jiguo; Cai, Shaoxi; Ye, Changsheng; Chen, Haiyang; Yang, Zhonghua; Zeng, Hongqiang; Shen, Qiang; Zou, Fei

doi:10.1016/j.canlet.2013.01.031

Cited by 134 publications

(118 citation statements)

References 54 publications

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“…TRPM7 is critical for cell migration of different cell cancer models such as breast cancer, lung cancer, nasopharingeal cancer, and pancreatic ductal adrenocarcinoma [197][198][199][200][201]. It has been observed that TRPM7 is tightly regulated by the plasma membrane phospholipid PIP 2 : stimulation of PLC-coupled GPCRs causes depletion of membrane PIP 2 and, subsequently, inactivation of TRPM7 currents which could protect from the development of related cancer diseases.…”

Section: Cancermentioning

confidence: 98%

Lipids as central modulators of sensory TRP channels

Ciardo

Ferrer-Montiel

2017

Biochimica et Biophysica Acta (BBA) - Biomembranes

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The transient receptor potential (TRP) ion channel family is involved in a diversity of physiological processes including sensory and homeostatic functions, as well as muscle contraction and vasomotor control. Their dysfunction contributes to the etiology of several diseases, being validated as therapeutic targets. These ion channels may be activated by physical or chemical stimuli and their function is highly influenced by signaling molecules activated by extracellular signals. Notably, as integral membrane proteins, lipid molecules also modulate their membrane location and function either by direct interaction with the channel structure or by modulating the physico-chemical properties of the cellular membrane. This lipid-based modulatory effect is being considered an alternative and promising approach to regulate TRP channel dysfunction in diseases. Here, we review the current progress in this exciting field highlighting a complex channel regulation by a large diversity of lipid molecules and suggesting some diseases that may benefit from a membrane lipid therapy. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá.

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Section: Cancermentioning

confidence: 98%

Lipids as central modulators of sensory TRP channels

Ciardo

Ferrer-Montiel

2017

Biochimica et Biophysica Acta (BBA) - Biomembranes

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“…However, one study found that mitogenactivated protein kinase (MAPK) signaling pathways are involved in the TRPM7-mediated migration and invasion of MDA-MB-435 breast cancer cells. Silencing of TRPM7 caused a significant reduction in the migration and invasion potential of MDA-MB-435 breast cancer cells in addition to a decrease in the levels of phosphorylated Src and MAPK (29,30).…”

Section: Trp Channels and Breast Cancermentioning

confidence: 99%

Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer

Chen

Luan

et al. 2014

BST

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“…TRPM7 is also involved in migration and metastasis development in breast cancer cells, but this role is due to its kinase activity (MAPK pathway activation and regulation of cells adhesion) in a calcium-independent fashion [84,85].…”

Section: Calcium Channels Migration and Metastasis In Breast Cancermentioning

confidence: 99%

Plasma membrane calcium channels in cancer: Alterations and consequences for cell proliferation and migration

Déliot

Constantin

2015

Biochimica et Biophysica Acta (BBA) - Biomembranes

156

140

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The study of calcium channels in molecular mechanisms of cancer transformation is still a novel area of research. Several studies, mostly conducted on cancer cell lines, however support the idea that a diversity of plasma membrane channels participates in the remodeling of Ca2+ homeostasis, which regulates various cancer hallmarks such as uncontrolled multiplication and increase in migration and invasion abilities. However few is still understood concerning the intracellular signaling cascades mobilized by calcium influx participating to cancer cell behavior. This review intends to gather some of these pathways dependent on plasma membrane calcium channels and described in prostate, breast and lung cancer cell lines. In these cancer cell types, the calcium channels involved in calcium signaling pathways promoting cancer behaviors are mostly non-voltage activated calcium channels and belong to the TRP superfamily (TRPC, TPRPV and TRPM families) and the Orai family. TRP and Orai channels are part of many signaling cascades involving the activation of transmembrane receptors by extracellular ligand from the tumor environment. TRPV can sense changes in the physical and chemical environment of cancer cells and TRPM7 are stretch activated and sensitive to cholesterol. Changes in activation and or expression of plasma-membrane calcium channels affect calcium-dependent signaling processes relevant to tumorigenesis. The studies cited in this review suggest that an increase in plasma membrane calcium channel expression and/or activity sustain an elevated calcium entry (constitutive or under the control of extracellular signals) promoting higher cell proliferation and migration in most cases. A variety of non-voltage-operated calcium channels display change expression and/or activity in a same cancer type and cooperate to the same process relevant to cancer cell behavior, or can be involved in a different sequence of events during the tumorigenesis. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.

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TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway

Cited by 134 publications

References 54 publications

Lipids as central modulators of sensory TRP channels

Lipids as central modulators of sensory TRP channels

Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer

Plasma membrane calcium channels in cancer: Alterations and consequences for cell proliferation and migration

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