TRPM7 is overexpressed in bladder cancer and promotes proliferation, migration, invasion and tumor growth

Gao, Shenglin; Kong, Chuize; Zhang, Zhe; Li, Zeliang; Bi, Jianbin; Liu, Xiankui

doi:10.3892/or.2017.5883

Cited by 39 publications

(32 citation statements)

References 27 publications

(28 reference statements)

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“…In the context of metastasis, TRPM7, a Ca 2+ -nonselective cation channel carrying -kinase domain (56), appears to be the best studied TRP channel so far. TRPM7 regulates several events in cell motility such as polarization (57), adhesion (58,59) and migration (60). We summarize the representative signaling mechanisms underlying the function of specific TRP channels, in Fig.…”

Section: Trp Channels In Cancer Metastasismentioning

confidence: 99%

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Emerging role of transient receptor potential (TRP) channels in cancer progression

Yang

Kim

2020

BMB Rep.

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Transient receptor potential (TRP) channels comprise a diverse family of ion channels, the majority of which are calcium permeable and show sophisticated regulatory patterns in response to various environmental cues. Early studies led to the recognition of TRP channels as environmental and chemical sensors. Later studies revealed that TRP channels mediated the regulation of intracellular calcium. Mutations in TRP channel genes result in abnormal regulation of TRP channel function or expression, and interfere with normal spatial and temporal patterns of intracellular local Ca 2+ distribution. The resulting dysregulation of multiple downstream effectors, depending on Ca 2+ homeostasis, is associated with hallmarks of cancer pathophysiology, including enhanced proliferation, survival and invasion of cancer cells. These findings indicate that TRP channels affect multiple events that control cellular fate and play a key role in cancer progression. This review discusses the accumulating evidence supporting the role of TRP channels in tumorigenesis, with emphasis on prostate cancer. [BMB Reports 2020; 53(3): 125-132]

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Section: Trp Channels In Cancer Metastasismentioning

confidence: 99%

“…In ovarian cancer (72) and bladder cancer, TRPM7 regulates cancer cell migration (60). TRPM7 also regulates proliferation of cancer cells (73)(74)(75), although silencing of TRPM7 does not affect the viability of breast cancer cells (61).…”

Section: Trp Channels In Cancer Metastasismentioning

confidence: 99%

Emerging role of transient receptor potential (TRP) channels in cancer progression

Yang

Kim

2020

BMB Rep.

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“…Also, TRPM7 are overexpressed in pancreatic ductal adenocarcinomas and are associated with lymph node metastases [83]. TRPM7 mRNA and protein are also overexpressed in bladder cancer with respect to normal tissue and are associated with poor prognosis [84]. TRPA1 is overexpressed also in SCLC patients compared with NSCLC and since it is associated with SCLC patients' survival representing a potential therapeutic target [85].…”

Section: Transient Receptor Potential (Trp) Channelsmentioning

confidence: 99%

Ion Channels and Transporters as Cancer Biomarkers and Targets for Diagnostics with Antibodies

Iorio¹,

Duranti²,

Lastraioli³

2021

Translational Research in Cancer

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Cancer is a highly heterogeneous disease in terms of both response to therapy and prognosis. The introduction of molecular tools and antibodies had a great impact on cancer management in recent years for both cancer diagnosis and therapy. Ion channels and transporters (ICT) are membrane proteins aberrantly expressed in several human cancers. ICT can now represent potential cancer biomarkers as well as targets for therapeutic and diagnostic purposes. In particular, we will discuss about the potential role of ICTs as biomarkers for solid cancers (evaluated either by immunohistochemistry or molecular biology techniques) and the potential use of antibodies for diagnosis.

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“…TRPM7 is overexpressed and required for proliferation in bladder cancer [9] and breast cancer cells [10]. TRPM7 channels are permeable to both Ca 2+ and Mg 2+ .…”

Section: Introductionmentioning

confidence: 99%

The Role of Transient Receptor Potential Melastatin 7 (TRPM7) in Cell Viability: A Potential Target to Suppress Breast Cancer Cell Cycle

Liu

Dilger

Lin

2020

Cancers

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The divalent cation-selective channel transient receptor potential melastatin 7 (TRPM7) channel was shown to affect the proliferation of some types of cancer cell. However, the function of TRPM7 in the viability of breast cancer cells remains unclear. Here we show that TRPM inhibitors suppressed the viability of TRPM7-expressing breast cancer cells. We first demonstrated that the TRPM7 inhibitors 2-aminoethyl diphenylborinate (2-APB), ginsenoside Rd (Gin Rd), and waixenicin A preferentially suppressed the viability of human embryonic kidney HEK293 overexpressing TRPM7 (HEK-M7) cells over wildtype HEK293 (WT-HEK). Next, we confirmed the effects of 2-APB on the TRPM7 channel functions by whole-cell currents and divalent cation influx. The inhibition of the viability of HEK-M7 cells by 2-APB was not mediated by the increase in cell death but by the interruption of the cell cycle. Similar to HEK-M7 cells, the viability of TRPM7-expressing human breast cancer MDA-MB-231, AU565, and T47D cells were also suppressed by 2-APB by arresting the cell cycle in the S phase. Furthermore, in a novel TRPM7 knock-out MDA-MB-231 (KO-231) cell line, decreased divalent influx and reduced proliferation were observed compared to the wildtype MDA-MB-231 cells. 2-APB and Gin Rd preferentially suppressed the viability of wildtype MDA-MB-231 cells over KO-231 by affecting the cell cycle in wildtype but not KO-231 cells. Our results suggest that TRPM7 regulates the cell cycle of breast cancers and is a potential therapeutic target.

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TRPM7 is overexpressed in bladder cancer and promotes proliferation, migration, invasion and tumor growth

Cited by 39 publications

References 27 publications

Emerging role of transient receptor potential (TRP) channels in cancer progression

Emerging role of transient receptor potential (TRP) channels in cancer progression

Ion Channels and Transporters as Cancer Biomarkers and Targets for Diagnostics with Antibodies

The Role of Transient Receptor Potential Melastatin 7 (TRPM7) in Cell Viability: A Potential Target to Suppress Breast Cancer Cell Cycle

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