TRPM channels as potential therapeutic targets against pro-inflammatory diseases

Zierler, Susanna; Hampe, Sarah; Nadolni, Wiebke

doi:10.1016/j.ceca.2017.05.002

Cited by 32 publications

(32 citation statements)

References 150 publications

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“…TRPM2, for instance is permeable for Ca 2+ and is the only member of the TRPM family known to be expressed on human and murine neutrophils . TRPM2 may play an important role as a stress sensor, translating metabolic and oxidative signals into Ca 2+ flux . This channel is activated by ADP ribose (ADPR), cyclic ADPR (cADPR), adenosine monophosphate (AMP), nicotinic acid adenine dinucleotide phosphate (NAADP) and by hydrogen peroxide (H 2 O 2 ) .…”

Section: Other Ion Channels Involved In Ca2+ Signalling In Neutrophilsmentioning

confidence: 99%

“…54,56,63 TRPM2 may play an important role as a stress sensor, translating metabolic and oxidative signals into Ca 2+ flux. 64 This channel is activated by ADP ribose (ADPR), cyclic ADPR (cADPR), adenosine monophosphate (AMP), nicotinic acid adenine dinucleotide phosphate (NAADP) and by hydrogen peroxide (H 2 O 2 ). 64 Additionally, TRPM2 may be involved in Ca 2+ signalling downstream of formyl-peptide receptors (FPRs), but not downstream of chemokine receptors, as impaired Ca 2+ flux was shown in TRPM2 À/À mPMNs following fMLF, but not CXCL2 stimulation.…”

Section: Trp Channelsmentioning

confidence: 99%

“…64 This channel is activated by ADP ribose (ADPR), cyclic ADPR (cADPR), adenosine monophosphate (AMP), nicotinic acid adenine dinucleotide phosphate (NAADP) and by hydrogen peroxide (H 2 O 2 ). 64 Additionally, TRPM2 may be involved in Ca 2+ signalling downstream of formyl-peptide receptors (FPRs), but not downstream of chemokine receptors, as impaired Ca 2+ flux was shown in TRPM2 À/À mPMNs following fMLF, but not CXCL2 stimulation. 65 Further evidence for a specific role of TRPM2 in fMLFinduced signalling comes from the observation that in hPMNs, TRPM2 acts exclusively downstream of FPRs.…”

Section: Trp Channelsmentioning

confidence: 99%

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Calcium signalling and related ion channels in neutrophil recruitment and function

Immler

Simon

Sperandio

2018

Eur J Clin Investigation

101

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The recruitment of neutrophils to sites of inflammation, their battle against invading microorganisms through phagocytosis and the release of antimicrobial agents is a highly coordinated and tightly regulated process that involves the interplay of many different receptors, ion channels and signalling pathways. Changes in intracellular calcium levels, caused by cytosolic Ca store depletion and the influx of extracellular Ca via ion channels, play a critical role in synchronizing neutrophil activation and function. In this review, we provide an overview of how Ca signalling is initiated in neutrophils and how changes in intracellular Ca levels modulate neutrophil function.

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Section: Other Ion Channels Involved In Ca2+ Signalling In Neutrophilsmentioning

confidence: 99%

Section: Trp Channelsmentioning

confidence: 99%

Section: Trp Channelsmentioning

confidence: 99%

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Calcium signalling and related ion channels in neutrophil recruitment and function

Immler

Simon

Sperandio

2018

Eur J Clin Investigation

101

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“…Considering the ubiquitous expression of TRPM7, it is not surprising that the protein has a fundamental and non-redundant role in cellular physiology (1,35). It is involved in processes as diverse as proliferation, growth, migration, apoptosis, differentiation and exocytosis (36). Tissue-specific deletion of TRPM7 in thymocytes or macrophages, as well as inactivation of the kinase activity (Trpm7 R/R ) in mice highlights the importance of this unique signalling protein for an operating immune system that is still kept in check (24,26,37).…”

Section: Introductionmentioning

confidence: 99%

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

Nadolni¹,

Zierler²

2018

Preprint

Self Cite

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The enzyme-coupled transient receptor potential channel subfamily M member 7, TRPM7, has been associated with immunity and immune cell signalling. Here, we review the role of this remarkable signalling protein in lymphocyte proliferation, differentiation, activation and survival. We also discuss its role in mast cell, neutrophil and macrophage function and highlight the potential of TRPM7 to regulate immune system homeostasis. Further, we shed light on how the cellular signalling cascades involving TRPM7 channel and/or kinase activity culminate in pathologies as diverse as allergic hypersensitivity, arterial thrombosis, and graft versus host disease (GVHD), stressing the need for TRPM7 specific pharmacological modulators.

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“…Previous research has documented TRPM2, TRPM4 and TRPM5 channel expression on lymphocyte subsets [30] [31]. However, there is limited literature on TRPM3 expression on NK cells as only two previous investigations using flow cytometry have reported TRPM3 [29] [32].…”

Section: Introductionmentioning

confidence: 99%

Transient Receptor Potential Melastatin 3 and Intracellular Calcium in Natural Killer Cells in Multiple Sclerosis

Clarke¹,

Broadley²,

Nguyen³

et al. 2018

IJCM

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TRPM channels as potential therapeutic targets against pro-inflammatory diseases

Cited by 32 publications

References 150 publications

Calcium signalling and related ion channels in neutrophil recruitment and function

Calcium signalling and related ion channels in neutrophil recruitment and function

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

Transient Receptor Potential Melastatin 3 and Intracellular Calcium in Natural Killer Cells in Multiple Sclerosis

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