TRPC3 and TRPC6 Contribute to the Pathogenesis of Hypertension

Abstract

Recently studies found that TRPC3 and TRPC6 played an important role in cardiovascular disease. Hypertension, as a cardiovascular disease causing the highest morbidity and mortality, has close relationship with the expressions of TRPC3 and TRPC6. Unbalanced calcium homeostasis is the major factor of pathogenesis of hypertension. Changes of intracellular calcium concentration depend on calcium transmembrane transportation, intracellular calcium store releasing and other processes. TRPC3, TRPC6 molecules, as non-selective cation channels on the cell membranes, are involved in the processes. This review illustrated the functions of TRPC3 and TRPC6 on myocardial cells, smooth muscle cells and inflammatory cells in the development of hypertension, and the effects of drugs like sildenafil to provide a new way for the prevention and treatment of hypertension.

Ion channels and transporters in diabetic kidney disease

“…The Ang II-mediated activation of the TRPC6 channel leads to engorgement of the podocyte with calcium, which causes podocyte cell death and breakdown of the GFB. This inevitably leads to albuminuria which is a hallmark of DKD ( Fig 5) (Adebiyi, Soni, John, & Yang, 2014;Eckel et al, 2011;Evans, Lee, & Ragolia, 2009;Ilatovskaya, Levchenko, Lowing, et al, 2015;Ilatovskaya et al, 2014;Nijenhuis et al, 2011;Qin Zou, 2015;Reiser et al, 2005;Sonneveld et al, 2014;Zhang, Ding, Fan, & Liu, 2009). Our recent studies using a TRPC6 knockout on the Dahl SS rat background (SS Trpc6−/− ) indicate that TRPC6 channel inhibition may have at least partial renoprotective effects in the context of type 1 DN (Spires et al, 2018).…”