TRPC channels, an overarching Ca2+ paradigm in the developing heart

Qu, Yongxia; Boutjdir, Mohamed

doi:10.1093/cvr/cvr243

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…It should be noted that other studies indicated that TRPC channels can form a macromolecule complex with the NCX [44], Na + /K + pump [45], and SERCA pump [46]. Therefore, they might create a microenvironment facilitating the fine-tuning of Ca 2+ homeostasis and excitation-contraction coupling (reviewed elsewhere [47][48][49]). In fact, recent evidence confirmed that TRPC3 mediates Ca 2+ and Na + entry in proximity of NCX, elevating Ca 2+ levels and cardiac contractility [44].…”

Section: Trpc Channels In the Cardiovascular Systemmentioning

confidence: 99%

TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease

Falcón

Galeano-Otero

Martín-Bórnez

et al. 2020

Cells

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Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli. As other TRP channels, TRPC channels may form homo or heterotetrameric ion channels, and they can associate with other membrane receptors and ion channels to regulate intracellular calcium concentration. Dysfunctions of TRPC channels are involved in many types of cardiovascular diseases. Significant increase in the expression of different TRPC isoforms was observed in different animal models of heart infarcts and in vitro experimental models of ischemia and reperfusion. TRPC channel-mediated increase of the intracellular Ca2+ concentration seems to be required for the activation of the signaling pathway that plays minor roles in the healthy heart, but they are more relevant for cardiac responses to ischemia, such as the activation of different factors of transcription and cardiac hypertrophy, fibrosis, and angiogenesis. In this review, we highlight the current knowledge regarding TRPC implication in different cellular processes related to ischemia and reperfusion and to heart infarction.

show abstract

Section: Trpc Channels In the Cardiovascular Systemmentioning

confidence: 99%

TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease

Falcón

Galeano-Otero

Martín-Bórnez

et al. 2020

Cells

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show abstract

“…It should be noted that other studies indicated that TRPC channels can form macromolecule complex with NCX [34,35], Na+/K+ pump [36] and SERCA pump [37]. Thereby, they might create a microenvironment facilitating the fine-tuning of Ca 2+ homeostasis [5,38,39] and excitation-contraction coupling [40]. In fact, recent evidences confirmed that TRPC3 mediates Ca 2+ and Na + entry in proximity of NCX, elevating Ca 2+ levels and cardiac contractility [35].…”

Section: Trpc Channels In the Cardiovascular Systemmentioning

confidence: 97%

TRPC channels: Dysregulation and Ca<sup>2+</sup> Mishandling In Ischemic Heart Disease

Falcón

Galeano-Otero

Martín-Bórnez

et al. 2019

Preprint

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Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli. As other TRP, TRPC may form homo or heterotetrameric ion channel, and they can associate with other membrane receptors and ion channels to regulate intracellular calcium concentration. Dysfunctions of TRPC channels are involved in many types of cardiovascular diseases. Significant increase of the expression of different TRPC isoforms has been observed in different animal model of heart infarcts, and in vitro experimental model of ischemia and reperfusion. TRPC-mediated increase of the intracellular Ca2+ concentration seems required for the activation of signaling pathway that plays minor roles in the healthy heart, but they are more relevant for cardiac responses to ischemia, such as the activation of different factors of transcription and cardiac hypertrophy, fibrosis, and angiogenesis. In this review, we will highlight the current knowledge regarding TRPC implication in different cellular processes related to ischemia and reperfusion, and to heart infarction.

show abstract

TRPC channels, an overarching Ca2+ paradigm in the developing heart

Cited by 2 publications

References 18 publications

TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease

TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease

TRPC channels: Dysregulation and Ca<sup>2+</sup> Mishandling In Ischemic Heart Disease

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