2008
DOI: 10.1113/jphysiol.2008.158030
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TRPA1: irritant detector of the airways

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Cited by 24 publications
(12 citation statements)
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“…Reactive chemicals such as AITC do not cause pain behavior in TRPA1 knockout mice, confirming that their actions are mediated exclusively by TRPA1 Kwan et al, 2006). These studies resulted in the proposal that TRPA1 acts as a sensor for reactive chemicals in the body (Gerhold and Bautista, 2008). In agreement with this hypothesis, it was reported that the endogenous aldehyde 4-hydroxynonenal (4-HNE) causes pain and neurogenic inflammation through activation of TRPA1 (Trevisani et al, 2007).…”
Section: Introductionsupporting
confidence: 67%
“…Reactive chemicals such as AITC do not cause pain behavior in TRPA1 knockout mice, confirming that their actions are mediated exclusively by TRPA1 Kwan et al, 2006). These studies resulted in the proposal that TRPA1 acts as a sensor for reactive chemicals in the body (Gerhold and Bautista, 2008). In agreement with this hypothesis, it was reported that the endogenous aldehyde 4-hydroxynonenal (4-HNE) causes pain and neurogenic inflammation through activation of TRPA1 (Trevisani et al, 2007).…”
Section: Introductionsupporting
confidence: 67%
“…). One of the most commonly expressed subtypes of TRP channels in the airways is the TRP ankyrin (A) 1 channel, which has emerged as a major irritant detector . It has been shown that TRPA1 is activated in vitro by irritants such as acrolein, tear gas, vehicle exhaust , ozone , hydrogen peroxide, and hypochlorite .…”
Section: Pathophysiological Mechanisms Involved In Occupational Airwamentioning
confidence: 99%
“…Nasal nociceptive stimulation was performed by TRPA1 agonists allyl-isothiocyanate (AITC) and cinnamaldehyde which actually may represent a model for air-born irritants induced signalling [10] . The broad spectrum of irritants like acrolein, isocyanates, oxidizing substances and other pollutants activate the cation channel TRPA1 by covalent modification of the channel protein [11,12]. Activation of this channel leads to a sensation of airway irritation [13].…”
Section: Introductionmentioning
confidence: 99%