Trp207 regulation of voltage-dependent activation of human Hv1 proton channel

Voltage Sensors Embedded in G Protein-Coupled Receptors

“…They found that none of the reported mutations in the binding site affected the slope of the Q-V relation and are thus probably not part of the main voltage sensor. Some of these mutations had an effect on the V 1/2 of the Q-V curve, however, suggesting that these residues play some form of indirect role in the movement of the voltage sensor [24], similar to the complex role of residues outside the S4-based voltage sensor in determining the voltage dependence of voltage-gated channels [25,26]. An interesting observation from the aforementioned study was that a mutation in the M2R Asp69 2.50 residue eliminated the gating currents.…”