TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain

Artero-Morales, Maite; González-Rodríguez, Sara; Ferrer-Montiel, Antonio

doi:10.3389/fmolb.2018.00073

Cited by 37 publications

(33 citation statements)

References 189 publications

(248 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Findings from previous studies support the hypothesis of cortical excitability as a plausible mechanism underlying their pathology [60]. Further, there is corroboration from the scientific study of the nervous system that cortical spreading depression and an epileptic focus may exacerbate each other [61].…”

Section: Discussionsupporting

confidence: 55%

The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

2020

View full text Add to dashboard Cite

Background: Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and significantly impacts the quality of life. However, epidemiologic data from different studies showed different rates of prevalence. Therefore, we conducted this review to summarize the available epidemiologic evidence on the topic and formulate recommendations for future research and clinical practice. Methods: We followed the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. We systematically searched the literature using popular databases such as PubMed, EMBASE, Psych-INFO, and SCOPUS. We further scanned the reference lists of the eligible studies to supplement our electronic search. The Comprehensive Meta-Analysis software version 3.0 (CMA 3.0) was used to conduct a meta-analysis. Subgroup and sensitivity analysis were performed and Cochran's Q-and the I 2-test were used to assess the source of heterogeneity. The funnel plot and Egger's regression tests were used to assess potential publication bias. Results: A total of 17 studies conducted both in developed and developing countries including 5564 study participants were combined in this meta-analysis. The pooled estimated prevalence of headache among patients with epilepsy was 48.4%. The pooled estimated prevalence of Inter-Ictal headache (IIH) (42.2%) and Postictal headache (PIH) (43.1%) were higher when compared to tension-type headache (TTH) (26.2%), migraine with aura (26.0%) and migraine without aura (10.4%). The pooled prevalence of headache was 50.6% and 49.5% for developed and developing countries respectively. The pooled prevalence of headache among patients with epilepsy was considerably higher among females (63.0%) when compared to males (33.3%). Moreover, the pooled estimated prevalence of headache among patients with epilepsy was ranging from 46.0% to 52.2% in a leave-one-out sensitivity analysis. Conclusion: The pooled estimated prevalence of headache among patients with epilepsy was considerably high (48.4%). Screening and appropriate management of headaches among patients with epilepsy are warranted.

show abstract

Section: Discussionsupporting

confidence: 55%

The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

2020

View full text Add to dashboard Cite

show abstract

“…To our best knowledge there is no available data about sex differences in structure or function of airway afferent nerves nor the differences in expression of ion channels or other sensors/transducers relevant for cough reflex. Even in similar expression pattern between sexes, these channels, sensors and transducers can be modulated in a different way in the presence of sex hormones (Artero-Morales et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Female Guinea Pig Model for Cough Studies and Its Response to Most Common Tussive Substances

Sterusky¹,

Plevková²,

Grendár³

et al. 2020

Physiol Res

View full text Add to dashboard Cite

Laboratory research of cough reflex utilizes almost exclusively male guinea pigs – a practice that represents a significant obstacle in the successful translation of results into clinical practice. Chronic hypersensitivity cough syndrome affects mostly postmenopausal women and it represents significant decrease in patient’s quality of life. No cause for such exaggerated cough can be found, therefore this condition cannot be treated appropriately. One of the reasons leading to the lack of relevant data about mechanisms responsible for hypersensitivity of cough related pathways is nowadays widely discussed gender bias, which is present in nearly all branches of biomedical research. Since gender differences in cough reflex physiology do exist in humans, it would be reasonable to study cough-related phenomena on both sexes of laboratory animals. In this study, we focused on detailed characterization of cough response of female guinea pigs to aerosols of commonly used tussive agents (capsaicin, distilled water, allyl isothiocyanate, cinnamaldehyde, citric acid). In pooled data from multiple challenges we found no statistical difference in number of cough and cough latency between sexes. Based on our results we conclude that the utilization of female guinea pigs model does not lead to messy data and can be used in basic cough research.

show abstract

“…Unfortunately, pain studies aimed at other aspects than a sex or gender bias seldom report outcome variables according to sex or gender and only mention the proportion of males or females among study participants ( Supplementary Table 1). As a consequence, although the sexneutral neurophysiology of the pain pathway is well-described in several reviews (Basbaum et al, 2009;Zeilhofer et al, 2012;Peirs et al, 2015;Kendroud and Hanna, 2019) (Figure 2), little is known about sex differences in pain processing, except for modulation by sex-related hormones (Taleghany et al, 1999;Vincent and Tracey, 2008;Artero-Morales et al, 2018). These biological aspects are at least as important as the psychological aspect (Foo et al, 2017).…”

Section: Why Does Central Sensitization Occur?mentioning

confidence: 99%

Immune System Sex Differences May Bridge the Gap Between Sex and Gender in Fibromyalgia

2020

View full text Add to dashboard Cite

The fibromyalgia syndrome (FMS) is characterized by chronic widespread pain, sleep disturbances, fatigue, and cognitive alterations. A limited efficacy of targeted treatment and a high FMS prevalence (2-5% of the adult population) sums up to high morbidity. Although, altered nociception has been explained with the central sensitization hypothesis, which may occur after neuropathy, its molecular mechanism is not understood. The marked female predominance among FMS patients is often attributed to a psychosocial predisposition of the female gender, but here we will focus on sex differences in neurobiological processes, specifically those of the immune system, as various immunological biomarkers are altered in FMS. The activation of innate immune sensors is compatible with a neuropathy or virus-induced autoimmune diseases. Considering sex differences in the immune system and the clustering of FMS with autoimmune diseases, we hypothesize that the female predominance in FMS is due to a neuropathy-induced autoimmune pathophysiology. We invite the scientific community to verify the autoimmune hypothesis for FMS.

show abstract

TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain

Cited by 37 publications

References 189 publications

The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

Female Guinea Pig Model for Cough Studies and Its Response to Most Common Tussive Substances

Immune System Sex Differences May Bridge the Gap Between Sex and Gender in Fibromyalgia

Contact Info

Product

Resources

About