Troubles neurologiques sous Daptomycine en réanimation : effet indésirable ou mésusage ? Cas clinique

Durand, A.; Cayeux, S.; Adehossi, A.; Richecoeur, Jack; Schmit, B.

doi:10.1016/j.phclin.2020.08.005

Cited by 3 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The occurrence of neurological disorders is rare and their mechanism remains partially elucidated. Cases of encephalopathy and neuropsychiatric disorders have been reported in the literature [6][7][8]. To shed new light on the side effects of DAP, we report a case of confusion during DAP treatment, suggesting neurotoxicity.…”

Section: Introductionmentioning

confidence: 99%

A Case of Confusion in an Obese Patient Treated With Daptomycin: Neurotoxicity

Randrianarisoa,

Raulin,

Merlin

et al. 2024

Cureus

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

A Case of Confusion in an Obese Patient Treated With Daptomycin: Neurotoxicity

Randrianarisoa,

Raulin,

Merlin

et al. 2024

Cureus

View full text Add to dashboard Cite

“…Only a few antibiotics, such as daptomycin and linezolid, have been approved in recent years to combat the threat of drug resistance. VanX is one of five genes that, when activated in pathogenic VRE, cause the production of the cell wall to create precursors of peptidoglycan chains that end in D-alanyl-D-lactate (D-Ala-D-lactate) rather than the typical D-Ala-D-Ala residues [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Design, Synthesis, and Evaluation of Diaminopimelic Acid Derivatives as Potential dapF Inhibitors Preventing Lysine Biosynthesis for Antibacterial Activity

et al. 2022

View full text Add to dashboard Cite

We created thiazole and oxazole analogues of diaminopimelic acid (DAP) by replacing its carboxyl groups and substituting sulphur for the central carbon atom. Toxicity, ADME, molecular docking, and in vitro antimicrobial studies of the synthesized compounds were carried out. These compounds displayed significant antibacterial efficacy, with MICs of 70–80 µg/mL against all tested bacteria. Comparative values of the MIC, MBC, and ZOI of the synthesized compound were noticed when compared with ciprofloxacin. At 200 µg/mL, thio-DAP (1) had a ZOI of 22.67 ± 0.58, while ciprofloxacin had a ZOI of 23.67 ± 0.58. To synthesize thio-DAP (1) and oxa-DAP (2), l-cysteine was used as a precursor for the L-stereocenter (l-cysteine), which is recognized by the dapF enzyme’s active site and selectively binds to the ligand’s L-stereocenter. Docking studies of these compounds were carried out using the programme version 11.5 Schrodinger to reveal the hydrophobic and hydrophilic properties of these complexes. The docking scores of compounds one and two were −9.823 and −10.098 kcal/mol, respectively, as compared with LL-DAP (−9.426 kcal/mol.). This suggests that compounds one and two interact more precisely with dapF than LL-DAP. Chemicals one and two were synthesized via the SBDD (structure-based drug design) approach and these act as inhibitors of the dapF in the lysine pathway of bacterial cell wall synthesis.

show abstract

Daptomycin

2021

Reactions Weekly

View full text Add to dashboard Cite

Troubles neurologiques sous Daptomycine en réanimation : effet indésirable ou mésusage ? Cas clinique

Cited by 3 publications

References 13 publications

A Case of Confusion in an Obese Patient Treated With Daptomycin: Neurotoxicity

A Case of Confusion in an Obese Patient Treated With Daptomycin: Neurotoxicity

The Design, Synthesis, and Evaluation of Diaminopimelic Acid Derivatives as Potential dapF Inhibitors Preventing Lysine Biosynthesis for Antibacterial Activity

Daptomycin

Contact Info

Product

Resources

About