Troponin T elevation after permanent pacemaker implantation

Chen, Xueying; Yu, Ziqing; Bai, Jing; Hu, Shulan; Wang, Wei; Qin, Shengmei; Wang, Jingfeng; Sun, Zhe; Su, Yangang; Ge, Junbo

doi:10.1007/s10840-017-0247-5

Cited by 5 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the mild and transient elevation of cTNT in our study did not contribute to the poor prognosis, indicating that the increase in cTNT is mostly transient myocardial injury caused by occluder implantation, which does not affect cardiac ejection function and ventricular survival area. Our results were consistent with previous studies (28,29). Similarly, all patients in our study were followed up for 1 year, and the cTNT elevation had no relation to the complications of the procedure or cardiac outcomes.…”

Section: Discussionsupporting

confidence: 92%

Troponin T Elevation After Percutaneous Left Atrial Appendage Occlusion

Wang

Chen

et al. 2021

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

Background: Cardiac troponin T (cTNT) has been widely used in detecting cardiac damage. Elevated cTNT level has been reported to be associated with increased mortality in multiple cardiac conditions. It is not uncommon to observe an increased level of cTNT in patients after left atrial appendage occlusion (LAAO). The objective of the study is to study the incidence, significance, and factors associated with cTNT elevation after LAAO.Methods: We prospectively included patients who underwent LAAO from January 2019 to July 2020 in Fudan Zhongshan Hospital. Patients were divided into those with elevated cTNT after procedure and those with normal postprocedure cTNT. All individuals were followed up for 1 year. The primary outcome is major adverse cardiovascular events, which include myocardial infarction, heart failure, cardiac death, and stroke. The second outcome is periprocedure complication, including chest pain, tachycardia, cardiac tamponade, change of electrocardiograph, and atrial thrombus.Results: A total of 190 patients were enrolled. Of the patients, 85.3% had elevated cTNT after LAAO, while 14.7% of them did not. Exposure time, dosage of contrast, types of devices, shapes, and sizes of LAA could contribute to elevated postprocedure cTNT. We found that patients with a Watchman device were more likely to have elevated postprocedure cTNT than those with a Lambre device (89.2 vs. 76.7%, p = 0.029). LAAO shapes were associated with cTNT levels in patients with a Watchman device, while the diameter of the outer disc and LAA depth mattered for the Lambre device. There was no significant difference in the primary and second outcome between the two groups (p-value: 0.619, 0.674).Conclusion: LAAO was found to be commonly accompanied with cTNT elevation, which might not to be related to the complications and adverse cardiac outcomes within 1 year of follow-up. Moreover, eGFR at baseline, exposure time, dosage of contrast, types of LAAO device, and LAA morphology could contribute to cTNT elevation.

show abstract

Section: Discussionsupporting

confidence: 92%

Troponin T Elevation After Percutaneous Left Atrial Appendage Occlusion

Wang

Chen

et al. 2021

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…By retrieving related reports, we compared the troponin T change between RVP in a previous study 4 and LBBAP in this study. As shown in table 4, the myocardial damage of LBBAP was more serious than that of We explored the overall population to identify variables correlated with the increase of troponin T. Linear regression analysis was used to adjust for covariates that were found in the correlation analysis.…”

Section: Comparison With Other Types Of Ventricular Pacingmentioning

confidence: 99%

“…It is reported that transvenous insertion of the leads is followed by a sequence of cardiac histopathological changes, leading eventually to the formation of a fibrous connective tissue scar 3 . In the traditional way of pacing, most patients have a very slight troponin elevation after pacemaker implantation, leading to consider that it is not harmful to cardiac function and structure 4 .…”

Section: Introductionmentioning

confidence: 99%

Quantification of Acute Myocardial Damage Secondary to Implantation of Electrodes for the Left Bundle Branch Area Pacing

Chen

et al. 2021

RIC

View full text Add to dashboard Cite

Background: Different from the traditional right ventricular pacing, the left bundle branch area pacing (LBBAP) is accomplished with deeper lead implantation and more attempts. However, myocardial damage is unclear in LBBAP. Objective: The objective of the study was to observe the change of troponin T and explore possible factors associated with greater myocardial damage in LBBAP. Methods: Patients with an indication for pacemaker implantation underwent attempts for LBBAP by transventricular septal method. Levels of troponin T were determined before operation, 12 h and 1 week after the operation. Parameters of intraoperation and follow-up were recorded and analyzed. Results: In total, successful LBBAP was achieved in 126 patients. The levels of troponin T increased significantly at 12 h after the operation compared with those before operation (96.45 ± 11.07 [69.06] vs. 16.59 ± 1.84 [11.92] ng/L, p < 0.001), while there were no significant differences between pre-and post-operative levels at 1 week. Correlation and regression analysis showed that only the number of attempts was an independent factor related to the change of troponin T. During 1 year of follow-up, LBBAP was safe and feasible with few complications. Conclusions: Myocardial damage of LBBAP was clinically significant. The number of attempts was an independent factor related to the myocardial damage. (REV INVEST CLIN. [AHEAD OF PRINT]

show abstract

“…However, we could not identify any relation of increased biomarkers with procedure-related complications, lead displacement or rise in pacing threshold during a 1-month follow-up period. Consequently, this elevation in plasma cardiac biomarkers most likely represents the minimal myocardial damage that occurs during device implantation and seems not to be of clinical importance [13,14] .…”

Section: Discussionmentioning

confidence: 99%