Tropomyosins in Human Diseases: Ulcerative Colitis

Das, Kiron M.; Bajpai, Manisha

doi:10.1007/978-0-387-85766-4_13

Cited by 13 publications

(8 citation statements)

References 51 publications

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“…[52] reported that induction of TMs and stress fibers play an essential role in TGF-β-control of cell motility, and the loss of this TGF-β-response is a critical step in the acquisition of a metastatic phenotype by tumor cells. TMs are involved in pathogenesis of IBD, UC, and CD,[53–55] although the role in colitis-related colon oncogenesis is not known. Other proteins that were highly expressed in the tumor tissue were S100 calcium binding protein A9 and Peptidylprolylisomerase A.…”

Section: Discussionmentioning

confidence: 99%

Protein expression analysis of inflammation-related colon carcinogenesis

Yasui

Tanaka

2009

J Carcinog

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Background:Chronic inflammation is a risk factor for colorectal cancer (CRC) development. The aim of this study was to determine the differences in protein expression between CRC and the surrounding nontumorous colonic tissues in the mice that received azoxymethane (AOM) and dextran sodium sulfate (DSS) using a proteomic analysis.Materials and Methods:Male ICR mice were given a single intraperitoneal injection of AOM (10 mg/kg body weight), followed by 2% (w/v) DSS in their drinking water for seven days, starting one week after the AOM injection. Colonic adenocarcinoma developed after 20 weeks and a proteomics analysis based on two-dimensional gel electrophoresis and ultraflex TOF/TOF mass spectrometry was conducted in the cancerous and nontumorous tissue specimens.Results:The proteomic analysis revealed 21 differentially expressed proteins in the cancerous tissues in comparison to the nontumorous tissues. There were five markedly increased proteins (beta-tropomyosin, tropomyosin 1 alpha isoform b, S100 calcium binding protein A9, and an unknown protein) and 16 markedly decreased proteins (Car1 proteins, selenium-binding protein 1, HMG-CoA synthase, thioredoxin 1, 1 Cys peroxiredoxin protein 2, Fcgbp protein, Cytochrome c oxidase, subunit Va, ETHE1 protein, and 7 unknown proteins).Conclusions:There were 21 differentially expressed proteins in the cancerous tissues of the mice that received AOM and DSS. Their functions include metabolism, the antioxidant system, oxidative stress, mucin production, and inflammation. These findings may provide new insights into the mechanisms of inflammation-related colon carcinogenesis and the establishment of novel therapies and preventative strategies to treat carcinogenesis in the inflamed colon.

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Section: Discussionmentioning

confidence: 99%

Protein expression analysis of inflammation-related colon carcinogenesis

Yasui

Tanaka

2009

J Carcinog

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“…This leads to the recurring cycles of chronic inflammation that characterise CD. UC also has a clear autoimmune element, albeit different to that of CD 221, 222 . Recent work has found that isoforms of human tropomyosin (hTM 1–5) are capable of inducing auto-antibodies and T cell responses in UC 223 .…”

Section: Potential Mechanisms Of Organ Cross-talkmentioning

confidence: 99%

Pulmonary-intestinal cross-talk in mucosal inflammatory disease

2012

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Chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBD) are chronic inflammatory diseases of mucosal tissues that affect the respiratory and gastrointestinal tracts, respectively. They share many similarities in epidemiological and clinical characteristics as well as inflammatory pathologies. Importantly, both conditions are accompanied by systemic co-morbidities that are largely overlooked in both basic and clinical research. Therefore, consideration of these complications may maximise the efficacy of prevention and treatment approaches. Here, we examine both the intestinal involvement in COPD and the pulmonary manifestations of IBD. We also review the evidence for inflammatory organ cross-talk that may drive these associations, and discuss the current frontiers of research into these issues.

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“…This modulates the characteristic recurring cycles of chronic inflammation in Crohn's disease. Likewise, ulcerative colitis has an autoimmune component different to that of Crohn's disease [63,64] in that isoforms of human tropomyosin, capable of inducing autoantibodies and T-cell responses, have been observed in ulcerative colitis [65]. Similarly, autoimmunity could explain some elements of organ cross-talk in inflammatory disease.…”

Section: Respiratory Tractmentioning

confidence: 99%

Inflammatory bowel diseases, chronic liver diseases and the lung

Rodríguez-Roisin

Bartolome

Huchon³

et al. 2016

Eur Respir J

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This review is devoted to the distinct associations of inflammatory bowel diseases (IBD) and chronic liver disorders with chronic airway diseases, namely chronic obstructive pulmonary disease and bronchial asthma, and other chronic respiratory disorders in the adult population. While there is strong evidence for the association of chronic airway diseases with IBD, the data are much weaker for the interplay between lung and liver multimorbidities. The association of IBD, encompassing Crohn's disease and ulcerative colitis, with pulmonary disorders is underlined by their heterogeneous respiratory manifestations and impact on chronic airway diseases. The potential relationship between the two most prevalent liver-induced pulmonary vascular entities, i.e. portopulmonary hypertension and hepatopulmonary syndrome, and also between liver disease and other chronic respiratory diseases is also approached. Abnormal lung function tests in liver diseases are described and the role of increased serum bilirubin levels on chronic respiratory problems are considered. @ERSpublications Lung-gut cross-talk: the association of IBD with respiratory multimorbitidies, including COPD and bronchial asthma

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Tropomyosins in Human Diseases: Ulcerative Colitis

Cited by 13 publications

References 51 publications

Protein expression analysis of inflammation-related colon carcinogenesis

Protein expression analysis of inflammation-related colon carcinogenesis

Pulmonary-intestinal cross-talk in mucosal inflammatory disease

Inflammatory bowel diseases, chronic liver diseases and the lung

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