Tropical spastic paraparesis in colombia

Zaninovic, Vladimir; Arango, César; Biojo, Robin; Mora, Carlos A.; Rodgers‐Johnson, Pamela; Concha, Mauricio; Corral, Raul; Barreto, Pablo; Borrero, Isabella; Garruto, Ralph M.; Gibbs, Clarence J.; Gajdusek, D. Carleton

doi:10.1002/ana.410230730

Cited by 52 publications

(14 citation statements)

References 19 publications

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“…It is worthy to note the similarity in the numbers of anti-HTLV-I positive and negative patients with PSP in most of the regions. In contrast to previous reports (9,10,(12)(13)(14), our cases were mostly Caucasian/Indian, with a few patients of pure Indian ancestry (Huilliche or Mapuche). The pre valence of antibodies against HTLV-I in family members of the seropositive patients is clearly higher (18.9%) than in the general population (0.73% in blood donors) (15).…”

Section: Epidemiological Findingscontrasting

confidence: 97%

Progressive Spastic Paraparesis Associated with Human T-Cell Leukemia Virus Type I(HTLV-I).

et al. 1992

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Patients with progressive spastic paraparesis (PSP), commonly middle-aged women, are distributed throughout the country of Chile. During the three years from 1987 to 1990, we collected 83 cases of PSP from among 225 patients with various neurological diseases. The clinical picture was of a bilateral pyramidal syndrome, with sensory deficits in only 15.5% of the cases, and a slow illness progression in the majority of them. In patients with PSP, antibody to human T-cell leukemia virus type I (HTLV-I) was analyzed by enzyme linked immunosorbent assay (ELISA) and confirmed by western blot analysis. Forty-five (54.2%) patients were anti HTLV-I antibody positive in cerebrospinal fluid (CSF) and peripheral blood. Among them, 2 patients had leukemia/lymphoma and one had Sjogren syndrome. In the laboratory study of seropositive PSP, mononuclear pleocytosis was found in 35.7% ; there was an abnormal increase of the IgG index in 66.6% and an increase in CD2 in blood and CSF, and CD4 in blood. A delayed latency of somatosensory evoked potentials was observed in 90.9%. The neuropsycho logical study revealed a WAIS with a mean verbal IQ of 80.7 and a mean performance IQ of 84.8. The most impaired items were digit symbol and digit span. Seven subjects (18.9%) with anti-HTLV-I antibody were found among 37 relatives from 19 anti-HTLV-I positive cases of PSP.

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Section: Epidemiological Findingscontrasting

confidence: 97%

Progressive Spastic Paraparesis Associated with Human T-Cell Leukemia Virus Type I(HTLV-I).

et al. 1992

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“…If this concept is correct TSP should begin to appear in UK-bom subjects, provided viral transmission occurs in this temperate area, but it may take decades to become apparent given the inefficiency of acquisition. Host factors may also be important in determining whether a patient of Afro-Caribbean origin develops MS or a white European presents with TSP but data presented here, and those of Dean, [1][2][3][4][5][6] suggest that, as far as MS is concerned, environmental factors predominate over ethnic ones.…”

Section: Discussionmentioning

confidence: 94%

Multiple sclerosis, tropical spastic paraparesis and HTLV-1 infection in Afro-Caribbean patients in the United Kingdom.

Rudge

Amini

Cruickshank

1991

Journal of Neurology, Neurosurgery & Psychiatry

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Forty four consecutive patients of AfroCaribbean origin resident in the United Kingdom (UK) were studied, based on a provisional diagnosis of myelopathy of unknown cause, tropical spastic paraparesis (TSP) or multiple sclerosis (MS). Of 30 patients with progressive paraparesis 27 had serum antibodies to HTLV-1 and were classified as having TSP. Fourteen patients fulfilled the criteria for MS and none of 12 tested had HTLV-1 antibodies. All the TSP patients and nine of those with MS were born in the West Indies. Five of the West Indianborn MS patients had migrated to the UK after adolescence but the duration of residence in the UK before symptoms of MS developed was similar to those born in the UK (average 18 years). The features that differentiated MS from TSP patients, apart from HTLV-1 status, included clinical evidence of cranial nerve involvement, more extensive abnormalities on the brain and cervical cord MRI and asymmetry of the VEP latency increase, all of which were more frequent in the MS group. Of the three patients without a diagnosis one, born in the UK, had marked abnormalities on MRI of the brain indistinguishable from those seen in MS.

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“…El HTLV-I fue detectado en Colombia en 1981 por Zaninovic, et al, en una serie de pacientes provenientes de algunas poblaciones de la costa Pacífica que padecían de paraparesia espástica (8). El mismo grupo documentó sistemáticamente los reportes de caso y la prevalencia de la infección en otras regiones y grupos poblacionales del país, especialmente comunidades indígenas (9,10).…”

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Prevalencia de la infección con el virus linfotrópico de células T humanas de tipo 1 y 2 en donantes de sangre en Colombia, 2001-2014: implicaciones sobre la seguridad de la transfusión

Bermúdez-Forero¹,

Berrío-Pérez²,

Herrera-Hernández³

et al. 2016

biomedica

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conceptual y apoyo en el análisis de los datos Todos los autores participaron en la revisión crítica del documento y en la escritura del manuscrito. Materiales y métodos. Se hizo un análisis descriptivo y retrospectivo de la información enviada por la Red de Bancos de Sangre al Instituto Nacional de Salud sobre tamización, unidades reactivas y positividad para el HTLV 1 y 2 y sobre la estimación de riesgo de infección por la transfusión. Prevalencia de la infección con el virus linfotrópico de célulasResultados. Entre 2001 y 2014 se hizo en Colombia la tamización para la detección de anticuerpos de HTLV 1 y 2 de 60,2 % de la sangre captada, con una tasa acumulada de unidades reactivas de 0,3 %. Dicha tasa fue 20 veces superior en el departamento de Chocó (6,28 %), pese a que allí no se capta sangre desde el 2004. En el 2014, la tamización llegó a 94,9 %, con una positividad de 14,7 %. Con estos datos se pudo estimar que se transfundieron 406 unidades de glóbulos rojos potencialmente infecciosos, lo cual entrañaría una transmisión eficaz del virus a estos individuos. Pese a que no se le considera un departamento endémico, en Antioquia se registró la mayor proporción de pruebas positivas, con 215 unidades (53 %). Conclusiones. Los resultados obtenidos sugieren que la infección por HTLV 1 y 2 se distribuye en varias zonas del país que no eran catalogadas como endémicas. Se ratificó la importancia de la tamización universal de las unidades de sangre captadas, para minimizar el riesgo de infección con este agente por la vía de la transfusión.Palabras clave: virus 1 linfotrópico T humano, transfusión sanguínea, bancos de sangre, donantes de sangre, prevalencia, Colombia.

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Tropical spastic paraparesis in colombia

Cited by 52 publications

References 19 publications

Progressive Spastic Paraparesis Associated with Human T-Cell Leukemia Virus Type I(HTLV-I).

Progressive Spastic Paraparesis Associated with Human T-Cell Leukemia Virus Type I(HTLV-I).

Multiple sclerosis, tropical spastic paraparesis and HTLV-1 infection in Afro-Caribbean patients in the United Kingdom.

Prevalencia de la infección con el virus linfotrópico de células T humanas de tipo 1 y 2 en donantes de sangre en Colombia, 2001-2014: implicaciones sobre la seguridad de la transfusión

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