Tropical pulmonary eosinophilia misdiagnosed as miliary tuberculosis: A case report and literature review

Ray, Sayantan; Kundu, Supratip; Goswami, Manas; Maitra, Somnath

doi:10.1016/j.parint.2011.11.006

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…Mild hypoxemia can also be present in acutely ill patients [ 1 ]. Bronchoalveolar lavage fluid analysis indicates an intense eosinophilic response in the lungs [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy

Datta¹,

Chhotray²,

Jena³

et al. 2023

Cureus

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Tropical pulmonary eosinophilia (TPE) is a specific pulmonary manifestation of lymphatic filariasis. There is overwhelming infiltration of eosinophils in the lung parenchyma in response to microfilaria. The characteristic features include paroxysmal respiratory symptoms, strikingly high blood eosinophil count, elevated level of immunoglobulin (Ig) E along with high titer of anti-filarial antibody. Treatment with diethylcarbamazine (DEC) has an excellent favorable response. However, recovery may often be incomplete.We present a case of a 36-year-old man with TPE who had complete symptomatic improvement after a three-week course of DEC, but only a partial response in radiological and pulmonary function abnormalities.

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“…Mild hypoxemia can also be present in acutely ill patients [ 1 ]. Bronchoalveolar lavage fluid analysis indicates an intense eosinophilic response in the lungs [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy

Datta¹,

Chhotray²,

Jena³

et al. 2023

Cureus

View full text Add to dashboard Cite

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“…Increased eosinophil count (> 3,000/mcl) and IgE levels (> 1,000 U/mL) due to type 1 hypersensitivity is common (1). Radiography of chest sometime shows interstitial shadows, miliary mottling and mediastinal lymphadenopathy (2).…”

Section: Discussionmentioning

confidence: 99%

“…A large number of Indian population has latent TB and therefore mere positivity of mantoux test is never taken as indicative of active TB (3). There are few reports, where TPE was misdiagnosed as TB (2). The non-necrotic hilar lymph nodes and the raised ACE levels raised the suspicion of sarcoidosis in the first patient but ACE levels have been shown to have insufficient specificity for sarcoidosis (4).…”

Section: Discussionmentioning

confidence: 99%

First things first: Importance of eosinophil count in diagnosing occult parasites

Gupta

Ray

Ghosh

et al. 2018

DD&T

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Tropical pulmonary eosinophilia (TPE) is a rare allergic manifestation to the filarial nematode. A 38-year old male and a 15-year old female presented with cough and breathlessness. Their complete blood count showed eosinophilia. This finding was overshadowed by the radiological findings suggestive of tuberculosis. The diagnosis of TPE was confirmed by filarial antigen detection test and both the patients were successfully treated with diethylcarbamazine. TPE presents with cough and breathlessness and can be often confused with tuberculosis, especially in endemic settings. An important clue in differentiating the two entities is the presence of eosinophilia in the former.

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“…Therefore, long-term systemic corticosteroid therapy should be performed in combination with more targeted treatment approaches. For instance, parasitic EP is typically treated with anthelminthics; the effects of additional corticosteroid treatment could be beneficial (Boland et al, 2011;Ray et al, 2012). In this case, oral albendazole (0.4 g) was administered once for anti-parasitic treatment; oral methylprednisolone (40 mg) was given once daily as anti-inflammation therapy.…”

Section: A B Discussionmentioning

confidence: 99%

Case Report Muscle pain, fever, cough, and progressive dyspnea in a woman with eosinophilic pneumonia

Xu¹,

Fan²,

Wang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The diagnosis of eosinophilic pneumonia (EP) is rare and challenging. This condition is frequently misdiagnosed as pulmonary tuberculosis, lymphoma, schistosomiasis, Wegener's granuloma, severe acute respiratory syndrome, or severe communityacquired pneumonia. Herein, we report a case in which computed tomography (CT)-guided percutaneous lung biopsy was used to diagnose EP without alveolar eosinophilia or peripheral eosinophilia. A roundworm identified in the patient's stool confirmed the precise diagnosis to be parasitic EP. This is, to our knowledge, the first reported case of EP confirmed by CT-guided percutaneous lung biopsy. CT-guided percutaneous lung biopsy may represent a new tool for the diagnosis of EP in patients without typical alveolar eosinophilia or peripheral eosinophilia.

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Tropical pulmonary eosinophilia misdiagnosed as miliary tuberculosis: A case report and literature review

Cited by 6 publications

References 13 publications

A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy

A Case of Tropical Pulmonary Eosinophilia With Incomplete Response to Diethylcarbamazine Therapy

First things first: Importance of eosinophil count in diagnosing occult parasites

Case Report Muscle pain, fever, cough, and progressive dyspnea in a woman with eosinophilic pneumonia

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