Summary The genus Striga contains some of the most noxious parasitic plants, which have a devastating impact on cereal production in Africa; of most importance are Striga hermonthica and Striga asiatica. Complete resistance to infection by Striga species does not exist in cultivated cereals. Of great interest is the possibility that wild relatives of cereals may provide a genetic basis for resistance or tolerance to infection and may be of enormous value for the development of resistant crops. A wild relative of cultivated sorghum, Sorghum arundinaceum, demonstrated tolerance to infection by S. asiatica, with little impact of S. asiatica on host growth or grain production compared with the detrimental impact of the parasite on cultivated sorghum. Infection by S.hermonthica, however, had a significant influence on host performance for both wild and cultivated sorghum. Differences in host:parasite responses may be explained by the timing of parasite attachment and differences in host specificity for these two Striga species.