Tropic role of enteroglucagon in pancreatic adaptation to subtotal enterectomy

Watanapa, P.; Williamson, R. C. N.; Beardshall, K; Calam, J.

doi:10.1002/bjs.1800780807

Cited by 11 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been reported that enteroglucagon plays a major role in the adaptive response of the residual ileum after a small bowel resection [5,6]. Furthermore, Watanapa et al reported that enteroglucagon may have a pancreatotrophic, in addition to enterotrophic, activity [16]. We also reported that enteroglucagon plays an important role in the adaptive pancreatic hyperplasia observed after a 90% proximal small bowel resection [17,18].…”

Section: Discussionsupporting

confidence: 62%

Plasma Glicentin Concentration in Patients with Crohn's Disease.

Sasaki

Myojo

Tsujikawa

et al. 1998

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

Enteroglucagon has been reported to have trophic effects on the intestinal mucosa, and is associated with proliferation and repair after various injuries of the small intestine. Glicentin is an active enteroglucagon, and is present in the largest amount in the intestine. We established a method for quantifying human plasma levels of glicentin, and measured these levels in patients with Crohn's disease. Twenty-three patients with Crohn's disease (14 males and 9 females) and 8 healthy adults were enrolled in this study. A sandwich ELISA method was used to quantify immunoreactive glicentin in plasma sampled from subjects fasting in the early morning and after the oral administration of 75 g glucose (Trelan G(R)®). The plasma glicentin levels in fasting subjects were significantly higher in patients with active-stage Crohn's disease, and were similar between the remission-stage Crohn's disease and normal controls. These levels after glucose administration were significantly higher in patients with active-stage Crohn's disease than in those with the disease in remission or in healthy controls. However, the pattern of the changes in the plasma glicentin levels after the glucose administration was similar among the three groups. These data suggest that plasma glicentin levels might reflect the pathological conditions and activity in Crohn's disease.

show abstract

Section: Discussionsupporting

confidence: 62%

Plasma Glicentin Concentration in Patients with Crohn's Disease.

Sasaki

Myojo

Tsujikawa

et al. 1998

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

show abstract

“…Both 1 week and 1 month after 90% proximal small bowel resection, 5-72% increments in pancreatic mass correlated with 83-150% increments in enteroglucagon levels, while neurotensin levels were unchanged (Watanapa et al, 1991a). CCK proved to be another candidate for the role of pancreatotropin.…”

Section: Other Specific Dietary Constituentsmentioning

confidence: 90%

Experimental pancreatic hyperplasia and neoplasia: effects of dietary and surgical manipulation

Watanapa

Williamson²

1993

Br J Cancer

Self Cite

View full text Add to dashboard Cite

Summary Several studies carried out during the past two decades have investigated the effect of dietary and surgical manipulation on pancreatic growth and carcinogenesis. Diets high in trypsin inhibitor stimulate pancreatic growth and increase the formation of preneoplastic lesions and carcinomas in the rat pancreas. Cholecystokinin (CCK) is the key intermediary in this response, since both natural and synthetic trypsin inhibitors increase circulating levels of the hormone and CCK antagonists largely prevent these changes. Fatty acids enhance pancreatic carcinogenesis in both rats and hamsters, whereas protein appears to have a protective role in the rat, but to increase tumour yields in the hamster. Several surgical operations affect the pancreas. Pancreatobiliary diversion and partial gastrectomy stimulate pancreatic growth and enhance carcinogenesis, probably by means of increased CCK release. Complete duodenogastric reflux has similar effects on the pancreas but the gut peptide involved is gastrin. Although massive small bowel resection increases pancreatic growth, the marked reduction in caloric absorption probably explains its failure to enhance carcinogenesis. CCK and enteroglucagon might work in concert to modulate the tropic response of the pancreas to small bowel resection. In the pancreas, as in the large intestine, hyperplasia appears to precede and predispose to neoplasia.

show abstract

“…but lowers pancreatic polypeptide [40]. After ileocecal resection, pancreatic hyperplasia has been shown without changes in basal levels of plasma CCK [41], whereas after subtotal enterectomy increased basal CCK and enteroglucagon levels accompanied the pancreatic growth [42,43]. Thus, gastrointestinal surgery evokes different hormonal effects, that probably result in the different pancreatic changes seen.…”

Section: Discussionmentioning

confidence: 99%

Changes in Rat Pancreas following Gastric Surgery Are Not Correlated with Basal Levels of Serum Gastrin or Plasma Cholecystokinin

et al. 1996

View full text Add to dashboard Cite

Forty male rats weighing 150 g were operated on with gastrectomy with esophagoduodenostomy, antrectomy, fundectomy, or bilateral truncal vagotomy with pyloroplasty. Unoperated rats served as controls. The rats were freely fed, but not pair-fed, until sacrifice by exsanguination after 8 weeks. The pancreas was excised, weighed, and analyzed for contents of water, protein, amylase, and DNA. Basal levels of serum gastrin and plasma cholecystokinin (CCK) were only measured at sacrifice. Eight weeks after the operation, gastrectomized and antrectomized rats had lowered serum gastrin concentrations, while fundectomized and vagotomized rats had increased concentrations as compared with control rats. The concentration of plasma CCK was increased in fundectomized rats only. The operated rats had a lower body weight than the controls. The pancreatic wet weight relative to the body weight was increased after gastrectomy and vagotomy, but decreased after antrectomy. The protein content was lowered after antrectomy, but the content relative to the body weight was increased after gastrectomy and vagotomy. Antrectomy decreased the DNA content, while the other operative procedures were without similar effect. The pancreas was atrophic after antrectomy with a decreased DNA content, whereas gastrectomy evoked a slight hypertrophy, although both procedures induced hypogastrinemia. Fundectomy did not evoke any changes in the pancreas, whereas vagotomy increased the amylase content. Neither the concentration of gastrin in serum nor the concentration of CCK in plasma correlated with any of the changes in the pancreatic parameters studied. Thus, gastric surgery in the rat influenced the pancreatic integrity, but the observed changes were unrelated to basal levels of serum gastrin and plasma CCK.

show abstract

Tropic role of enteroglucagon in pancreatic adaptation to subtotal enterectomy

Cited by 11 publications

References 27 publications

Plasma Glicentin Concentration in Patients with Crohn's Disease.

Plasma Glicentin Concentration in Patients with Crohn's Disease.

Experimental pancreatic hyperplasia and neoplasia: effects of dietary and surgical manipulation

Changes in Rat Pancreas following Gastric Surgery Are Not Correlated with Basal Levels of Serum Gastrin or Plasma Cholecystokinin

Contact Info

Product

Resources

About