Trophoblastic invasion in vitro and in vivo: similarities and differences

Helige, Christine; Ahammer, Helmut; Hammer, Astrid; Huppertz, Berthold; Frank, Hans-Georg; Dohr, Gottfried

doi:10.1093/humrep/den198

Cited by 36 publications

(21 citation statements)

References 35 publications

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“…The decidua is composed of many cell types, with the immune cells and the decidual cells in majority. Of these, the immune cells have been considered as prime regulators of trophoblast invasion and the role of NK cells has been comprehensively detailed. Herein, we will define the role of paracrine signals specifically from the decidual cells in regulation of trophoblast invasion.…”

Section: Decidual Control Of Trophoblast Invasionmentioning

confidence: 99%

“…Co‐culture systems of decidual fragments with trophoblast cells have demonstrated that the EVTs actively invade and get embedded into the decidual bed, the spiral arteries and also the glandular epithelium . Biochemically, the EVTs achieve this active invasive potential by producing high amounts of matrix metalloproteinases (MMPs) to degrade the extracellular matrix .…”

Section: Decidual Control Of Trophoblast Invasionmentioning

confidence: 99%

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Decidual Control of Trophoblast Invasion

Sharma

Godbole

Modi

2016

American J Rep Immunol

223

184

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At the time of implantation, the trophoblast cells of the embryo adhere and then invade into the maternal endometrium and eventually establish placentation. The endometrium at the same time undergoes decidualization, which is essential for successful pregnancy. While the NK cells of the decidua have been implicated to play a key role in trophoblast invasion, few evidence are now available to demonstrate a pro-invasive property of decidual stromal cells. Secretions from decidualized endometrial stromal cells promote invasion of primary trophoblasts and model cell lines by activating proteases and altering expression of adhesion-related molecules. The decidual secretions contain high amounts of pro-invasive factors that include IL-1b, IL-5, IL-6, IL-7, IL-8, IL-9, IL-13, IL-15, Eotaxin CCL11, IP-10 and RANTES, and anti-invasive factors IL-10, IL-12 and VEGF. It appears that these decidual factors promote invasion by regulating the protease pathways and integrin expression utilizing the STAT pathways in the trophoblast cells. At the same time the decidua also seem to secrete some anti-invasive factors that are antagonist to the matrix metalloproteinases and/or are activators of tissue inhibitors of metalloproteinases. This might be essential to neutralize the effects of the invasionpromoting factors and restrain overinvasion. It is tempting to propose that during the course of pregnancy, the decidua must balance the production of these pro and anti-invasive molecules and such harmonizing production would allow a timely and regulated invasion.

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Section: Decidual Control Of Trophoblast Invasionmentioning

confidence: 99%

Section: Decidual Control Of Trophoblast Invasionmentioning

confidence: 99%

Decidual Control of Trophoblast Invasion

Sharma

Godbole

Modi

2016

American J Rep Immunol

223

184

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“…The increased numbers of macrophages, with decreased numbers of M2 macrophages may thus already be present before the onset pre-eclampsia and therefore suggest a role for macrophages in defective trophoblast invasion and spiral artery remodeling. Recent in vitro data showed that macrophages migrate toward invading trophoblast (126), while other groups have shown that activated macrophages in vitro are able to inhibit trophoblast invasion and spiral artery remodeling (127, 128). In vivo , data have shown that there is a reciprocal presence of trophoblast cells and macrophages in the spiral arteries of both healthy and pre-eclamptic women (121).…”

Section: Decidual Macrophagesmentioning

confidence: 99%

Monocytes and Macrophages in Pregnancy and Pre-Eclampsia

2014

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Preeclampsia is an important complication in pregnancy, characterized by hypertension and proteinuria in the second half of pregnancy. Generalized activation of the inflammatory response is thought to play a role in the pathogenesis of pre-eclampsia. Monocytes may play a central role in this inflammatory response. Monocytes are short lived cells that mature in the circulation and invade into tissues upon an inflammatory stimulus and develop into macrophages. Macrophages are abundantly present in the endometrium and play a role in implantation and placentation in normal pregnancy. In pre-eclampsia, these macrophages appear to be present in larger numbers and are also activated. In the present review, we focused on the role of monocytes and macrophages in the pathophysiology of pre-eclampsia.

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“…Several in vitro co-culture systems have established that the EVTs actively invade through the decidua, the spiral arteries, and the glandular epithelium (5,6). The EVTs achieve this invasive potential by producing high amounts of matrix metalloproteinases (MMPs) (1,7,8).…”

mentioning

confidence: 99%