Gene Cell Tissue

2016

DOI: 10.17795/gct-38516

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Trophoblast Giant Cells, the Prime Suspects of Deficient Placentation Associated With Pregnancy Complications

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Cited by 6 publications

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“…36 In our study, reducing the size and volume of the placenta in the SGA-IUGR group could be associated with decreased blood vessels and oxygenation in the chorionic villi and insufficient development of the placenta, which is probably due to a decrease in the number of EVTs and their reduced invasion. 10,12,19,37,38 In summary, infants of the IUGR group may be injured by hypoxemia because of low placental weight and decreased exchange surface. However, investigations of volumetric parameters on EVTs are limited.…”

Section: Discussionmentioning

confidence: 99%

Reduced volumetric parameters of the placenta and extravillous trophoblastic cells in complicated pregnancies may lead to intrauterine growth restriction and small for gestational age birth

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Mahmoudzadeh‐Sagheb

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et al. 2022

J of Obstet and Gynaecol

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Aim We undertook this study to determine quantitative changes of the placenta, focusing on extravillous trophoblastic cells (EVTs) in pregnancies with intrauterine growth restriction (IUGR) and small for gestational age (SGA) compared to the control group. Methods Placentas from pregnancies complicated with SGA‐IUGR (n = 10) and control group (n = 10) were obtained after cesarean surgery and evaluated using stereological assays after routine tissue processing and Masson's trichrome staining. Mann–Whitney U‐test was employed, and the level of statistical significance was set at p <0.05. Results Our results showed that the volumetric parameters, including the total volume and volume density of chorionic villi, intervillous spaces, blood vessels in chorionic villi, and syncytiotrophoblast, decreased significantly in the SGA‐IUGR group compared to control placentas (p <0.05). Also, total volume, number of EVTs, volume, the diameter of cytoplasm, and diameter of the nucleus in these cells were significantly lower in the SGA‐IUGR group (p <0.05). In addition, the nucleus to cytoplasm ratio of EVTs was also higher in the SGA‐IUGR group (p <0.05). Conclusions There are several significant histological and stereological differences in the placenta, particularly its EVTs from the SGA‐IUGR group compared to the control group. It seems that histological changes in the placental tissues could be helpful for the retrospective explanations of pregnancy complications.

“…36 In our study, reducing the size and volume of the placenta in the SGA-IUGR group could be associated with decreased blood vessels and oxygenation in the chorionic villi and insufficient development of the placenta, which is probably due to a decrease in the number of EVTs and their reduced invasion. 10,12,19,37,38 In summary, infants of the IUGR group may be injured by hypoxemia because of low placental weight and decreased exchange surface. However, investigations of volumetric parameters on EVTs are limited.…”

Section: Discussionmentioning

confidence: 99%

Reduced volumetric parameters of the placenta and extravillous trophoblastic cells in complicated pregnancies may lead to intrauterine growth restriction and small for gestational age birth

¹

,

²

,

Mahmoudzadeh‐Sagheb

³

et al. 2022

J of Obstet and Gynaecol

Self Cite

View full text Add to dashboard Cite

Aim We undertook this study to determine quantitative changes of the placenta, focusing on extravillous trophoblastic cells (EVTs) in pregnancies with intrauterine growth restriction (IUGR) and small for gestational age (SGA) compared to the control group. Methods Placentas from pregnancies complicated with SGA‐IUGR (n = 10) and control group (n = 10) were obtained after cesarean surgery and evaluated using stereological assays after routine tissue processing and Masson's trichrome staining. Mann–Whitney U‐test was employed, and the level of statistical significance was set at p <0.05. Results Our results showed that the volumetric parameters, including the total volume and volume density of chorionic villi, intervillous spaces, blood vessels in chorionic villi, and syncytiotrophoblast, decreased significantly in the SGA‐IUGR group compared to control placentas (p <0.05). Also, total volume, number of EVTs, volume, the diameter of cytoplasm, and diameter of the nucleus in these cells were significantly lower in the SGA‐IUGR group (p <0.05). In addition, the nucleus to cytoplasm ratio of EVTs was also higher in the SGA‐IUGR group (p <0.05). Conclusions There are several significant histological and stereological differences in the placenta, particularly its EVTs from the SGA‐IUGR group compared to the control group. It seems that histological changes in the placental tissues could be helpful for the retrospective explanations of pregnancy complications.

Elevated immunoexpression of interferon-gamma in placenta tissue samples from pregnancies complicated with preeclampsia compared to the placenta previa

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Mahmoudzadeh‐Sagheb

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et al. 2020

Pregnancy Hypertension

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Quantitative changes of extravillous trophoblast cells in heavy smoker mothers compared with healthy controls

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Mahmoudzadeh‐Sagheb

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2018

Reprod. Fertil. Dev.

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Maternal smoking during pregnancy can induce structural and functional changes in the placenta. Placentas from heavy smoker (>20 cigarettes per day) mothers and non-smoker healthy controls (n=10 in each group) were enrolled in the present case-control study. Sample selection and sectioning were performed by systematic uniform random sampling (SURS). Selected sections were stained using Masson's trichrome to estimate quantitative parameters of placental extravillous trophoblast cells (EVTs) and the number of EVTs. Differences between groups were evaluated using the Mann-Whitney U-test, with significance set at P<0.05. There was a significant difference in placental weight and the total volume of the placenta between the heavy smoker and control groups (P<0.05). The total volume of EVTs, nucleus diameter, cytoplasm diameter, the volume of the nucleus and cytoplasm and the nucleus to cytoplasm ratio of EVTs were significantly greater in the heavy smoker compared with control group (P<0.05 for all). In placentas from heavy smokers, the total number of EVTs per unit volume of placental bed were significantly greater than in the control group (P<0.05 for both). In conclusion, the findings suggest that maternal smoking could affect fetal health by changing the quantitative parameters of the placenta, and likely the invasive properties of EVTs.

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