Trophic microRNA: Precursor and mature microRNA ingestion downregulates the target transcripts and hampers larval development inPlutella xylostella
Rutwik Bardapurkar,
Sagar Pandit
Abstract:MicroRNAs (miRNAs) are post-transcriptional gene regulators. In the miRNA pathway’s cytoplasmic part, the miRNA is processed from a hairpin-structured precursor (pre-miRNA) to a double-stranded (ds) mature RNA and ultimately to a single-stranded mature miRNA. In insects, ingesting these two ds forms can regulate the target gene expression; this inspired the trophic miRNA’s use as a functional genomics and pest management tool. However, systematic studies enabling comparisons of pre- and mature forms, dosages, … Show more
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