Trophic effects of continuous infusion of [Leu15]-gastrin-17 in the rat

Ryberg, B.; Axelson, Jan; Håkanson, R.; Sundler, F.; Mattsson, Hillevi

doi:10.1016/0016-5085(90)91287-g

Cited by 142 publications

(50 citation statements)

References 13 publications

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“…Because gastrin has a powerful trophic effect on oxyntic mucosal cells in vivo (15)(16)(17)(18)(19)(20)23) as well as in vitro (33,34), it is probable that the elevated levels of serum gastrin contribute to the hypertrophy in H2R-deficient mice. However, the study using a gastric adenocarcinoma cell line has revealed that H2R antagonists, roxatidine and ranitidine, enhanced parietal cell proliferation without any increase in the amount of mRNA expression of either TGF-α or EGFR, indicating that the H2R-mediated signal may be involved in the gastric cell proliferation (21).…”

Section: Discussionmentioning

confidence: 99%

“…The trophic effect of gastrin for oxyntic mucosa has also been studied. Longterm administration of gastrin, histamine H2R antagonist, or proton pump inhibitor (PPI) increased plasma gastrin concentration and lead to hypertrophy of oxyntic mucosa, caused by increased numbers of mucosal cells (14)(15)(16). In addition, recent studies using genetically engineered mice deficient in gastrin or CCK-BR have demonstrated the importance of gastrin signal(s) as a trophic effect on oxyntic mucosa (17)(18)(19)(20).…”

mentioning

confidence: 99%

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Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor–deficient mice

Kobayashi¹,

Tonai²,

Ishihara³

et al. 2000

J. Clin. Invest.

149

100

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor–deficient mice

Kobayashi¹,

Tonai²,

Ishihara³

et al. 2000

J. Clin. Invest.

149

100

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“…That is, omeprazole inhibits gastric acid secretion completely and for a prolonged period, and this achlorhydria induces the release of gastrin into the blood. This hypergastrinemia produces hyperplasia of ECL cells though the proliferous action of gastrin (10,11,20).…”

Section: Discussionmentioning

confidence: 99%

Antisecretory and Antiulcer Effects of YM020, a New H+,K+-ATPase Inhibitor, in Rats and Dogs

Yuki¹,

Kamato²,

Nishida³

et al. 1995

Japanese Journal of Pharmacology

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We examined the effects of YM020 (3-cyanomethyl-2-methyl-8-[(3-methyl-2-butenyl)oxy]-imidazo[1,2-a]pyridine), a novel H+,K+-ATPase inhibitor, on gastric acid secretion and experimental gastroduodenal lesions in rats and dogs. Intraduodenal, subcutaneous and oral YM020 inhibited basal gastric acid secretion in pylorus-ligated rats with ED50 values of 9.1, 9.1 and 9.5 mg/kg, respectively. Oral pretreatment with YM020 5 hr before ligation still suppressed acid secretion, with a potency a little less than that of omeprazole. In anesthetized dogs, intravenous YM020 inhibited histamine-, methacholine-and pentagastrin-induced gastric acid secretion with ED50 values of 0.05, 0.01 and 0.08 mg/kg, respectively. In Heidenhain pouch dogs, although oral YM020 (3 mg/kg) inhibited histamine-induced acid secretion, acid output returned to control levels faster than in dogs treated with omeprazole. Oral YM020 inhibited the formation of water-immersion restraint stress-, indomethacin-, absolute ethanol-, 0.7 N hydrochloric acid-and cysteamine-induced gastric or duodenal lesions with ED50 values of 2.9, 4.3, 2.0, 11.7 and 8.4 mg/kg, respectively. Moreover, subcutaneous YM020 also suppressed the formation of ethanol-and HCl-induced gastric lesions. These results suggest that YM020 has an antisecretory effect almost the same as or 2 to 3 times weaker than those of omeprazole and that its duration is not as long as that of omeprazole in rats and dogs. Furthermore, YM020 possesses a cytoprotective effect and the mechanism of YM020 may be different to that of omeprazole.

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“…Exogenous gastrin stimulates DNA synthesis in the fundic gastric mucosa and an increase in pancreatic weight (Hansen et al, 1976;Solomon et al, 1987;Ryberg et al, 1990). Surgical antrectomy in the rat leads to reduced DNA synthesis in the pancreas, oxyntic glands, duodenal and colonic mucosa that can be reversed with pentagastrin treatment (Dembinski & Johnson, 1979).…”

Section: Gastrinmentioning

confidence: 99%

Neuropeptide growth factors and cancer

Woll

1991

Br J Cancer

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Trophic effects of continuous infusion of [Leu15]-gastrin-17 in the rat

Cited by 142 publications

References 13 publications

Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor–deficient mice

Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor–deficient mice

Antisecretory and Antiulcer Effects of YM020, a New H+,K+-ATPase Inhibitor, in Rats and Dogs

Neuropeptide growth factors and cancer

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