Trophic Effect of Truncal Vagotomy on the Rat Pancreas

Koop, H.; Schwarting, H; Trautmann, Michael E.; Börger, H. W.; Lankisch, P.G.; Arnold, R.; Creutzfeldt, W.

doi:10.1159/000199295

Cited by 14 publications

(6 citation statements)

References 16 publications

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“…Vagotomy has previously been shown to increase the pancreatic weight [32][33][34], whereas this has not been found by others [3,22], Vagotomy did not influence the plasma concentration of CCK in the present study, but the results suggest a trophic influence of vagotomy on the pancreas. This seems to depend on other factors than a decreased body weight or hypergastrinemia.…”

Section: Discussioncontrasting

confidence: 92%

Changes in Rat Pancreas following Gastric Surgery Are Not Correlated with Basal Levels of Serum Gastrin or Plasma Cholecystokinin

et al. 1996

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Forty male rats weighing 150 g were operated on with gastrectomy with esophagoduodenostomy, antrectomy, fundectomy, or bilateral truncal vagotomy with pyloroplasty. Unoperated rats served as controls. The rats were freely fed, but not pair-fed, until sacrifice by exsanguination after 8 weeks. The pancreas was excised, weighed, and analyzed for contents of water, protein, amylase, and DNA. Basal levels of serum gastrin and plasma cholecystokinin (CCK) were only measured at sacrifice. Eight weeks after the operation, gastrectomized and antrectomized rats had lowered serum gastrin concentrations, while fundectomized and vagotomized rats had increased concentrations as compared with control rats. The concentration of plasma CCK was increased in fundectomized rats only. The operated rats had a lower body weight than the controls. The pancreatic wet weight relative to the body weight was increased after gastrectomy and vagotomy, but decreased after antrectomy. The protein content was lowered after antrectomy, but the content relative to the body weight was increased after gastrectomy and vagotomy. Antrectomy decreased the DNA content, while the other operative procedures were without similar effect. The pancreas was atrophic after antrectomy with a decreased DNA content, whereas gastrectomy evoked a slight hypertrophy, although both procedures induced hypogastrinemia. Fundectomy did not evoke any changes in the pancreas, whereas vagotomy increased the amylase content. Neither the concentration of gastrin in serum nor the concentration of CCK in plasma correlated with any of the changes in the pancreatic parameters studied. Thus, gastric surgery in the rat influenced the pancreatic integrity, but the observed changes were unrelated to basal levels of serum gastrin and plasma CCK.

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Section: Discussioncontrasting

confidence: 92%

Changes in Rat Pancreas following Gastric Surgery Are Not Correlated with Basal Levels of Serum Gastrin or Plasma Cholecystokinin

et al. 1996

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“…Truncal vagotomy has been suggested to exert a trophic effect on the exocrine pancreas [16], while studies by Büchler et al [4] indicated that pancreatic growth after truncal vagotomy depended rather on hyperplasia than on hypertrophy. Other authors have failed to show any effect on total or relative pancreatic weight or DNA content after truncal vagotomy in the rat [5].…”

Section: Discussionmentioning

confidence: 99%

The effect of selective sympathetic denervation on pancreatic exocrine secretion

et al. 1997

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The purpose of this study was to investigate the influence of selective sympathetic denervation of the rat pancreas on exocrine secretion and to study whether the observed effects were due to pancreatic trophism. Sprague-Dawley rats were divided into two groups. One group underwent selective sympathetic denervation by skeletonizing the superior and inferior pancreaticoduodenal and splenic arteries. The other group underwent simple laparotomy and served as controls. One week after the operation a catheter was introduced into the bile-pancreatic duct and pancreatic juice was collected at 30-min intervals for 4 h. The output of bicarbonate, total protein, amylase, trypsin, chymotrypsin, lipase, colipase and carboxyesterlipase were determined. Following denervation secretion of pancreatic enzymes was significantly enhanced compared with sham-operated animals. We did not find any signs of pancreatic trophism 1 week after denervation.

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“…However, in case of such pancreatic insufficiency a certain degree of exocrine aci nar dystrophy might generally be expected [ 1 ]. On the other hand, truncal vagotomy has been shown to induce a direct trophic effect on the pancreas, resulting in a significant weight gain of all parts of the pancreas [39], This hypertrophy of the pancreas is probably related to the important hypergastrinemia that follows most forms of vagotomy, but may also be connected to the important gas tric stasis that was observed after truncal vagotomy and pyloroplasty [18]. Whereas in the study of Koop et al [ 18] this pancreatic hypertrophy did not result in a rise of amy lase or lipase production from the exocrine acini, it certainly did not lead to a dimin ished pancreatic enzyme secretion.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Function after Seromyotomy of the Canine Stomach

Hee¹,

Verhulst²,

Schil³

1988

Eur Surg Res

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Anterior gastric seromyotomy combined with posterior truncal vagotomy has been proposed as an acid-reducing operation for patients with duodenal ulcer. Section of the posterior vagal trunk could, however, be held responsible for reduced pancreatic function, seen in patients after bilateral truncal vagotomy. In this study the pancreatic function after anterior gastric seromyotomy and posterior truncal vagotomy has been evaluated in a series of canine experiments by means of a direct hormone stimulation test. No reduction of the basal or stimulated exocrine pancreatic secretion was noted after this type of vagotomy.

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Trophic Effect of Truncal Vagotomy on the Rat Pancreas

Cited by 14 publications

References 16 publications

Changes in Rat Pancreas following Gastric Surgery Are Not Correlated with Basal Levels of Serum Gastrin or Plasma Cholecystokinin

Changes in Rat Pancreas following Gastric Surgery Are Not Correlated with Basal Levels of Serum Gastrin or Plasma Cholecystokinin

The effect of selective sympathetic denervation on pancreatic exocrine secretion

Pancreatic Function after Seromyotomy of the Canine Stomach

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