Trophic Actions of Bone Marrow-Derived Mesenchymal Stromal Cells for Muscle Repair/Regeneration

Sassoli, Chiara; Zecchi‐Orlandini, Sandra; Formigli, Lucia

doi:10.3390/cells1040832

Cited by 25 publications

(26 citation statements)

References 144 publications

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“…[38, 39] Interestingly, this rate was found to increase when the two cell types were transplanted together likely due to trophic effects of MSCs resulting in paracrine interactions that promote satellite cell differentiation. [40, 41] Finally, pluripotent stem cells also represent a potential progenitor cell source when differentiated into myogenic progenitor cells (MPCs). [42, 43] …”

Section: Skeletal Muscle Tissue Engineering Approachesmentioning

confidence: 99%

Anisotropic Materials for Skeletal‐Muscle‐Tissue Engineering

2016

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Repair of damaged skeletal muscle tissue is limited by the regenerative capacity of native tissue. Current clinical approaches are not optimal for treatment of large volumetric skeletal muscle loss. As an alternative, tissue engineering represents a promising approach for the functional restoration of damaged muscle tissue. A typical tissue engineering process involves the design and fabrication of a scaffold that closely mimics the native skeletal muscle extracellular matrix allowing for organization of cells into a physiologically relevant, 3D architecture. In particular, anisotropic materials, which mimic the morphology of the native skeletal muscle ECM, can be fabricated using various biocompatible materialsto guide cell alignment, elongation, proliferation and differentiation into myotubes. In this article, we first provide an overview of fundamental concepts associated with muscle tissue engineering and the current status of the muscle tissue engineering approaches. We then review recent advances in development of anisotropic scaffolds with micro- or nano-scale features and examine how scaffold topographical, mechanical, and biochemical cues correlate to observed cellular function and phenotype development. Finally, we highlight some recent developments in both the design and utility of anisotropic materials in skeletal muscle tissue engineering along with their potential impact on future research and clinical application.

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Section: Skeletal Muscle Tissue Engineering Approachesmentioning

confidence: 99%

Anisotropic Materials for Skeletal‐Muscle‐Tissue Engineering

2016

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“…These cells promote the development of lymphocytes from bone marrow cells, 5 and consequently, amphirionin-4 (1) may have utility in enhancing immune response to disease and bone regeneration. 4a,6 Structurally, amphirionin-4 comprises an allsyn-tetrahydrofuranol core with both a remote allylic alcohol at C9 and skipped tetraene motif on the heptadecyl side chain.…”

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confidence: 99%

Total Synthesis of Amphirionin-4

et al. 2015

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“…The detection of transplanted MSCs at the site of injury does not necessarily imply that these donor cells differentiate and fuse with existing myofibers, but rather that their recruitment to, and presence at, the defect site considerably increases the chances of muscle repair [70]. There is a general consensus among researchers that MSCs exert their beneficial therapeutic effects via paracrine secretion of soluble factors [71,72]. This effectively implies that as long as the transplanted MSCs maintain their viability in vivo, they would continue to secrete vital factors and contribute to muscle repair.…”

Section: Scaffold-free Cell Therapy: Promises and Drawbacksmentioning

confidence: 98%