Trophic action of epidermal growth factor on the pancreas and gastroduodenal mucosa in rats.

Abstract

SUMMARY1. Epidermal growth factor (EGF) infused subcutaneously in a dose of 10 ,g/kg . h but not 1 jug/kg . h inhibited spontaneous gastric acid and pepsin secretion, whereas when given intragastrically in a dose of 10 jug/kg . h it failed to affect this secretion.2. EGF injected intraperitoneally at 8 h intervals for 24 h significantly stimulated DNA synthesis in the gastroduodenal mucosa and the pancreas, whereas when administered intragastrically it stimulated DNA synthesis only in the gastroduodenal mucosa but not in the pancreas.3. Chronic parenteral administration of EGF significantly increased the DNA and RNA contents of the gastroduodenal mucosa and the pancreas.4. This study demonstrates that parenteral EGF is a potent inhibitor of gastric secretion and trophic agent for the gastroduodenal mucosa and pancreas, and that the gastric inhibitory and trophic effects of EGF are the results of two separate mechanisms.

Epidermal Growth Factor in Neonatal Mouse Urine: Maturative Effect of Thyroxine

“…suppresses the immune response (39, inhibits gastric acid secretion (3), stimulates DNA synthesis (6,12,27,38) accelerates wound healing (3 1, 40),and causes angiogenesis in the avascular corneal stroma (1 5). In accordance with these effects, EGF and its receptors are present in various tissues in the fetus and adult (1, 4, 1 1, 14,30,33).…”

Use of in vivo Whole-Body Autoradiography to Identify the Distribution of Epidermal Growth Factor Binding Sites under Normal Conditions in the Mouse Digestive System.

“…However, although parenteral administration of EGF stimulates intestinal growth and maturation in suckling rodents (3,63,70) and intraluminal administration of EGF stimulates a mucosal proliferative response in the small intestine of the adult rat (82), the effects of parenterally administered EGF on the intestine of adult rodents were equivocal (1,14,24,75). Our investigation showed that the intestines from duodenum to rectum have specific EGF binding at short intervals (3 and 6 min) after 125I-EGF injection, although the levels of binding were low.…”

Transgenic expression of epidermal growth factor and keratinocyte growth factor in beta-cells results in substantial morphological changes

“…In addition, while investigating the remarkable proliferative and differentiation patterns of the Ins-IFN-mouse, EGF and EGF-R were found to be upregulated (Arnush et al 1996). Indeed, EGF has previously been shown to modulate pancreatic growth (Dembinski et al 1982, Logsdon 1986, 1987, Marti et al 1989, Verme & Hootman 1990, Mangino et al 1992. For example, systemic administration of EGF resulted in the induction of pancreatic duct proliferation in pigs (Vinter-Jensen et al 1997).…”

“…However, EGF and transforming growth factor -1 (TGF -1) were able to induce ductal and endocrine cell development respectively (Sanvito et al 1994). While the ability of EGF to stimulate epithelial cell and fibroblast proliferation is well documented, it has also demonstrated mitogenic properties for pancreatic growth (Dembinski et al 1982, Logsdon 1986, 1987, Marti et al 1989, Verme & Hootman 1990, Mangino et al 1992. In addition, evidence exists linking the overexpression of EGF and its receptor to both chronic pancreatitis and malignant pancreatic growth (Barton et al 1991, Korc et al 1992, Yamanaka et al 1993, Friess et al 1996.…”