Tropane alkaloids from Erythroxylum emarginatum

Nishiyama, Yumi; Moriyasu, Masataka; Ichimaru, Momoyo; Sonoda, Maki; Iwasa, Kinuko; Kato, Atsushi; Juma, Francis D.; Mathenge, Simon G.; Mutiso, Patrick B. Chalo

doi:10.1007/s11418-006-0018-6

Cited by 12 publications

(8 citation statements)

References 7 publications

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“…highlighted the presence of terpenoids, 5,6 flavonoids, 5,7 and alkaloids. 8 Some of the isolated compounds from this genus exhibit pharmacological activities, such as antifungal, 6,7 antioxidant, 3,8 antileishmanial, 9 cytotoxic, 5,10 anti-inflammatory, 5,11 antinociceptive, 5,11 acaricidal, 12 and insecticidal activities. 6,13 The relevant literature indicates 160 known species of this genus, 14 and, approximately 20% (~30 species) have had previous chemical/pharmacological studies carried out, which reinforces the importance of new studies regarding the species of Xylopia.…”

Section: Introductionmentioning

confidence: 99%

DIVERSITY OF THE DITERPENES IN THE LEAVES OF Xylopia laevigata (Annonaceae) AND THEIR CYTOTOXICITIES

et al. 2020

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The phytochemical investigation of the hexane extract which was obtained from the leaves of Xylopia laevigata (Annonaceae) produced six terpenes. Among these, five diterpenes named abieta-7,13-dien-3-one, ent-7β-acetoxy-16β-hydroxy-kaurane, 4-epi-cupressic acid, powerol, and labdorffianic acid B, and one oxygenated sesquiterpene, spathulenol. This is the first time these isolated diterpenes from X. laevigata have been described. The different structures belong to the abietane, kaurane, and labdane diterpenoids, and are indicative of the chemical diversity found in X. laevigata. Moreover, the diterpene ent-7β-acetoxy-16β-hydroxykaurane is reported herein for the first time as a natural product, and 4-epi-cupressic acid, powerol, and labdorffianic acid B are reported for the first time in the Annonaceae family. The structures of the isolated compounds were established by extensive analyses using 1D and 2D NMR spectroscopy in combination with MS. The cytotoxic activities of compounds abieta-7,13-dien-3-one, spathulenol, 4-epi-cupressic acid, and powerol were evaluated against tumor and non-tumor cell lines, in which spathulenol was found to be the most active, mainly against K562 with an IC 50 value of 17.20 µmol L-1 .

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Section: Introductionmentioning

confidence: 99%

DIVERSITY OF THE DITERPENES IN THE LEAVES OF Xylopia laevigata (Annonaceae) AND THEIR CYTOTOXICITIES

et al. 2020

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“…The flowers are in small axillary clusters, white, fragrant. The fruit is a drupe ellipsoid, fleshy and red [10] . The decoction of leaves is used to treat asthma, arthritis and influenza and kidney problems and reproduction [4] .…”

Section: Introductionmentioning

confidence: 99%

Determination of Polyphenols and Anti-Inflammatory Activity of Aqueous and Ethanolic Extracts of Erythroxylum Emarginatum (Erythroxylaceae)

Victor¹,

Timothee²,

Gisele³

et al. 2016

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Our work was part of the search for new active molecules in the inflammatory process to relieve pain more effectively. Erythroxylum emarginatum is a plant distributed in tropical regions of South America, Africa, and Madagascar. The phytochemical screening has shown that the bark of stems contained more full of polyphenols than the leaves. Erythroxylum emarginatum is known for its anti-inflammatory properties, its use in the treatment of bronchial affections and especially during asthma. The comparative study of Erythroxylum emarginatum bark of stems aqueous and ethanolic extracts with diclofenac on induced inflammation of rat paw by carrageenan revealed anti-inflammatory properties of both extracts. In effect at doses of 200 mg/kg of body weight, both extracts have anti-inflammatory properties comparable to those of diclofenac dosed at 25mg/kg body weight. These results would justify the use of Erythroxylum emarginatum bark of stems by people to prevent inflammatory processes in arthritis and asthma.

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“…The leaves of Olokuto, a wild Erythroxylum species known as Erythroxylum dekindtii, are used to reduce fever in Angola. In addition, the roots and leaves of E. emarginatum are used for pain relief, to increase alertness and also as an aphrodisiac (Nishiyama et al, 2007). It is also very common for tropane alkaloid-producing plants to be used as a panacea.…”

Section: Introductionmentioning

confidence: 99%