Trop2 Guarantees Cardioprotective Effects of Cortical Bone-Derived Stem Cells on Myocardial Ischemia/Reperfusion Injury

Li, Tianyu; Su, Yue; Yu, Xiongli; Mouniir, Durgahee S.A.; Masau, Jackson Ferdinand; Wei, Xiang; Yang, Jian-Ye

doi:10.1177/0963689718786882

Cited by 17 publications

(13 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the damaged adult stomach, Trop2 is re-expressed and might be associated with regeneration processes [ 20 ]. The pro-regenerative potential of Trop2-positive cells was also described in the in vivo model of murine endometrial regeneration [ 24 ], and Trop2-positive cortical bone-derived stem cells hold superior pro-regenerative effect after myocardial infarction in mice [ 25 ].…”

Section: Trop2 In Healthy Tissue and Developmentmentioning

confidence: 99%

Trop2: Jack of All Trades, Master of None

Lenárt

Šmarda

et al. 2020

Cancers

View full text Add to dashboard Cite

Trophoblast cell surface antigen 2 (Trop2) is a widely expressed glycoprotein and an epithelial cell adhesion molecule (EpCAM) family member. Although initially identified as a transmembrane protein, other subcellular localizations and processed forms were described. Its congenital mutations cause a gelatinous drop-like corneal dystrophy, a disease characterized by loss of barrier function in corneal epithelial cells. Trop2 is considered a stem cell marker and its expression associates with regenerative capacity in various tissues. Trop2 overexpression was described in tumors of different origins; however, functional studies revealed both oncogenic and tumor suppressor roles. Nevertheless, therapeutic potential of Trop2 was recognized and clinical studies with drug–antibody conjugates have been initiated in various cancer types. One of these agents, sacituzumab govitecan, has been recently granted an accelerated approval for therapy of metastatic triple-negative breast cancer. In this article, we review the current knowledge about the yet controversial function of Trop2 in homeostasis and pathology.

show abstract

Section: Trop2 In Healthy Tissue and Developmentmentioning

confidence: 99%

Trop2: Jack of All Trades, Master of None

Lenárt

Šmarda

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…This phenomenon has also been observed in gallbladder cancer [ 16 ]. Among the various biochemical mechanisms involved in tumorigenesis, the role of β-catenin has been studied extensively [ 8 , 17 – 19 ]. This has shed light on the biological functions of TROP2 and its use as a prognostic biomarker for OSCC.…”

Section: Introductionmentioning

confidence: 99%

Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation

Zhang

Gao

et al. 2020

BMC Cancer

View full text Add to dashboard Cite

Background: Trophoblast cell surface antigen 2 (TROP2) is overexpressed in many squamous cell carcinomas and promotes tumor development and invasion. The association between TROP2 expression and occurrence and development of oral squamous cell carcinoma (OSCC) remains to be understood. Methods: We investigated the role of TROP2 in OSCC patients using a combination of biophysical approaches. A total of 108 OSCC patient specimens with varying degrees of differentiation were subjected to hematoxylin and eosin staining, immunohistochemistry, Kaplan-Meier survival curve analysis, and atomic force microscopy to analyze TROP2 expression, morphology, and mechanical properties of OSCC tissues. Results: TROP2 was overexpressed in 34% of poorly differentiated OSCC samples. High levels of TROP2 were associated with 10.2% survival rate lower than 45.4% and patient age (odds ratio [OR] = 0.437, P = 0.039, 95% confidence interval [CI, 0.198-0.966]), tumor size (OR = 13.148, P = 0.000, 95% CI [5.060-34.168]), and TNM stage (OR = 0.141, P = 0.000, 95% CI [0.082-0.244]). Average surface roughness of low, medium, and highly differentiated OSCC tissues were 448.9 ± 54.8, 792.7 ± 83.6, and 993.0 ± 104.3 nm, respectively. The Pearson coefficient revealed a negative association between tumor stiffness and TROP2 expression (r = − 0.84, P < 0.01). Conclusion: Overexpression of TROP2 negatively associated with patient survival, degree of tumor differentiation, and tissue mechanics. Taken together, our findings demonstrated that TROP2 may be an indicator of OSCC differentiation leading to the altered mechanical properties of OSCC tissues.

show abstract

“…This phenomenon has also been observed in gallbladder cancer [16]. Among the various biochemical mechanisms involved in tumorigenesis, the role of β-catenin has been studied extensively [17][18][19][20]. This has shed light on the biological functions of TROP2 and its use as a prognostic biomarker for OSCC.…”

Section: Introductionmentioning

confidence: 78%

Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation

Zhang

Gao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Trophoblast cell surface antigen 2 (TROP2) is overexpressed in many squamous cell carcinomas and promotes tumor development and invasion. The association between TROP2 expression and occurrence and development of oral squamous cell carcinoma (OSCC) remains to be understood.Methods We investigated the role of TROP2 in OSCC patients using a combination of biophysical approaches. A total of 108 OSCC patient specimens with varying degrees of differentiation were subjected to hematoxylin and eosin staining, immunohistochemistry, Kaplan-Meier survival curve analysis, and atomic force microscopy to analyze TROP2 expression, morphology, and mechanical properties of OSCC tissues.Results TROP2 was overexpressed in 34% of poorly differentiated OSCC samples. High levels of TROP2 were associated with 10.2% survival rate lower than 45.4% and patient age (odds ratio [OR]=0.437, P=0.039, 95% confidence interval [CI, 0.198–0.966]), tumor size (OR=13.148, P=0.000, 95% CI [5.060–34.168]), and TNM stage (OR=0.141, P=0.000, 95% CI [0.082–0.244]). Average surface roughness of low, medium, and highly differentiated OSCC tissues were 448.9±54.8, 792.7±83.6, and 993.0±104.3 nm, respectively. The Pearson coefficient revealed a negative association between tumor stiffness and TROP2 expression (r=-0.84, P<0.01).Conclusion Overexpression of TROP2 negatively associated with patient survival, degree of tumor differentiation, and tissue mechanics. Taken together, our findings demonstrated that TROP2 may be an indicator of OSCC differentiation leading to the altered mechanical properties of OSCC tissues.

show abstract

Trop2 Guarantees Cardioprotective Effects of Cortical Bone-Derived Stem Cells on Myocardial Ischemia/Reperfusion Injury

Cited by 17 publications

References 49 publications

Trop2: Jack of All Trades, Master of None

Trop2: Jack of All Trades, Master of None

Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation

Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation

Contact Info

Product

Resources

About