‘Trojan-Horse’ stress-granule formation mediated by manganese oxide nanoparticles

Illarionova, N. B.; Morozova, Ksenia N.; Petrovskii, Dmitry V; Sharapova, M. B.; Romashchenko, A. V.; Troitskii, S. Yu.; Kiseleva, Elena; Moshkin, Yuri M.; Мошкин, М. П.

doi:10.1080/17435390.2020.1856433

Cited by 9 publications

(4 citation statements)

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“…According to the second hypothesized mode of action, when Doxorubicin enters the target cell's nucleus, it intercalates with the host DNA and targets TOP2A (167). TOP2A is in charge of separating entangled DNA, as well as temporarily generating and eventually repairing doublestrand DNAs (double-strand breaks [DSB]) (72). Doxorubicin slows the repair process by interfering with the function of TOP2A, resulting in the formation of a significant number of DSBs (168).…”

Section: Doxorubicinmentioning

confidence: 99%

Stress Granules in the Anti-Cancer Medications Mechanism of Action: A Systematic Scoping Review

et al. 2021

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Stress granule (SG) formation is a well-known cellular mechanism for minimizing stress-related damage and increasing cell survival. In addition to playing a critical role in the stress response, SGs have emerged as critical mediators in human health. It seems logical that SGs play a key role in cancer cell formation, development, and metastasis. Recent studies have shown that many SG components contribute to the anti-cancer medications’ responses through tumor-associated signaling pathways and other mechanisms. SG proteins are known for their involvement in the translation process, control of mRNA stability, and capacity to function in both the cytoplasm and nucleus. The current systematic review aimed to include all research on the impact of SGs on the mechanism of action of anti-cancer medications and was conducted using a six-stage methodological framework and the PRISMA guideline. Prior to October 2021, a systematic search of seven databases for eligible articles was performed. Following the review of the publications, the collected data were subjected to quantitative and qualitative analysis. Notably, Bortezomib, Sorafenib, Oxaliplatin, 5-fluorouracil, Cisplatin, and Doxorubicin accounted for the majority of the medications examined in the studies. Overall, this systematic scoping review attempts to demonstrate and give a complete overview of the function of SGs in the mechanism of action of anti-cancer medications by evaluating all research.

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Section: Doxorubicinmentioning

confidence: 99%

Stress Granules in the Anti-Cancer Medications Mechanism of Action: A Systematic Scoping Review

et al. 2021

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“…resulted in 100% death of brain tumors [ 13 ]. Another study showed that Mn 3 O 4 NPs was able to diminish the cellular respiration rate and also cause the apoptosis of glioblastoma cells (U87MG) by formation of stress-granules (SGs) with the ‘Trojan-horse’ mechanism [ 14 ]. In 2021, Shaik et al [ 15 ] reported that Mn 3 O 4 NPs showed significant antibacterial, antifungal, and anticancer properties.…”

Section: Introductionmentioning

confidence: 99%

Plant mediated biosynthesis of Mn3O4 nanostructures and their biomedical applications

Binjawhar,

Al-Enazi,

Alsamhary

et al. 2024

Heliyon

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BGRS/SB-2022 681 The role of manganese oxide nanoparticles in the formation of stress granules in the mouse olfactory system

2022

The Thirteenth International Multiconference

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Motivation and Aim: In recent years, air pollution has increased significantly, and humans, like other terrestrial animals, are constantly exposed to solid aerosols, which may contain various xenobiotics, including nanoparticles (NPs) that can enter the brain from the nasal cavity [1]. Moreover, it was shown that the addition of nanoparticles to the cellular environment induces the formation of stress granules (SG), which are the cellular response to stress [2]. However, whether nanoparticles cause the formation of SG in brain structures is unknown. The aim of this study was to investigate the ability of intranasally administered Mn3O4-NPs to induce SG formation in neurons of the mouse olfactory system. Methods and Algorithms: The work was performed on mice of SPF-status strain C57Bl/6 at the age of 8 weeks. The accumulation of NPs in the olfactory bulbs was assessed using T1-weighted images obtained on a BioSpec 17/16USR ultrahigh-field magnetic resonance tomograph (Bruker, Germany) with a magnetic field strength of 11.7 T. The amount of SG was determined on paraffin sections stained with a mixture of antibodies anti-eIF3η+anti-G3BP1. The intracellular localization of nanoparticles was studied using transmission electron microscopy (TEM). Paramagnetic Mn3O4-NPs were used as nanoparticles.Results: Using T1-weighted MRI, we were able to demonstrate that the accumulation of Mn3O4-NPs in the main olfactory bulb (MOB) of the mouse reaches a maximum 24 hours after their intranasal application. To estimate the role of manganese ions in the formation of the observed MRI signal, we determined the concentration of Mn in the MOB tissue before and after dialysis in mice that were injected with either Mn3O4-NPs or MnCl2 into the nasal cavity 24 hours before the isolation of MOB. As the analysis showed, in animals that were injected with Mn3O4-NPs, as a result of dialysis, there is practically no decrease in the concentration of manganese in the tissue. Whereas in mice injected with MnCl2, dialysis effectively reduces Mn concentrations in the MOB homogenate. This suggests that one day after the intranasal application of Mn3O4-NPs, manganese in the MOB is mainly in an insoluble form. Using TEM, we demonstrated that nanoparticles can be transported along the axons of olfactory neurons both intraand extra-vesicularly, which indicates the possibility of contact between Mn3O4-NPs and the contents of the neuron cytoplasm. Finally, using immunohistochemistry, we were able to show that the accumulation of Mn3O4-NPs in the MOB can induce the formation of SG in mitral neurons.

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‘Trojan-Horse’ stress-granule formation mediated by manganese oxide nanoparticles

Cited by 9 publications

References 41 publications

Stress Granules in the Anti-Cancer Medications Mechanism of Action: A Systematic Scoping Review

Stress Granules in the Anti-Cancer Medications Mechanism of Action: A Systematic Scoping Review

Plant mediated biosynthesis of Mn3O4 nanostructures and their biomedical applications

BGRS/SB-2022 681 The role of manganese oxide nanoparticles in the formation of stress granules in the mouse olfactory system

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