Trocheliolide B, a New Cembranoidal Diterpene from the Octocoral Sarcophyton Trocheliophorum

Abstract

A new cembranoidal diterpene, trocheliolide B (1), was isolated from the octocoral Sarcophyton trocheliophorum. The structure of 1 was elucidated on the basis of spectroscopic methods.

Immunomodulatory Biscembranoids and Assignment of Their Relative and Absolute Configurations: Data Set Modulation in the Density Functional Theory/Nuclear Magnetic Resonance Approach

“…In the course of an ongoing search for bioactive secondary metabolites from the South China Sea invertebrates, ,, the soft coral S. trocheliophorum was collected off the coast of Xisha, Sansha Province. This species has been reported to be the producer of compounds such as polyhydroxysterols, , sesquiterpenoids, cembrane diterpenoids, − and furanones. , This chemical examination on the Et 2 O extract of S. trocheliophorum led to the isolation of two known compounds glaucumolides A ( 1 ) and B ( 2 ), the absolute configurations of which were revised, and five new compounds named bistrochelides A–E ( 3 – 7 ) (Figure ). It is the first report of biscembranoids from the title animal.…”

The Soft Coral Sarcophyton trocheliophorum: A Warehouse of Terpenoids with Structural and Pharmacological Diversity

“…As revealed in the literature [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ], most of the chemically investigated S. trocheliophorum specimens were collected off the islands in the South China Sea and Indian Ocean, and off the coasts of Saudi Arabia, Egypt, and Australia. These collection sites can be divided into three sea waters: the Pacific Ocean, the Indian Ocean, and the Red Sea.…”

“…These collection sites can be divided into three sea waters: the Pacific Ocean, the Indian Ocean, and the Red Sea. Most of the specimens originated from the Pacific Ocean ( Table S1 ) [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. In this review, terpenoids from S. trocheliophorum were classified into three classes: sesquiterpenoids, diterpenoids, and biscembranoids.…”

“…In this review, terpenoids from S. trocheliophorum were classified into three classes: sesquiterpenoids, diterpenoids, and biscembranoids. Among them, diterpenoids were the most common terpenoids from this species, accounting for 89.1% of all descriptions in the literature ( Table S1 ) [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. These three terpenoid classes were further categorized based on their different skeletal types: trocheliopho...…”

Chemical Diversity in Species Belonging to Soft Coral Genus Sacrophyton and Its Impact on Biological Activity: A Review

“…Sarcophytrols R and S 276 and 277 revealed a unique decaryiol skeleton with an uncommon C12/C15 cyclization [88]. Another cembranoid, trocheliolide B 280 from S. trocheliophorum was isolated [89]. Chemical determination of S. trocheliophorum organic extract, yielded pyrane-based diterpene, 9-Hydroxy-10,11-dehydro-sarcotrocheliol 281 [90].…”