TrkB and TrkC Are Differentially Regulated by Excitotoxicity during Development of the Basal Ganglia

Checa, Núria; Canals, Josep M.; Gratacòs, Elena; Alberch, Jordi

doi:10.1006/exnr.2001.7796

Cited by 15 publications

(13 citation statements)

References 59 publications

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“…Its temporal expression also suggests that, NT-3 is not necessary as a differentiation or survival factor for striatal cells. In addition NT-3 activates a different type of neurotrophin receptors, the TrkC receptors 24. Alternatively, NT-3 may influence the same population BDNF affects during another developmental time as a result of different developmental strategies and developmental speed.…”

Section: Discussionmentioning

confidence: 99%

“…NT- 4/5 should arrive to the neostriatum between postnatal day 10 th and 21 st , however, it is not known where the NT-4/5 is coming from, or if it is produced inside of the nucleus by neostriatal cells. Nevertheless, differences in temporal expression between BNDF and NT-4/5 are important to note, because both neurotrophins activate the same TrkB receptor 24. It is possible that the actions of both neurotrophins are not the same, or NT-4/5 actions may substitute for BDNF actions on striatal cells.…”

Section: Discussionmentioning

confidence: 99%

“…NT-4/5 temporal expression at P21, P42 and P80, suggests a possible use of this neurotrophin in therapeutic manipulations because, it has been demonstrated that NT-4/5 increases the survival of GABA, calbindin and calretinin positive neurons in the neostriatum, and shares several of the BDNF neurotrophic effects because, it also acts on TrkB receptors 24, 30. Therefore, if BDNF exhibits a synthesis failure, which has been demonstrated in some degenerative illness 14, TrkB receptors might be activated with NT-4/5 to protect medium spiny neurons from cell death.…”

Section: Discussionmentioning

confidence: 99%

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Differential expression of neurotrophins in postnatal C57BL/6 mice striatum

Zermeño¹,

Espíndola²,

Mendoza³

et al. 2009

Int. J. Biol. Sci.

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Neurotrophin expression in early stages of development is crucial for brain assembly and function. In particular, postnatal expression of neurotrophins has not been well documented in the neostriatum and in general neurotrophins or their receptor mRNA's are normally reported, but not protein expression. In the present study, immunocytochemical expression of BDNF, NT-3 and NT-4/5 was characterized in striatal tissue of C57BL/6 mice at postnatal days 10 th (P10), 21 st (P21), 42 nd (P42) and 80 th (P80). We found that the expression of BDNF diminished along the postnatal time course we evaluated, while staining for NT-4 increased up to age P42 and remained constant, thereafter in the cell's soma. In contrast, NT-3 was first expressed in the neostriatal bundles and later on, in neostriatal cell somas. These results provide information about differences in the spatial and temporal expression of each neurotrophin in the neostriatum during the first 80 th postnatal days. RT-PCR procedures were also carried out to further determine whether protein levels of neurotrophins observed in the neostriatum were under control of gene expression. All neurotrophin mRNAs were expressed and only mRNA BDNF was reduced during the postnatal evaluated days. Differences in temporal expression of neurotrophins may be related to the heterochronic development of neostriatal cell populations, but also with the specificity of each neurotrophin modulating different neuronal targets.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Differential expression of neurotrophins in postnatal C57BL/6 mice striatum

Zermeño¹,

Espíndola²,

Mendoza³

et al. 2009

Int. J. Biol. Sci.

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“…2 Three main transcription factors involved in specification dopaminergic neurons – Nurr1 , Pitx3 and En1 – also regulate their survival. 52, 53, 54, 55 Both Nurr1 and Pitx3 were shown to activate expression of BDNF, 56, 57 which promotes survival of a subpopulation of dopaminergic neurons from E16 onward 36 via TrkB receptors 58, 59 (Figure 3c). …”

Section: Neuron Type-specific Pro-survival Mechanismsmentioning

confidence: 99%

Neuronal survival in the brain: neuron type-specific mechanisms

2017

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Neurogenic regions of mammalian brain produce many more neurons that will eventually survive and reach a mature stage. Developmental cell death affects both embryonically produced immature neurons and those immature neurons that are generated in regions of adult neurogenesis. Removal of substantial numbers of neurons that are not yet completely integrated into the local circuits helps to ensure that maturation and homeostatic function of neuronal networks in the brain proceed correctly. External signals from brain microenvironment together with intrinsic signaling pathways determine whether a particular neuron will die. To accommodate this signaling, immature neurons in the brain express a number of transmembrane factors as well as intracellular signaling molecules that will regulate the cell survival/death decision, and many of these factors cease being expressed upon neuronal maturation. Furthermore, pro-survival factors and intracellular responses depend on the type of neuron and region of the brain. Thus, in addition to some common neuronal pro-survival signaling, different types of neurons possess a variety of 'neuron type-specific' pro-survival constituents that might help them to adapt for survival in a certain brain region. This review focuses on how immature neurons survive during normal and impaired brain development, both in the embryonic/neonatal brain and in brain regions associated with adult neurogenesis, and emphasizes neuron type-specific mechanisms that help to survive for various types of immature neurons. Importantly, we mainly focus on in vivo data to describe neuronal survival specifically in the brain, without extrapolating data obtained in the PNS or spinal cord, and thus emphasize the influence of the complex brain environment on neuronal survival during development.

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“…The regulation of endogenous expression of these neurotrophic factors and their receptors after lesion suggests a role in the maintenance of cellular integrity and injury repair in the basal ganglia connectivity [52]. The expression of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) and their receptors, tropomyosin receptor kinase (trk)A, B and C, is differentially regulated in the striatum after intrastriatal injection of different iGluR and mGluR agonists during both postnatal development and in adulthood [106][107][108]. Furthermore, members of the GDNF family, GDNF and neurturin and their receptors, c-ret, glial cell line-derived neurotrophic factor receptor (GFR)α-1 and GFRα-2, are also selectively regulated in the striatum depending on the GluR stimulated [109].…”

Section: Neurotrophic Supportmentioning

confidence: 99%