Trk neurotrophin receptor-like proteins in the teleost Dicentrarchus labrax

Hannestad, Jonas; Marino, Fabio; Germanà, Antonino; Catania, Stefania; Abbate, Francesco; Ciriaco, E.; Vega, J. A.

doi:10.1007/s004410000181

Cited by 18 publications

(37 citation statements)

References 39 publications

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“…On the contrary, in our previous study TrkA-like ic were detected in renal tubules and collecting system of the adult teleost (de Girolamo et al 2000). Similar findings were obtained in alevin teleost (Hannestad et al 2000), in developing rat (Durbeej et al 1994) and adult human kidney (Shibayama and Koizumi 1996). The absence of TrkA IR in Rana may be explained by the possibility that the antibody used in this study does not recognize an amphibian variant of the TrkA, i.e., truncated forms, and/ or by a species specific difference.…”

Section: Discussionsupporting

confidence: 74%

“…Scarce TrkB-like IR was found in intermediate and distal tubules of lizard kidney and no IR was obtained in frog kidney. TrkB-like IR has been reported during post-larval stages in Dicentrarchus labrax kidney (Hannestad et al 2000) and in inductive mesenchyme of rat (Wheeler et al 1998) and human kidney (Huber et al 1996).TrkB-like IR was never detected in adult fish kidney (de Girolamo et al 2000) and in adult mammalian kidney (Shibayama and Koizumi 1996). Durbeej et al (1993) utilizing oligonucleotide probes for Trk, TrkB and TrkC, found only TrkB and TrkC in the developing rodent kidney.…”

Section: Discussionmentioning

confidence: 96%

“…Localization of TrkC has been detected in the epithelium of renal tubules in freshwater and seawater adult (de Girolamo et al 2000), and alevin teleost (Hannestad 2000), rat (Wheeler 1998) and man (Shibayama and Koizumi 1996). Scarce TrkB-like IR was found in intermediate and distal tubules of lizard kidney and no IR was obtained in frog kidney.…”

Section: Discussionmentioning

confidence: 97%

“…The antisera employed in this study against TrkA, TrkB and TrkC react with the tyrosine-kinase catalytic domain of the specific Trk mammalian proteins. In previous studies these antisera were used to identify the occurrence and distribution of the Trk receptor proteins in several organs of non-mammalian vertebrates (de Girolamo et al 2000;Hannestad et al 2000;Holmberg et al 2001;Lucini et al 1999Lucini et al , 2001, however they may not strictly discriminate between amphibian and reptile receptor subgroups.…”

Section: Discussionmentioning

confidence: 99%

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TRK neurotrophin receptor-like proteins in the kidney of frog ( Rana esculenta ) and lizard ( Podarcis sicula ): an immunohistochemical study

Girolamo

Arcamone

Lucini

et al. 2004

Anatomy and Embryology

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The present study investigates the occurrence of Trk-like neurotrophin receptor proteins in the lizard and frog kidney. In lizard rare TrkB-like immunoreactive cells in intermediate and distal tubules were found. TrkC-like immunoreactive cells were numerous in collecting tubules and became less numerous in collecting ducts. No TrkC-like immunoreactivity was detected in the ureteric duct. In the frog, we observed numerous TrkC-like immunoreactive cells in collecting tubules and ducts while they were scattered among negative epithelial cells in the wolffian duct. TrkB- and TrkA-like immunoreactivity was never found. Western blot analysis demonstrated that the frog and lizard kidney contains TrkC-like protein; TrkB-like protein was present only in the lizard kidney. These results demonstrate for the first time the occurrence of Trk-like proteins in the kidney of amphibians and reptiles, and aid in the assessment of the role of Trk receptor-like proteins in the kidney physiology of vertebrates.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

TRK neurotrophin receptor-like proteins in the kidney of frog ( Rana esculenta ) and lizard ( Podarcis sicula ): an immunohistochemical study

Girolamo

Arcamone

Lucini

et al. 2004

Anatomy and Embryology

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“…In adults, only the presence of ARTN immunoreactivity (IR) was recently described in zebrafish gut (Lucini et al 2004). However, previous findings suggest an involvement of other neurotrophic factors in fish gut Lucini et al 1999Lucini et al , 2003Hannestad et al 2000). Thus, the aim of this study was to investigate the presence and distribution of GDNF, NRTN, PSPN, and ARTN in the intestine of five adult teleostean species: bass, gilthead, scorpionfish, zebrafish, and trout.…”

Section: Introductionmentioning

confidence: 99%

GDNF family ligand immunoreactivity in the gut of teleostean fish

Lucini¹,

Maruccio²,

Tafuri³

et al. 2005

Anat Embryol

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Glial-derived neurotrophic factor (GDNF), neurturin (NRTN), persephin (PSPN), and artemin (ARTN) are a group of proteins belonging to the GDNF family ligands (GFLs). GDNF, NRTN, and ARTN support the survival of central, peripheral, and autonomic neuron populations, while PSPN supports the survival of only several central neuron populations. A common receptor, RET, modulates the action of this family and a co-receptor, GFRalpha, determines RET ligand specificity. GDNF and NRTN appear to be essential for enteric nervous system (ENS) development in mammals, zebrafish, and other teleostean species. GFLs are also essential for the maintenance and plasticity of adult mammalian ENS. In this study, the distribution pattern of GFLs in the intestine of five adult fish (bass, gilt-head, scorpionfish, trout, and zebrafish) was evaluated by immunochemical and immunocytochemical analysis. The results demonstrated the presence of GDNF, NRTN, and ARTN in the gut of all species studied. They appeared to be spread in the ENS and/or endocrine cells of the intestine. These findings suggest that the presence of GFLs in fish gut is not only limited to developmental period, but could be also involved in the enteric physiology of adult species.

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Brain‐derived neurotrophic factor: mRNA expression and protein distribution in the brain of the teleost Nothobranchius furzeri

D’Angelo

Girolamo

Lucini

et al. 2014

J of Comparative Neurology

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BDNF (brain-derived neurotrophic factor) is a member of the neurotrophin family and it is implicated in regulating brain development and function. The BDNF gene organization and coding sequence are conserved in all vertebrates. The present survey was conducted in a teleost fish, Nothobranchius furzeri, because it is an emerging model of aging studies due to its short lifespan and shows the high rate of adult neurogenesis typical of anamniotes. The present survey reports: 1) the identification and characterization of the cDNA fragment encoding BDNF protein, and 2) the localization of BDNF in the whole brain. BDNF mRNA expression was assessed by in situ hybridization, by employing an antisense RNA probe; BDNF protein was detected by employing a sensitive immunohistochemical technique, along with highly specific affinity-purified antibodies to BDNF. Both BDNF mRNA and protein were detected in neurons and glial cells of all regions of the brain of N. furzeri. Interestingly, BDNF was localized also in brain areas involved in adult neurogenic activities, suggesting a specific role for this neurotrophic factor in controlling cell proliferation. These results provide baseline information for future studies concerning BDNF involvement in the aging processes of the teleost brain.

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Trk neurotrophin receptor-like proteins in the teleost Dicentrarchus labrax

Cited by 18 publications

References 39 publications

TRK neurotrophin receptor-like proteins in the kidney of frog ( Rana esculenta ) and lizard ( Podarcis sicula ): an immunohistochemical study

TRK neurotrophin receptor-like proteins in the kidney of frog ( Rana esculenta ) and lizard ( Podarcis sicula ): an immunohistochemical study

GDNF family ligand immunoreactivity in the gut of teleostean fish

Brain‐derived neurotrophic factor: mRNA expression and protein distribution in the brain of the teleost Nothobranchius furzeri

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