“…It was further and considerable progress to extend this trick to a 1,4-selective addition reaction of organolithium reagents with a naphthalene nucleus. , Steric modification in a carbonyl moiety has been proven as an alternative methodology effective for a 1,4-selective conjugate addition of organolithium reagents . Pioneering works by Seebach and Cooke have demonstrated that sterically hindered α,β-unsaturated trityl ketones and BHA esters serve as the Michael acceptors, affording the corresponding 1,4-selective addition products . The BHA method was also extended to a 1,4-selective addition reaction of a naphthalenecarboxylate. , Steric masking and nucleophilic activation of naphthalenyl ketone by an external aluminum-based bulky Lewis acid has been impressive advance of 1,4- and 1,6-selective addition reactions .…”