Tritrichomonas foetus:Iron Acquisition from Lactoferrin and Transferrin

Tachezy, Jan; Kulda, Jaroslav; Bahnı́ková, Ivana; Suchan, Pavel; Rázga, Jakub; Schrével, Joseph

doi:10.1006/expr.1996.0068

Cited by 63 publications

(53 citation statements)

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“…The competition for iron between the parasite and lactoferrin is the basis of its antiparasitic activity against Pneumocystis carinii (Cirioni et al, 2000). In contrast, some parasites such as Tritrichomonas foetus are able to use lactoferrin as a donor of ferric ions (Tachezy et al, 1996).…”

Section: Antiparasitic Activitymentioning

confidence: 99%

Lactoferrin: a review

Adlerova¹,

Bartošková²,

Faldyna³

2008

Vet. Med.

261

217

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This review discusses the biological properties of the glycoprotein lactoferrin. Lactoferrin has been identified in secretions from exocrine glands and in specific granules of neutrophils. After degranulation, neutrophils become the main source of lactoferrin in blood plasma. Lactoferrin possesses various biological functions, including roles in iron metabolism, cell proliferation and differentiation, and antibacterial, antiviral, and antiparasitic activity. Many of these functions do not appear to be connected with its iron binding ability. Of late, lactoferrin concentrations have been measured mostly in humans but also in some other species. However, the relationship between its concentration and physiological or pathological effects on body functions is not yet well characterised.

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Section: Antiparasitic Activitymentioning

confidence: 99%

Lactoferrin: a review

Adlerova¹,

Bartošková²,

Faldyna³

2008

Vet. Med.

261

217

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show abstract

“…As an obligate parasite, T. foetus depends on endogenous bacteria and host secretions for nutrients such as iron. This organism has high iron requirements for in vitro cultivation (50-100 μM) [Tachezy et al, 1996], surpassing those of eukaryotic cells, although comparable to other anaerobic amitochondriate protists. T. foetus inhabits the vagina, cervix, and the lumen of the bovine uterus, with the last one being characterized as rich in TF [Roberts and Parker, 1974].…”

Section: Tritrichomonas Foetusmentioning

confidence: 90%

Transferrin Binding Proteins as a Means to Obtain Iron in Parasitic Protozoa

Reyes-López¹,

Serrano-Luna²,

Piña-Vázquez³

et al. 2012

Binding Protein

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“…In addition, the ability of Tritrichomonas foetus for the uptake of iron from the host environment may be a critical factor for its pathogenicity and virulence [21]. The parasite grows in the bovine vagina where lactoferrin is available and also invades the bovine uterus, where abundant transferrin exists [22].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Iron Supplementation on the Growth Rate and Antioxidant Activity of Trichomonas vaginalis

Razavi¹,

Foroudi²,

Rakhshandehroo³

et al. 2017

J Vet Sci Technol

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Trichomonas vaginalis is a common protozoan parasite found in females and males worldwide. The parasite causes mild to severe inflammations in the urogenital tract. This study was conducted to evaluate the effect of iron excess on the growth rate and the activity of antioxidant enzymes in T. vaginalis. The parasite was cultured in Diamond's Trypticase Yeast Maltose (TYM) media with and without iron supplementation and assessed at 2, 3, 5, 7, 9, 11, 13 and 15 days post inoculation (dpi). The results showed significant higher numbers of the parasite in medium with iron supplementation. Furthermore, our findings revealed higher activities of antioxidant enzymes (SOD, GPX and CAT) in parasites cultured with iron supplementation. In conclusion, the present experiment showed that iron increased not only the multiplication rate but also the antioxidant activities of T. vaginalis. It seems that iron could protect T. vaginalis from toxic oxygen metabolites during tissue invasion and helps the parasite to maintain its pathogenicity for the host.

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Tritrichomonas foetus:Iron Acquisition from Lactoferrin and Transferrin

Cited by 63 publications

References 0 publications

Lactoferrin: a review

Lactoferrin: a review

Transferrin Binding Proteins as a Means to Obtain Iron in Parasitic Protozoa

The Effects of Iron Supplementation on the Growth Rate and Antioxidant Activity of Trichomonas vaginalis

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