Triton-B Mediated One-Pot Multicomponent Synthesis of 3,5 Substituted Tetrahydro-2H-1,3,5-Thidiazine-2-Thiones

Abstract

A new-fangled, proficient, one-pot multi component, intramolecular C-S bond formation reaction, mediated by phase transfer catalyst, Triton-B, is described in this paper. The reaction of alkyl/ phenyl amines, CS2 and formaldehyde catalyzed via Triton-B resulted in formation of 3-(Alkyl or aryl methyl),5-(Alkyl or aryl methyl) substituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones compounds(1a-15a). These compounds (1a-15a) were characterized with the help of elemental analysis, IR, NMR and mass spectroscopic methods. The PTC mediated reactions require mild reaction condition and reduced time period for completion. The reaction is achieved at normal temperature under solvent free conditions with good yields and great selectivity. This methodology discourages the traditional synthesis method of inorganic base for such coupling reaction.