Abstract:SummaryThe mucolytic agent bromhexine is useful in the evaluation of the performance of inductively coupled plasma mass spectrometry (ICP-MS) as compared to radiolabelling. A prerequisite for this comparison is access to radiolabelled bromhexine. [ 3 H 2 ]-bromhexine was synthesized in three steps introducing tritium in the final step by reduction of 2-amino-3,5-dibromo-N-methyl-N-cyclohexylbenzamide. Good chemical yields, high specific activity (54 Ci/mmol) and high radiochemical purity (98.5%) were achieved.… Show more
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