Tritium-labelled alkaloids: Synthesis and applications

Filer, Crist N.

doi:10.1002/jlcr.3480

Cited by 10 publications

(3 citation statements)

References 174 publications

(285 reference statements)

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“…Five years ago, Filer published a review [88] dedicated to the synthesis and applications of the tritium-labeled [75] with the permission of Springer Nature alkaloids including indole alkaloids Reproduced with minor editing privilege from Vogt et al [83] with the permission of John Wiley and Sons enumeration of alkaloids is taken from the parent review). The author stated that "the extreme structural and functional variety of alkaloids has presented both valuable opportunities and complex synthetic challenges for their tritiation.…”

Section: Recent and Most Recent Resultsmentioning

confidence: 99%

“…Five years ago, Filer published a review [ 88 ] dedicated to the synthesis and applications of the tritium‐labeled alkaloids including indole alkaloids 1 – 6 , 8 ; quinoline and isoquinoline alkaloids 11 – 16 ; pyridine alkaloids 17 – 19 ; isoxazole alkalpids 20 – 22 ; tropane alkaloids exemplified with 23 ; pyrrolizidine alkaloids exemplified with 24 ; quinolizidine alkaloids 25 , 27 ; piperidine alkaloids exemplified with 28 ; steroidal alkaloids exemplified with 29 ; amaryllidaceae alkaloids 30 , 31 ; tropolone protoalkaloid 32 ; and marine toxin alkaloids 33 – 35 (for clarity, enumeration of alkaloids is taken from the parent review). The author stated that “the extreme structural and functional variety of alkaloids has presented both valuable opportunities and complex synthetic challenges for their tritiation.…”

Section: Recent and Most Recent Resultsmentioning

confidence: 99%

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Tritium NMR: A compilation of data and a practical guide

Krivdin

2023

Magnetic Reson in Chemistry

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The present review is focused on experimental methods and structural applications of tritium NMR. It consists of five parts covering accordingly, introduction, brief overview, early (based on the papers appearing before 2000), more recent (based on the papers appeared in the interim of 2000 to 2015), and recent (based on the papers that appeared after 2015) reports. A special interest in this review is focused on practical aspects of tritium NMR spectroscopy, which is thoroughly illustrated by its numerous applications in chemistry and biochemistry.

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Section: Recent and Most Recent Resultsmentioning

confidence: 99%

Section: Recent and Most Recent Resultsmentioning

confidence: 99%

Tritium NMR: A compilation of data and a practical guide

Krivdin

2023

Magnetic Reson in Chemistry

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“…Pure isocyanic acid was retained in the middle trap, and its quality was checked with gas‐phase IR spectroscopy (Bruker, Tensor 27). Isotopically‐labelled HN 13 CO and H 15 NCO were prepared from 13 C and 15 N‐labelled potassium cyanate, which were synthesized via reactions of potassium phenoxide with 13 C and 15 N‐labelled urea according to the literature procedure [21] …”

Section: Methodsmentioning

confidence: 99%

Spectroscopy and Photochemistry of [Al, N, C, O, H]: Connectivity to Aluminium‐Bearing Species in the Universe

Wang,

Jiang,

Sun

et al. 2024

Chemistry A European J

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Aluminium is one of the most abundant metals in the universe and impacts the evolution of various astrophysical environments. Currently detected Al‐bearing molecules represent only a small fraction of the aluminium budget, suggesting that aluminium may reside in other species. AlO and AlOH molecules are abundant in the oxygen‐rich supergiant stars such as VY Canis Majoris, a stellar molecular factory with 60+ molecules including the prebiotic NC‐bearing species. Additional Al‐bearing molecules with N, C, O, and H may form in O‐rich environments with radiation‐accelerated chemistry. Here, we present spectroscopic identification of novel aluminium‐bearing molecules composed of [Al, N, C, O, H] and [Al, N, C, O] from the reactions of Al atoms and HNCO in solid argon matrix, which are potential Al‐bearing molecules in space. Photoinduced transformations among six [Al, N, C, O, H] isomers and three [Al, N, C, O] isomers, along with their dissociation reactions forming the known interstellar species, have been disclosed. These results provide new insight into the chemical network of astronomically detected Al‐bearing species in space.

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Iridium‐Catalyzed CH Functionalizations with Hydrogen Isotopes

Derdau

2022

Handbook of CH-Functionalization

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This overview discusses some highlights of iridium catalyzed CH functionalizations with hydrogen isotopes. The hydrogen isotope exchange (HIE) reaction has become the gold standard in late stage functionalization and synthesis of deuterium or tritium labelled organic, complex molecules. In particular, new highly selective and reactive protocols in the areas of acid/base, nanoparticle, metal‐ catalyzed or photoredox catalysis are reported.

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Tritium-labelled alkaloids: Synthesis and applications

Abstract: This review discusses the synthetic methods used to tritiate nonmorphinan alkaloids as well as their applications.

Cited by 10 publications

References 174 publications

Tritium NMR: A compilation of data and a practical guide

Tritium NMR: A compilation of data and a practical guide

Spectroscopy and Photochemistry of [Al, N, C, O, H]: Connectivity to Aluminium‐Bearing Species in the Universe

Iridium‐Catalyzed CH Functionalizations with Hydrogen Isotopes

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