TRITERPENOIDS OF<i>ADENANTHERA PAVONINA</i>BARK

Yadav, Neerja; Misra, G.; Nigam, S. K.

doi:10.1055/s-0028-1097649

Cited by 22 publications

(10 citation statements)

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“…The leaves possess octacosanol, dulcitol, glucosides of β-sitosterol and stigmasterol. The bark furnishes stigmasterol glucoside, and pods contain glycosides, saponins and steroids [9][10][11] . A new five-membered lactone ring with an exo-cyclic double bonded compound, pavonin was isolated from the its methanol soluble part 12 .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Evaluation of Scavenging Activity of Methanolic Extract of Adenanthera Pavonina Linn Leaves

Mujahid

2015

J. Drug Delivery Ther.

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Aim: Reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide and hydroxyl radicals are involved in the oxidative damages resulting in pathogenesis of the various disorders and diseases. Thus, the scavenging activity of methanolic extract of Adenanthera pavonina Linn leaves (MEAP) was evaluated to find the ability to counteract oxidative damages by ROS. Materials and methods: Total phenolic and flavonoid contents were determined by colorimetric principle using gallic acid and rutin calibration curves respectively. Scavenging activity was evaluated by DPPH free radical and nitric oxide anion scavenging assays. Total reducing power was also evaluated. Results: Phytochemical analysis of MEAP showed the presence of alkaloids, glycosides, carbohydrates, phenolic compounds, tannins, flavonoids, terpenoids, saponins, sterols, proteins and resins. Total ash, acid insoluble and water soluble ash values were found to be 8.86, 2.24 and 7.18% w/w respectively. Loss on drying was found to be 1.53% w/w. Extractive value was found to be 11.2% w/w. Total phenolic and flavonoid contents in MEAP were found to be 55.43±1.07 µg/ml equivalent to gallic acid and 52.87±1.8 µg/ml equivalent to rutin. The IC 50 values for the scavenging of DPPH free radical and nitric oxide anion were found to be 425 µg/ml and 352 μg/ml as compared to that of standard ascorbic acid 320 μg/ml and 280 μg/ml respectively. Total reducing power was found to be increasing with increasing doses of extract. Conclusion: Methanolic extract of Adenanthera pavonina Linn leaves is a potent scavenger of ROS and can counteract oxidative damages by ROS. Thus, MEAP can be employed as an anti-oxidant drug to counteract and treat oxidative damages by ROS.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Evaluation of Scavenging Activity of Methanolic Extract of Adenanthera Pavonina Linn Leaves

Mujahid

2015

J. Drug Delivery Ther.

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“…Traditionally, the ground seed is widely used for the treatment of various human ailments such as treatment of boils, inflammation, blood disorders, arthritis, rheumatism, cholera, paralysis, epilepsy, convulsion, spasm and indigestion (Burkill 1966 ; Balogun and Fetuga 2004 ). Phytochemically, the seed and pod contain glycosides, saponins and steroids (Howes 1974 ; Yadav et al 1976 ). A new five-membered lactone ring compound, pavonin was isolated from the methanol soluble part of A. pavonina (S.A.Muhammad et al 2005 ), oil extracted from the seed has been reported to have membrane-stabilizing activity by reducing lytic effect on erythrocytes, exhibited by many intravenous drugs (Anna et al 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-hyperglycaemic and lipid lowering potential of Adenanthera pavonina Linn. in streptozotocin induced diabetic rats

Pandhare

Sadasivam

Mohite³

et al. 2012

Orient Pharm Exp Med

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In India, Adenanthera pavonina is traditionally used in the treatment of diabetes mellitus and lipid disorders. In the present study, the antihyperglycaemic and lipid lowering effect of Adenanthera pavonina seed aqueous extract (APSAE) was evaluated using streptozotocin induced diabetes in rats. Streptozotocin was given at the dose of 55 mg/kg, i.p. After induction of diabetes, APSAE was administered for 30 days p. o. and simultaneously different biochemical parameters like plasma glucose, HbA1c, serum triglyceride, cholesterol, LDL-cholesterol and HDL-cholesterol were estimated. Diabetic control showed significant increase (P < 0.01) in plasma glucose, serum triglyceride, cholesterol, LDL-cholesterol and significant decrease (P < 0.01) in serum HDL-cholesterol and HbA1c. Treatment with APSAE showed significant reduction (P < 0.01) in plasma glucose when compared with diabetic control. The elevated levels of serum triglyceride and cholesterol levels were significantly reduced (P < 0.01) by APSAE. APSAE treatment for 30 days showed significant decrease in serum LDL-cholesterol (P < 0.01) and significant increase in serum HDL cholesterol level (P < 0.01). Moreover, diabetic control there was significant decrease in HbA1c which was significantly increased (P < 0.05) by treatment with APSAE. Hence, from the result obtained in the present study it can be confirmed that Adenanthera pavonina has the potential to treat diabetes condition and associated lipid disorders.

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“…Traditionally, the ground seed is widely used for the treatment of various human ailments such as treatment of boils, inflammation, blood disorders, arthritis, rheumatism, cholera, paralysis, epilepsy, convulsion, spasm and indigestion (Burkill, 1966;Balogun & Fetuga, 2004). Phytochemically, the seed and its pod contain glycosides, saponins and steroids (Howes, 1974;Yadav et al, 1976). A new five-membered lactone ring compound, parvonin was isolated from the methanol soluble part of A. pavonina oil extracted from the seed has been reported to have membrane-stabilizing activity by reducing lytic effect on erythrocytes, exhibited by many intravenous drugs (Muhammad et al, 2005;Anna et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Attenuating effect of seeds of Adenanthera pavonina aqueous extract in neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effects

Pandhare¹,

Sadasivam²,

Mohite³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The aim of present study was to investigate the attenuating effects of Adenanthera pavonina L., Leguminosae-Mimosaceae seeds aqueous extract (APSAE), in streptozotocin (STZ)-induced diabetic neuropathy in rats. APSAE (50, 100 and 200 mg/kg per day) was given to diabetic rats for twelve weeks. Cold and hot water tail immersion tests, photoactometer and Rota-rod tests were performed to assess degree of colder, thermal, spontaneous motor activity and motor co-ordination changes respectively at different time intervals i.e., week 0, 4, 8 and 12. Tissue superoxide anion and total calcium levels were determined after twelve weeks to assess biochemical alterations. Histopathological evaluations of sciatic nerve were also performed to assess nerve damage. APSAE treatment increased tail fl ick latency signifi cantly in diabetic rats. APSAE also reduced superoxide anion and total calcium levels. These results suggested that APSAE has attenuated development of diabetic neuropathy in streptozotocin-induced diabetic rats when compared with pregabalin (10 mg/kg, p.o.) and could be benefi cial in preventing the progression of diabetic nephropathy.

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TRITERPENOIDS OFADENANTHERA PAVONINABARK

Abstract: A. pa v o n i n a bark yielded saponin having glucose as the sugar moiety and oleanolic a n d echinocystic acids as sapopenins. These acids were also isolated in free state, besides stigmnsterol glucoside.

Cited by 22 publications

References 1 publication

Phytochemical Analysis and Evaluation of Scavenging Activity of Methanolic Extract of Adenanthera Pavonina Linn Leaves

Phytochemical Analysis and Evaluation of Scavenging Activity of Methanolic Extract of Adenanthera Pavonina Linn Leaves

Anti-hyperglycaemic and lipid lowering potential of Adenanthera pavonina Linn. in streptozotocin induced diabetic rats

Attenuating effect of seeds of Adenanthera pavonina aqueous extract in neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effects

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