Triterpenoids from Prunella vulgaris

Kojima, Hisashi; Ogura, Haruo

doi:10.1016/0031-9422(86)88033-5

Cited by 116 publications

(70 citation statements)

References 9 publications

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“…This herb with antioxidant, antimicrobial and anti-inflammatory properties has a long history of use as a remedy for cardiovascular diseases [29,30] . Phytochemical analyses showed that ursolic acid, oleanolic acid and their glycoside derivatives were the major components of P vulgaris L [31] . Commonly, the glycoside derivatives tend to be metabolized to their aglycone by intestinal bacterial deglycosylation after oral administration, and the metabolites are easily absorbed by the intestines due to the increase of hydrophobicity [32,33] .…”

Section: Discussionmentioning

confidence: 99%

Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+-ATPase

Chen¹,

Chung²,

et al. 2010

Acta Pharmacol Sin

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Aim: To examine if steroid-like compounds found in many Chinese medicinal products conventionally used for the promotion of blood circulation may act as active components via the same molecular mechanism triggered by cardiac glycosides, such as ouabain. Methods: The inhibitory potency of ouabain and the identified steroid-like compounds on Na + /K + -ATPase activity was examined and compared. Molecular modeling was exhibited for the docking of these compounds to Na + /K + -ATPase. Results: All the examined steroid-like compounds displayed more or less inhibition on Na + /K + -ATPase, with bufalin (structurally almost equivalent to ouabain) exhibiting significantly higher inhibitory potency than the others. In the pentacyclic triterpenoids examined, ursolic acid and oleanolic acid were moderate inhibitors of Na + /K + -ATPase, and their inhibitory potency was comparable to that of ginsenoside Rh2. The relatively high inhibitory potency of ursolic acid or oleanolic acid was due to the formation of a hydrogen bond between its carboxyl group and the Ile322 residue in the deep cavity close to two K + binding sites of Na + /K + -ATPase. Moreover, the drastic difference observed in the inhibitory potency of ouabain, bufalin, ginsenoside Rh2, and pentacyclic triterpenoids is ascribed mainly to the number of hydrogen bonds and partially to the strength of hydrophobic interaction between the compounds and residues around the deep cavity of Na + /K + -ATPase. Conclusion: Steroid-like compounds seem to contribute to therapeutic effects of many cardioactive Chinese medicinal products. Chinese herbs, such as Prunella vulgaris L, rich in ursolic acid, oleanolic acid and their glycoside derivatives may be adequate sources for cardiac therapy via effective inhibition on Na + /K + -ATPase.

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Section: Discussionmentioning

confidence: 99%

Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+-ATPase

Chen¹,

Chung²,

et al. 2010

Acta Pharmacol Sin

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“…The contents of ursolic acid 1 and oleanolic acid 2 in the P. vulgaris are much higher than those of other triterpenoids [7] [8], which are obviously correlated with the pharmacological action of the plant [9]- [11].…”

Section: Triterpenoidsmentioning

confidence: 99%

Research Progress on the Chemistry and Pharmacology of Prunella vulgaris Species

Ge¹,

Wang²,

Zhang³

et al. 2014

OALib

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An exhaustive literature survey on the secondary metabolites of widely distributed Prunella vulgaris L. species has been carried out. Triterpenoids, sterols, phenylpropanoids, flavonoids, coumarins, fatty acids, volatile oils and carbohydrates along with some other compounds, have been reported from this species. Many of these compounds have been found to possess significant biological properties, including antihypertensive activity, anticancer activity, anti-lipidemic activity, antibacterial and antivirus activities, anti-inflammatory activities, hypoglycemic effects, heptaprotective effects, antineoplastic activities, etc. P. vulgaris might offer a rich natural source with relative cheap price for developing new anti-neoplastic drugs.

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“…그러나 혈관벽이 손상을 받게 되면 평형상태가 깨지고 혈액 중의 혈소판이 점착, 활성화, 응집되고 응고계 활성화가 일어나 급속한 혈전을 형성하게 된다 [15]. 혈전증은 [11]. 최근까지의 생리활성연 구로는 항 HIV (human immunodeficiency virus) [9,12,18], 항염증 [8,19], 항알러지 [1,16], 항산화 [13,19], 항HSV (herpes simplex virus) [24], 항돌연변이 [14] [17,19,26].…”

Section: 서 론unclassified

Antithrombotic and Antiplatelet Activity of Extract from Prunella vulgaris

양원경¹,

성윤영²,

김호경³

2011

Journal of Life Science

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This study was performed to develop effective antithrombotic agents from traditional herb extracts.Prunella vulgaris L. has been used traditionally as a medical resource in cancer therapy, as well as treatment of hypertension and inflammation, and as a diuretic. However, the effects of Prunella vulgaris on thrombosis and platelet activation have not been clearly understood. Antithrombotic and antiplatelet activities of oriental medicinal herbs were investigated by evaluating the effect of the aqueous extract from Prunella vulgaris on the blood coagulation, platelet aggregation and fibrinolysis. Prunella vulgaris extracts showed effective anticoagulant activity in coagulation times such as activated partial thromboplastin time (APTT) and prothrombin time (PT). Prunella vulgaris also inhibited adenosine diphosphate (ADP)-and collagen-induced platelet aggregation. In addition, evaluation of fibrinolytic activity showed that the Prunella vulgaris extracts have high solubility. From these results, it is suggested that Prunella vulgaris can be a potential candidate for anticoagulants and antiplatelets, as well as fibrinolytic agents.

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Triterpenoids from Prunella vulgaris

Cited by 116 publications

References 9 publications

Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+-ATPase

Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+-ATPase

Research Progress on the Chemistry and Pharmacology of Prunella vulgaris Species

Antithrombotic and Antiplatelet Activity of Extract from Prunella vulgaris

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