Triterpenoids from Protorhus longifolia Exhibit Hypocholesterolemic Potential via Regulation of Cholesterol Biosynthesis and Stimulation of Low-Density Lipoprotein Uptake in HepG2 Cells
Musawenkosi Ndlovu,
June C. Serem,
Mamoalosi A. Selepe
et al.
Abstract:The increasing incidence of hypercholesterolemia-related
diseases
even in the presence of the currently available cholesterol-lowering
drugs indicates a need to discover new therapeutic drugs. This study
aimed to investigate the hypocholesterolemic potential of two triterpenoids
isolated from Protorhus longifolia stem
bark. In silico techniques and in vitro enzyme assays were used to evaluate the potential inhibition of
cholesterol esterase and HMG-CoA reductase by the triterpenoids (ARM-2
and RA-5). The toxic… Show more
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