Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice

Yin, Yongxia; Zhang, Yanguo; Li, Haijun; Zhao, Yan; Cai, Enbo; Zhu, Hongyan; Li, Pingya; Liu, Jinping

doi:10.1016/j.biopha.2018.10.160

Cited by 26 publications

(18 citation statements)

References 46 publications

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“…JNK activation has a vital role in mediating APAP-induced hepatic damage in mice [41,42]. Recent studies also demonstrated that the protection against APAP-induced liver injury was mediated by suppressing the activation of MAPK signaling pathways [43,44]. Similarly, in this research, the elevated phosphorylation of ERK1/2, JNK, and p38 in liver tissues were observed at 24 h after APAP treatment.…”

Section: Discussionsupporting

confidence: 69%

Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice

et al. 2018

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Baicalein (BAI), one of the main components of Scutellaria baicalensis Georgi, possesses numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and anti-bacterial activities. The purpose of this study was to evaluate the hepatoprotective effect of baicalein against acetaminophen (APAP)-exposed liver injury in mice, and elucidate the underlying hepatoprotective mechanism. Baicalein pretreatment significantly alleviated the elevation of IL-6, IL-1β and TNF-α in serum and hepatic in a dose-dependent manner. It also dose-dependently reduced the hepatic malondialdehyde (MDA) concentration, as well as the depletion of hepatic superoxide dismutase (SOD), hepatic glutathione (GSH) and hepatic catalase (CAT). Moreover, pretreatment with baicalein significantly ameliorated APAP-exposed liver damage and histological hepatocyte changes. Baicalein also relieved APAP-induced autophagy by regulating AKT/mTOR pathway, LC3B and P62 expression. Furthermore, the hepatoprotective effect of baicalein to APAP-induced liver injury involved in Jak2/Stat3 and MAPK signaling pathway. Taken together, our findings suggested that baicalein exhibits the ability to prevent liver from APAP-induced liver injury and provided an underlying molecular basis for potential applications of baicalein to cure liver injuries.

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Section: Discussionsupporting

confidence: 69%

Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice

et al. 2018

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“…ALI, which is caused by a number of factors, such as toxic chemicals, drugs, viruses, and bacteria, seriously threatens human health [1,4]. Recently, great attention and effort have been devoted to discovering phytochemicals with preventive or therapeutic effects against ALI [6,7,11,12,16,17,30]. In the current study, we found that ZER exhibits a hepatoprotective activity against CCl 4 -induced ALI by reducing the level of oxidative stress and inhibiting the inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

“…CCl 4 intoxication also causes localized necrosis of liver tissues, followed by the activation of Kupffer cells [10]. Together with the damaged hepatocytes, the activated Kupffer cells release chemokines and inflammatory cytokines, such as TNF-α and IL-6, which lead to an inflammatory response [7,11,12]. Healthy inflammation helps to clear the necrotic cell debris and stimulate regeneration of hepatocytes, however, unregulated inflammatory response can provoke further hepatic damage [13].…”

Section: Introductionmentioning

confidence: 99%

Zerumbone Protects against Carbon Tetrachloride (CCl4)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving the TLR4/NF-κB/COX-2 Pathway

Wang

Niu

et al. 2019

Molecules

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The natural compound Zerumbone (hereinafter referred to as ZER), a monocyclic sesquiterpenoid, has been reported to possess many pharmacological properties, including antioxidant and anti-inflammatory properties. This study aimed to investigate the underlying mechanism of ZER against acute liver injury (ALI) in CCl4-induced mice models. ICR mice were pretreated intraperitoneally with ZER for five days, then received a CCl4 injection two hours after the last ZER administration and were sacrificed 24 h later. Examination of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and the histopathological analysis confirmed the hepatoprotective effect of ZER. Biochemical assays revealed that ZER pretreatment recovered the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), restored the glutathione (GSH) reservoir, and reduced the production of malondialdehyde (MDA), all in a dose-dependent manner. Furthermore, administration of ZER in vivo reduced the release amounts of pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) and inhibited the increased protein levels of Toll-like receptor 4 (TLR4), nuclear factor-kappaB (NF-κB) p-p65, and cyclooxygenase (COX-2). Further studies in lipopolysaccharide (LPS)-induced Raw264.7 inflammatory cellular models verified that ZER could inhibit inflammation via inactivating the TLR4/NF-κB/COX-2 pathway. Thus, our study indicated that ZER exhibited a hepatoprotective effect against ALI through its antioxidant and anti-inflammatory activities and the possible mechanism might be mediated by the TLR4/NF-κB/COX-2 pathway. Collectively, our studies indicate ZER could be a potential candidate for chemical liver injury treatment.

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“…Sorbus pohuashanensis (Hance) Hedl. , a small deciduous tree of the subfamily Maloideae of Rosaceae, is a native tree species and widely distributed at altitudes of 900-2,500 m in northern China 26 . With beautiful flowers, colorful fruits, and leaves of different colors in the four seasons, S. pohuashanensis has a very high ornamental significance in landscape 27 .…”

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confidence: 99%

“…With beautiful flowers, colorful fruits, and leaves of different colors in the four seasons, S. pohuashanensis has a very high ornamental significance in landscape 27 . In addition, S. pohuashanensis has specific medicinal and commercial significance 26,28 . Research on S. pohuashanensis has in recent years focused on plant secondary structure and affinities 29 , phylogenetic relationships of pink-fruit 30 , seed germination and dormancy characteristics 31 , nutritional and medicinal components of the fruit 26,32 , identification of pathogenic pathogens and development and application of SSR markers 27,33 .…”

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confidence: 99%

Physiological and transcriptomic analyses characterized high temperature stress response mechanisms in Sorbus pohuashanensis

Pei

Zhang

Zhu

et al. 2021

Sci Rep

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Sorbus pohuashanensis (Hance) Hedl. is a Chinese native alpine tree species, but the problem of introducing S. pohuashanensis to low altitude areas has not been solved. In this study, we aimed to explore the molecular regulatory network of S. pohuashanensis in response to high-temperature stress using RNA-Sequencing technology and physiological and biochemical determination. Based on transcriptomic data, we obtained 1221 genes (752 up-regulated and 469 down-regulated) that were differentially expressed during 8 h 43℃ treatment and candidate genes were related to calcium signaling pathway, plant hormone signal transduction, heat shock factors, chaperones, ubiquitin mediated proteolysis, cell wall modification, ROS scavenging enzymes, detoxification and energy metabolism. The analysis of high temperature response at the physiological level and biochemical level were performed. The chlorophyll fluorescence parameters of leaf cells decreased, the content of osmotic regulators increased, and the activity of ROS scavenging enzymes decreased. The molecular regulatory network of S. pohuashanensis in response to high-temperature stress was preliminarily revealed in this study, which provides fundamental information improving introducing methods and discovering heat-tolerant genes involved in high-temperature stress in this species and provides a reference for other plants of the genus Sorbus.

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Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice

Cited by 26 publications

References 46 publications

Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice

Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice

Zerumbone Protects against Carbon Tetrachloride (CCl4)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving the TLR4/NF-κB/COX-2 Pathway

Physiological and transcriptomic analyses characterized high temperature stress response mechanisms in Sorbus pohuashanensis

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