Triterpenoids from Cornus capitata☆

Bhakuni, R. S.; Shukla, Y. N.; Thakur, Raghunath S.

doi:10.1016/s0031-9422(00)83888-1

Cited by 21 publications

(33 citation statements)

References 9 publications

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“…It possesses antibacterial and antifungal properties . The major fraction of the leaf extracts were identified and reported to contain carbonyl, phenolic, and amino groups which may be the reason for the successful reduction of metal ions into metal particles . As this herbal plant exhibits different pharmacological applications, it has been selected for the synthesis of AuNPs for biomedical and medical‐textile applications.…”

Section: Introductionmentioning

confidence: 99%

Green biosynthesis of gold nanoparticles using Croton sparsiflorus leaves extract and evaluation of UV protection, antibacterial and anticancer applications

Boomi

Poorani²,

Selvam

et al. 2020

Applied Organom Chemis

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Our study reports greener synthesis of gold nanoparticles (AuNPs) tethered to the extract of Croton sparsiflorus and in vitro evaluation of UV‐protection, antibacterial and anticancer activities. Sophisticated instrumental analytical techniques such as UV–vis spectrophotometer, FT‐IR, XRD, FE‐SEM, and TEM were employed for the existence and confirmation of the nanoparticles. FT‐IR and HPLC analysis were executed in the identification of the plausible functional groups implicated in the reduction of gold ions to AuNPs. UV protection property and antibacterial action of AuNPs‐coated cotton fabric were also presented. Moreover, in vitro anticancer evaluation against HepG2 cell line was conducted by MTT assay for Croton sparsiflorus extract derived AuNPs in different concentrations (50 to 150 μg/ml). Thus, the results of this work revealed that greener synthesized AuNPs exhibited good therapeutic applications as UV‐protection, antibacterial and anticancer agents.

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Section: Introductionmentioning

confidence: 99%

Green biosynthesis of gold nanoparticles using Croton sparsiflorus leaves extract and evaluation of UV protection, antibacterial and anticancer applications

Boomi

Poorani²,

Selvam

et al. 2020

Applied Organom Chemis

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“…(Cornaceae) is widely available in different regions of the world such as China and India. Studies have shown that it has several constituents present in its aerial parts such as cornin and phlorin from leaves, others include n-hentriacontane, 7-hydrocadeline, triacontanol, stigmastranone, lupeol, triacontanoic acid, betulin, epibetulin, betulinic acid, epibetulinic acid, tetracosanoic acid, maslinic acid, arjunolic acid, sitosterol-β-D-glucoside, gallic acid isolated from stem [ 6 , 7 ]. It is used as fuel, for animal bedding and its fruits are edible [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of the α-glucosidase inhibitory potential of methanolic extracts of traditionally used antidiabetic plants

Bhatia

Singh

Arora³

et al. 2019

BMC Complement Altern Med

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BackgroundDifferent plant parts of Roylea cinerea (D. Don) Baill. (Lamiaceae), Clematis grata Wall. (Ranunculaceae), Cornus capitata Wall. (Cornaceae) are traditionally used in the management of diabetes and various other diseases.MethodThe air-dried plant parts from different plants were coarsely powdered and macerated in methanol to obtain their crude extracts. The crude extracts were evaluated for their α-glucosidase inhibitory activity. On the basis of results obtained, the methanolic crude extract of Cornus capitata Wall. was further sequentially fractionated in hexane, diethyl ether, ethyl acetate, n-butanol. Fractions obtained were also evaluated for their α-glucosidase inhibitory potential. The kinetic study was performed using Lineweaver Burk plot to evaluate the type of inhibition. Furthermore, in silico analysis was also carried with active sites of the enzyme (PDB ID: 3WY1) using Autodock4.ResultsAmong all the plant extracts, Cornus capitata extract showed maximum inhibitory activity. Therefore its methanolic extract was further fractionated with the help of different solvents and the maximum activity was shown by the ethyl acetate fraction (IC50 50 μg/mL). Kinetic analysis indicated that Vmax and Km were increased indicating a competitive type of inhibition. In docking studies, among different constituents known in this plant, betulinic acid showed minimum binding energy (− 10.21 kcal/mol). The kinetic and docking studies have strengthened the observation made in the present study regarding the α-glucosidase inhibitory activity of Cornus capitata.ConclusionThe study provided partial evidence for pharmacological basis regarding clinical applications of Cornus capitata in the treatment of diabetes suggesting it to be a suitable candidate for the treatment of postprandial hyperglycemia.Electronic supplementary materialThe online version of this article (10.1186/s12906-019-2482-z) contains supplementary material, which is available to authorized users.

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“…In the IR spectrum, the broad absorption bands at 3400 and 1712 cm 21 were indicative of the hydroxyl functionality and cyclohexanone moiety in the molecule. In addition, the bands at 1635, 1600, and 870 cm 21 indicated the presence of double bonds and an isopropenyl side chain [13,14]. The 1 H NMR spectrum of 2 exhibited two twoproton broad singlets at d 2.20 and 2.10, respectively, attributable to methylene, adjacent to the carbonyl group, three broad singlets at d 0.77, 0.98, and 1.02, respectively, integrating for three protons each ascribable to C-18, C-19, and C-20 methyl groups.…”

Section: Resultsmentioning

confidence: 99%