Triterpenoids as reversal agents for anticancer drug resistance treatment

Yan, Xiaojian; Gong, Lihua; Zheng, Fang; Cheng, Kejun; Chen, Zhe‐Sheng; Shi, Zhi

doi:10.1016/j.drudis.2013.07.018

Cited by 61 publications

(48 citation statements)

References 55 publications

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“…It was suggested that silencing of survivin could sensitize cancer cells to chemotherapeutic agents. 36,37 This leads to generation of tumor-specific cytotoxic T lymphocytes, decreases tumor growth, and has been shown to be potentially beneficial in the treatment of large cell lymphomas. 38 Antisense oligonucleotides that reduce survivin expression in tumor cells induce apoptosis, decrease colony formation in soft agar, and sensitize tumor cells to chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Role of Survivin and p53 Expression in Response of Primary Culture of Ovarian Cancer Cells to Treatment With Chemotherapeutic Agents

Chawla

Kar²,

Gupta³

et al. 2018

International Journal of Gynecological Cancer

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Section: Discussionmentioning

confidence: 99%

Role of Survivin and p53 Expression in Response of Primary Culture of Ovarian Cancer Cells to Treatment With Chemotherapeutic Agents

Chawla

Kar²,

Gupta³

et al. 2018

International Journal of Gynecological Cancer

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“…It was reported that silence of survivin could sensitize ovarian cancer cells to chemotherapeutical agents4647. Inhibition of survivin by DHM might facilitate the sensitization to chemotherapeutical agents.…”

Section: Discussionmentioning

confidence: 99%

Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin

Wang

Chan

et al. 2017

Sci Rep

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Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industry and medicine for a long time. However, little is known about the effects of DHM on ovarian cancer and the underlying mechanisms. In this study, we demonstrated that DHM could effectively inhibit the proliferation of ovarian cancer cells and induce cell apoptosis. Survivin, an inhibitor of apoptosis (IAPs) family member, exhibited a decreased expression level after DHM treatment, which may be attributed to the activation of p53. Moreover, DHM markedly sensitized paclitaxel (PTX) and doxorubicin (DOX) resistant ovarian cancer cells to PTX and DOX by inhibiting survivin expression. Collectively, our findings highlight a previously undiscovered effect of DHM, which induces apoptosis and reverses multi-drug resistance against ovarian cancer cells through downregulation of survivin.

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“…Melting points were measured on a RY-1 melting point apparatus. 1 H-and 13 C-NMR spectra were recorded on a Bruker AV-500 (500/125 MHz for 1 H/ 13 C) spectrometer. Chemical shifts are reported as values from an internal tetramethylsilane standard.…”

Section: Methodsmentioning

confidence: 99%

Conjugation of Uridine with Oleanolic Acid Derivatives as Potential Antitumor Agents

Cheng

Huang

et al. 2016

Chem Biol Drug Des

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According to fused two bioactive moieties together by bonds covalently and available as a new single hybrid entity known as pharmacophore hybridization, a total of 10 targeted uridine-oleanolic acid hybrids were synthesized. Most of these hybrids showed excellent proliferation inhibition against tested Hep-G2, A549, BGC-823, MCF-7, and PC-3 tumor cell lines (IC50 < 8 μm), even with some IC50 values under 0.1 μm. The detection of cytotoxicity selectivity revealed that hybrids 5 and 18 exhibited low cytotoxicity toward normal human liver cell HL-7702. Further studies revealed that selected hybrid 5 could induce apoptosis in Hep-G2 cells through the investigation of acridine orange/ethidium bromide, Hoechst 33258 fluorescence stainings, and annexin V/propidium iodide assay. It was also found that hybrid 5 could induce mitochondrial membrane potential disruption, arrest Hep-G2 cell line at G1 phase, and activate effector caspase-3/9 to trigger cell apoptosis.

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Triterpenoids as reversal agents for anticancer drug resistance treatment

Cited by 61 publications

References 55 publications

Role of Survivin and p53 Expression in Response of Primary Culture of Ovarian Cancer Cells to Treatment With Chemotherapeutic Agents

Role of Survivin and p53 Expression in Response of Primary Culture of Ovarian Cancer Cells to Treatment With Chemotherapeutic Agents

Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin

Conjugation of Uridine with Oleanolic Acid Derivatives as Potential Antitumor Agents

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