Triterpenoids as Neutrophil Elastase Inhibitors

Abstract

Neutrophile elastase has the capacity to degrade elastin, a protein found in the connective tissue of the lungs. Unchecked elastase leads to pulmonary pathologies. Therefore, the development of elastase inhibitors is currently actively pursued in the therapeutic field. Several triterpenoids have been reported as inhibitors against elastase or its release. Such compounds could be valuable for the design of new drugs. This review is aimed at giving a comprehensive insight into the recent work performed in the field of triterpenoid-induced elastase inhibition.

In Silico Analysis of Cissus rotundifolia Constituents as Human Neutrophil Elastase (HNE), Matrix Metalloproteinases (MMP 2 and MMP 9), and Tyrosinase Inhibitors

“…However, three ligands (astragalin, beta amyrin, and formononetin) did not exhibit any interaction with amino acid residues of HNE. Beta amyrin has been reported to inhibit neutrophil elastase [24], which was good agreement which agrees with the present study. Similarly, bergenin has been reported to have anti-inflammatory activity [25].…”

Neutrophil Elastase Inhibitors and Chronic Kidney Disease

“…NSPs from Musca domestica (MDSPI16) 93 and from spider Araneus ventricosus (AvCI) 94 showed to be active in inhibiting elastase activity. The fungus Ganoderma mastoporum , found in several Asian countries, has inhibitory effects on elastase release and on superoxide anion generation, due to their content in triterpnoid, which are under studies as potential NE inhibitors 95 96 .…”