Triterpenoids and Iridoid Glycosides from <i>Gentiana dahurica</i>

Zang, Yi; Zhang, Yi; Zhang, Hongfeng; Zhao, Zheng; Hu, Jin‐Feng

doi:10.1002/hlca.201000095

Cited by 18 publications

(8 citation statements)

References 25 publications

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“…Gentiopicrin (CAS:20831-76-9), loganic acid (CAS: 22255-40-9), swertamarin (CAS: 1738839-5); loganin (CAS: 18524-94-2), vitexin (CAS: 3681-93-4), sweroside (CAS: 14215-86-2), and 6 -O-β-dglucopyranosylgentiopicroside (CAS: 115713-06-9) were purchased from Biopurify Phytochemicals Ltd. (Chengdu, China). The purity of all of the standards is higher than 98% (determined by HPLC), and were confirmed by the 1 H-NMR spectra to those in the literature [14][15][16][17][18][19][20].…”

Section: Plant Materials Reagents and Chemicalssupporting

confidence: 75%

“…Gentiopicroside, swertiamarin, 6 -O-β-d-glucopyranosyl-gentiopicroside, sweroside, loganic acide and loganin were identified by comparison with the retention time and mass fragmentation of reference standards. The SciFinder Scholar and the PubChem databases were searched for the spectral data of other compounds reported previously in the genus Gentiana and G. straminea to identify the constituents of the herb [14][15][16][17][18][19][20]. Forty-three of these were identified by comparing the retention times and mass spectrometry, which has already been summarized [21], including 20 iridoids, 16 secoiridoids, 8 flavonoids, 2 triterpenoids, 2 lignins, 2 alkaloids, and 2 saccharides (Table 1).…”

Section: Identification Of the Constituents In G Straminea By Uplc-qmentioning

confidence: 99%

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Traceability of Geographical Origin in Gentiana straminea by UPLC-Q Exactive Mass and Multivariate Analyses

et al. 2019

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The root of Gentiana straminea Maxim. (Gentianaceae), is officially listed as “Qin-Jiao” in the Chinese Pharmacopoeia for the treatment of rheumatic arthritis, icteric hepatitis, constipation, pain, and hypertension. To establish the geographical origin traceability in G. straminea, its chemical profiles were determined by a UPLC-Q exactive mass spectrometer, from which 43 compounds were identified by comparing retention times and mass spectrometry. Meanwhile, a pair of isomers (loganin and secologanol) was identified by mass spectrometry based on their fragmentation pathway. A total of 42 samples from difference habitats were determined by an UPLC-Q exactive mass spectrometer and the data were assayed with multivariate statistical analysis. Eight characteristic compounds were identified to determine the geographical origin of the herb. To estimate the key characteristic markers associated with pharmacological function, the inhibiting activities of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced macrophages were examined. This finding is crucial in realizing the determination of botanical origin and evaluating the quality of G. straminea.

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Section: Plant Materials Reagents and Chemicalssupporting

confidence: 75%

Section: Identification Of the Constituents In G Straminea By Uplc-qmentioning

confidence: 99%

Traceability of Geographical Origin in Gentiana straminea by UPLC-Q Exactive Mass and Multivariate Analyses

et al. 2019

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“…7 (11) 2012 1489 There are only a few reports regarding the cytotoxic activity of Gentiana spp. or the compounds that were tested in our study [27,28]. To our knowledge, this is the first report of the potent cytotoxic activity of gentiopicrin, mangiferin and isogentisin against the HeLa cell line.…”

mentioning

confidence: 87%

Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae Luteae Folium) Grown in Northern Regions of Montenegro

Balijagic

Janković

Zdunić

et al. 2012

Natural Product Communications

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LC-ESI-MS and HPLC were used for the identification of the constituents from G. lutea leaves collected at different localities, as well as for quantification of the main compounds. Seven secoiridoids, five C-glucoflavones and three xanthones, were identified. Swertiamarin derivatives, namely eustomorusside (2), eustomoside (3) and septemfidoside (5), were detected in G. lutea for the first time. Concentrations of five constituents (swertiamarin, gentiopicrin, isovitexin, mangiferin and isogentisin) were determined. The relationship between concentrations of γ-pyrones and altitude was observed with statistically significant correlation (r = 0.94). The extracts were also evaluated for their content of total phenolics, and antiradical and cytotoxic activities. The total phenolics content ranged from 7.7 to 12.7 mg GAE/g, and the IC 50 values for DPPH radical scavenging activity varied between 0.45 to 2.02 mg/mL. The leaf extract exhibited moderate cytotoxic effects toward HeLa cells with an IC 50 value of 41.1 µg/mL, while gentiopicrin, mangiferin and isogentisin exerted strong activity against HeLa cells, with IC 50 values ranging from 5.7 to 8.8 µg/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents.

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“…In a study on the two new methods, iridoid glycosides were isolated from the roots of G. dahurica , in order to elucidate the chemical characteristics of the hydrolysis product. HPLC-ELSD was employed for the detection of d -glucose [ 77 ]. The purity of polysaccharide was tested by HPLC-RID [ 95 ].…”

Section: Methodsmentioning

confidence: 99%

Analytical Methods of Phytochemicals from the Genus Gentiana

Liu

Maffucci

et al. 2017

Molecules

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The genus Gentiana comprises approximately 400 species. Many species have a wide range of pharmacological activities and have been used therapeutically for thousands of years. To provide comprehensive guidance, utilization and quality control of Gentiana species, this review presents updated information concerning the recent application and progress of chemical analysis including phytochemical analysis, sample preparation and chemometrics. Detailed and comprehensive data including number of analytes, extraction/separation methods, analytical techniques and chemometrics are shown as corresponding tables. These data illustrate that the development of newly discovered compounds and therapeutic uses, understanding of the structure—activity relationship and establishment of harmonious and effective medicinal herb standards are the direction of advancement in future research.

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Triterpenoids and Iridoid Glycosides from Gentiana dahurica

Cited by 18 publications

References 25 publications

Traceability of Geographical Origin in Gentiana straminea by UPLC-Q Exactive Mass and Multivariate Analyses

Traceability of Geographical Origin in Gentiana straminea by UPLC-Q Exactive Mass and Multivariate Analyses

Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae Luteae Folium) Grown in Northern Regions of Montenegro

Analytical Methods of Phytochemicals from the Genus Gentiana

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