Triterpenoid Saponins from <i>Pulsatilla cernua</i> (Thunb.) Bercht. et Opiz.

Tian, Xu; Xu, Yun; Han, Dong; Zhao, Huanxin; Xie, Shengxu; Xu, Dongming

doi:10.1111/j.1744-7909.2007.00339.x

Cited by 10 publications

(5 citation statements)

References 7 publications

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“…Previous studies have confirmed that anemoside B 4 and anemonin are isolated from root of Radix Pulsatilla. 1,2 The biological activities of anemoside B 4 and anemonin include hepatic protective, anti-inflammatory, and anti-tumor effects. Rhizoma Coptidis [3][4][5][6][7][8] contain berberine, jateorhizine, and palmatine in their barks.…”

Section: Introductionmentioning

confidence: 99%

Pulsatilla decoction and its active ingredients inhibit secretion of NO, ET‐1, TNF‐α, and IL‐1α in LPS‐induced rat intestinal microvascular endothelial cells

Hu¹,

Chen²,

Duan³

et al. 2009

Cell Biochemistry & Function

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To investigate the pharmacological mechanism of the traditional Chinese medicine, Pulsatilla decoction (PD), the levels of nitric oxide (NO), endothelin-1 (ET-1), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha) secreted by cultured rat intestinal microvascular endothelial cells (RIMECs) were determined after treatment with PD and its seven active ingredients, namely anemoside B(4), anemonin, berberine, jatrorrhizine, palmatine, aesculin, and esculetin. RIMECs were challenged with lipopolysaccharide (LPS) at 1 microg ml(-1) for 3 h and then treated with PD at 1, 5, and 10 mg ml(-1) and its seven ingredients at 1, 5, and 10 microg ml(-1) for 21 h, respectively. The results revealed that PD, anemonin, berberine, and esculetin inhibited the production of NO; PD, anemonin, and esculetin inhibited the secretion of ET-1; PD, anemoside B(4), berberine, jatrorrhizine, and aesculin downregulated TNF-alpha expression; PD, anemoside B(4), berberine, and palmatine decreased the content of IL-1 alpha. It showed that PD and its active ingredients could significantly inhibit the secretion of NO, ET-1, TNF-alpha, and IL-1 alpha in LPS-induced RIMECs and suggested they would reduce inflammatory response via these cytokines.

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Section: Introductionmentioning

confidence: 99%

Pulsatilla decoction and its active ingredients inhibit secretion of NO, ET‐1, TNF‐α, and IL‐1α in LPS‐induced rat intestinal microvascular endothelial cells

Hu¹,

Chen²,

Duan³

et al. 2009

Cell Biochemistry & Function

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“…Accordingly, the structure of compound 1 was elucidated as 3β Table 1). The aglycone of 2 was identified as oleanolic acid by extensive 2D NMR studies [16]. Table 1).…”

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confidence: 99%

Cytotoxic Triterpenoid Saponins from the Rhizomes ofAnemone taipaiensis

Wang

Chen²,

Tang³

et al. 2011

Planta Med

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Two new oleanane-type triterpenoid saponins, 1 and 2, and a new natural product, 3, together with five known saponins, 4- 8, were isolated from the rhizomes of ANEMONE TAIPAIENSIS. Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. Six saponins, 1, 2, 4- 7, which possessed a free carboxylic group at C-28, exhibited significant cytotoxicity against human leukemia HL-60 cells and human hepatocellular carcinoma Hep-G2 cells with IC (50) values in the range of 1.31-10.12 µM.

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“…The roots are used for the treatment of amoebic dysentery, malaria and chills [1]. Previous phytochemical investigations on this plant have reported a number of triterpenoid saponins [1,2,3,4,5,6,7,8,9]. Modern researches have shown that the chemical components of P. cernua had strong biological activities, and especially the saponin-enriched fraction with some active components showing remarkable effects in the treatment of Alzheimer’s disease (AD) [10,11].…”

Section: Introductionmentioning

confidence: 99%

Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua

et al. 2012

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Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is reported for the first time from this genus. Some of these compounds showed significant neuroprotective effects against the cytotoxicity induced by β-amyloid 25-35 (Aβ 25-35 ) on human neuroblastoma SH-SY5Y cells.

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Triterpenoid Saponins from Pulsatilla cernua (Thunb.) Bercht. et Opiz.

Abstract: To investigate saponins from the roots of Pulsatilla cernua (Thunb.) Bercht. et Opiz., two new compounds together with five known triterpenoid saponins were isolated. The structures of the two new triterpenoid saponins, named cernuasides A and B, were elucidated as 3-O

Cited by 10 publications

References 7 publications

Pulsatilla decoction and its active ingredients inhibit secretion of NO, ET‐1, TNF‐α, and IL‐1α in LPS‐induced rat intestinal microvascular endothelial cells

Pulsatilla decoction and its active ingredients inhibit secretion of NO, ET‐1, TNF‐α, and IL‐1α in LPS‐induced rat intestinal microvascular endothelial cells

Cytotoxic Triterpenoid Saponins from the Rhizomes ofAnemone taipaiensis

Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua

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