Triterpenoid Saponins from<i>Androsace umbellata</i>and their Anti-proliferative Activities in Human Hepatoma Cells

Wang, Ying; Zhang, Dongmei; Ye, Wen‐Cai; Yin, Zhiqi; Fung, Kwok‐Pui; Zhao, Shouxue; Yao, Xin‐Sheng

doi:10.1055/s-2008-1081291

Cited by 22 publications

(12 citation statements)

References 12 publications

(17 reference statements)

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“…Studies have also reported that kaempferol and quercetin modulate the inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), reactive C-protein (CRP), and nuclear factor kappa B (NF-jB) (García-Mediavilla et al, 2007). Other studies have shown that oleanolic acid and saponins possess anti-inflammatory, (Giner-Larza et al, 2001;Wang, Gao, Kou, Zhu, & Yu, 2008) and antitumoral properties (Chen et al, 2008;Wang, Zhang et al, 2008).…”

Section: Introductionmentioning

confidence: 95%

Evaluation of the anti-inflammatory efficacy of Lotus corniculatus

et al. 2009

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Section: Introductionmentioning

confidence: 95%

Evaluation of the anti-inflammatory efficacy of Lotus corniculatus

et al. 2009

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“…primulanin, saxifragifolin B, C and D were found to exert cytotoxity in the aforementioned liver cancer cell lines although the mechanisms of such effects were not elucidated [112] . A new triterpene compound, 20(R), 22(ζ), 24(S)-dammar-25(26)-ene-3β, 6α, 12β, 20, 22, 24-hexanol, and three known triterpenoids, β-D-glucopyranoside,(3β,12β)-12,20-dihydroxydammar-24-en-3-yl,6-acetate, 20(R)ginsenoside Rg3, and 20(R)-ginsenoside Rh2, isolated from the leaves of Panax ginseng, exhibited various degrees of cytoxicity against HepG2 cells through p53-mediated cell cycle arrest and apoptosis via activation of the caspase signaling pathway [113] .…”

Section: Lupeolmentioning

confidence: 99%

“…Wang et al [112] Exhibited cytotoxicity against HepG2 cells ↑apoptosis; ↑p53; ⊥G1/S 0.5-80 μmol/L Huang et al [113] Tetraterpenes Astaxanthin, β-Carotene…”

Section: Lupeolmentioning

confidence: 99%

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Thoppil

Bishayee²

2011

WJH

278

143

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Despite significant advances in medicine, liver cancer, predominantly hepatocellular carcinoma remains a major cause of death in the United States as well as the rest of the world. As limited treatment options are currently available to patients with liver cancer, novel preventive control and effective therapeutic approaches are considered to be reasonable and decisive measures to combat this disease. Several naturally occurring dietary and non-dietary phytochemicals have shown enormous potential in the prevention and treatment of several cancers, especially those of the gastrointestinal tract. Terpenoids, the largest group of phytochemicals, traditionally used for medicinal purposes in India and China, are currently being explored as anticancer agents in clinical trials. Terpenoids (also called "isoprenoids") are secondary metabolites occurring in most organisms, particularly plants. More than 40 000 individual terpenoids are known to exist in nature with new compounds being discovered every year. A large number of terpenoids exhibit cytotoxicity against a variety of tumor cells and cancer preventive as well as anticancer efficacy in preclinical animal models. This review critically examines the potential role of naturally occurring terpenoids, from diverse origins, in the chemoprevention and treatment of liver tumors. Both in vitro and in vivo effects of these agents and related cellular and molecular mechanisms are highlighted. Potential challenges and future directions involved in the advancement of these promising natural compounds in the chemoprevention and therapy of human liver cancer are also discussed.

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“…Its whole plant or fruit has been used as a traditional Chinese medicine for analgesic, antiphlogistic and the treatment of sore throat (Zhonghuabencao compilation committee, 1999). Previous phytochemical and pharmacological investigations on A. umbellata revealed the presence of seven triterpenoid saponins, three flavonoids and daucosterol (Li et al, 2008;Wang et al, 2008), and an apoptosisinducing saponin (Zhang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic effects of triterpenoid saponins from Androsace umbellata against multidrug resistance (MDR) and non-MDR cells

et al. 2010

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Cytotoxicity-guided fractionation and separation of MeOH extract from Androsace umbellata (Lour.) Merr. led to the isolation of four triterpenoid saponins. Compounds isolated from the n-BuOH soluble fraction were identified as saxifragifolin C (1), A (2), B (3), and D (4) by spectroscopic analysis. Antiproliferative effect of isolated compounds were evaluated by the sulforhodamin B assay against multidrug resistance (MDR; MES-SA/DX5 and HCT15/CLO2) and non-MDR (A549, SK-OV-3, SK-MEL-2, MES-SA, and HCT15) human tumor cell lines. All compounds exhibited strong cytotoxicity against non-MDR human tumor cell lines with IC(50) values of 0.19-2.37 muM. MDR cells and non-MDR cells had similar sensitivity to these compounds, however, MDR cells were highly resistant to doxorubicin. Compounds 1-4 induced an increase in the percentage of Annexin V-binding cells, indicating that 1-4 induced apoptosis in RAW 264.7 cells. Also, the condensation of nuclei, a characteristic morphological change of apoptosis, was observed in RAW 264.7 cells by the treatment with n-BuOH fraction, compounds 3 and 4, respectively.

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Triterpenoid Saponins fromAndrosace umbellataand their Anti-proliferative Activities in Human Hepatoma Cells

Cited by 22 publications

References 12 publications

Evaluation of the anti-inflammatory efficacy of Lotus corniculatus

Evaluation of the anti-inflammatory efficacy of Lotus corniculatus

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Cytotoxic effects of triterpenoid saponins from Androsace umbellata against multidrug resistance (MDR) and non-MDR cells

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