Triterpenoid glycosides from the bark of Mimosa tenuiflora

Jiang, Yanwei; Massiot, Georges; Lavaud, Catherine; Teulon, Jean‐Marie; Guéchot, Christophe; Haag–Berrurier, M.; Anton, Robert

doi:10.1016/0031-9422(91)83648-5

Cited by 35 publications

(19 citation statements)

References 6 publications

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“…There are, to our knowledge, no previous studies in the literature presenting antivenom activity of extracts from M. tenuiflora ; however, it is known that there is a significant presence of saponins in this species [18, 21, 29]. One hypothesis for this activity is the inhibition of the production of leukotrienes and prostaglandin E2 by inhibiting the enzyme phospholipase A2 and COX2, respectively, as well as blocking the release of all other inflammatory mediators involved in the venoming, as studies being conducted in parallel to our laboratory previously demonstrated the anti-inflammatory potential of M. tenuiflora in experimental models of inflammation using carrageenan.…”

Section: Discussionmentioning

confidence: 99%

Neutralizing Effects ofMimosa tenuifloraExtracts against Inflammation Caused byTityus serrulatusScorpion Venom

Bitencourt

Lima

Torres-Rêgo

et al. 2014

BioMed Research International

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Scorpion bite represents a significant and serious public health problem in certain regions of Brazil, as well as in other parts of the world. Inflammatory mediators are thought to be involved in the systemic and local immune response induced by Tityus serrulatus scorpion envenomation. The aim of this study was to evaluate the effect of extracts of Mimosa tenuiflora on model envenomation. In mice, the envenomation model is induced by Tityus serrulatus venom. Previous treatment of mice with fractions from M. tenuiflora was able to suppress the cell migration to the peritoneal cavity. The treatment of mice with M. tenuiflora extracts also decreased the levels of IL-6, IL-12, and IL-1β. We concluded that the administration of the extract and fractions resulted in a reduction in cell migration and showed a reduction in the level of proinflammatory cytokines. This study demonstrates, for the first time, the anti-inflammatory effect of aqueous extract from the Mimosa tenuiflora plant on T. serrulatus venom.

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Section: Discussionmentioning

confidence: 99%

Neutralizing Effects ofMimosa tenuifloraExtracts against Inflammation Caused byTityus serrulatusScorpion Venom

Bitencourt

Lima

Torres-Rêgo

et al. 2014

BioMed Research International

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“…Research efforts had already identified both M. hostilis and M. tenuiflora as a source of N,N-dimethyltryptamine (DMT), which is a potent, psychoactive serotonin agonist [5], [6]. Other phytochemical analyses have also identified the presence of triterpenoid glycosides (saponins) in the root bark of M. tenuiflora, which may help promote damaged skin growth as a topical ointment in folk medicine [7].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Yuremamine, a New Phytoindole

et al. 2005

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“…Three saponins have also been identified: mimonoside A, mimonoside B, and mimonoside C (Fig. 4) (Anton et al, 1993;Jiang et al, 1991a;Jiang et al, 1992). Anton et al (1993) recorded the presence of the triterpenoid lupeol.…”

Section: Steroids and Terpenoidsmentioning

confidence: 99%