Triterpenes of Croton betulaster (Euphorbiaceae)

Barbosa, Pedro; Fascio, Miguel; Martins, Dirceu; Guédès, Michel; Roque, Nı́dia Franca

doi:10.1016/s0305-1978(02)00145-x

Cited by 26 publications

(22 citation statements)

References 5 publications

(2 reference statements)

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“…77 From leaves of C. betulaster Müell. Arg., a species from northeast Brazil, Barbosa et al 106 obtained the triterpenes lupenone, lupeol, 3-oxo-22-hydroxyhopane, 3-oxo-20-β-hydroxytaraxastane, 3-oxo-20-hydroxylupane, 3-oxo-olean-12-en-28-oic acid, 3-oxoolean-18-en-28-oic acid, and 3-oxo-cycloart-24E-en-26-oic acid. The triterpene acetyl aleuritolic acid (12) has been obtained from two Croton species native in Brazil, C. cajucara 49,50 and C. urucurana.…”

Section: Pentacyclic Triterpenoids and Steroidsmentioning

confidence: 99%

“…24 From leaves of C. betulaster Müll. Arg., Barbosa et al 106 obtained 5-hydroxy,7,4'-dimethoxyflavone, and from leaves of C. hovarum Leandri, Krebs and Ramiarantsoa 62 isolated the flavone C-glycoside vitexin (21). From leaves and stems of C. brasiliensis, Palmeira et al 59 isolated the 3- 128 Flavonoid data is still too scarce to establish a pattern for Croton.…”

Section: Flavonoids and Other Phenolic Substancesmentioning

confidence: 99%

See 1 more Smart Citation

Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

Salatino¹,

Salatino²,

Negri³

2007

J. Braz. Chem. Soc.

374

308

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Croton é um gênero de Euphorbiaceae com cerca de 1300 espécies, amplamente distribuídas em regiões tropicais do Novo e Velho Mundos. Várias espécies há muito tempo desempenham papel importante nos usos tradicionais de plantas medicinais na África, Ásia e América do Sul. Tais usos incluem tratamento de câncer, constipação intestinal, diarréia e outros problemas digestivos, diabetes, feridas externas, febre, hipercolesterolemia, hipertensão, inflamação, vermes intestinais, malária, dor, úlceras e obesidade. Várias espécies de Croton têm um látex vermelho que contém, em algumas espécies, pró-antocianidinas e/ou alcalóides. Os alcalóides de Croton são a taspina ou substâncias relacionadas a benzilisoquinolinas. Os diterpenos são muito comuns em Croton, correspondendo a clerodanos, cembranóides, halimanos, cauranos, labdanos, ésteres do forbol, traquilobanos e sarcopetalanos. Algumas espécies são aromáticas, devido à presença de óleos voláteis. Representantes de novas classes de substâncias (fenilbutanóides, alcalóides glutarimidínicos e diterpenos sarcopetalanos) têm sido isoladas de espécies de Croton. Enquanto laticíferos têm sido descritos em espécies de Croton, até o momento não há estudos anatômicos sobre estruturas secretoras de óleos voláteis. Parece haver afinidades químicas no gênero relacionadas à geografia, agrupando espécies com (i) cauranos e/ou labdanos, (ii) traquilobanos e (iii) alcalóides. Os ensaios farmacológicos freqüentemente vêm corroborando os usos tradicionais de espécies de Croton. Grande parte dos ensaios farmacológicos trata do clerodano trans-desidrocrotonina, envolvendo uma grande diversidade de efeitos, incluindo hipolipidêmico, hipoglicêmico, antiestrogênico e anticâncer. Efeitos citotóxicos também vêm sendo observados em ensaios com alcalóides (taspina) e com diterpenóides secocaurenos, labdanos e cembranóides. Vários outros efeitos de substâncias de Croton têm sido relatados, incluindo anti-hipertensivos, antiinflamatórios, antimaláricos, antimicrobianos, antiespasmódicos, antiulcerogênicos, antivirais e mio-relaxantes.Croton is a genus of Euphorbiaceae comprising around 1,300 species, widespread in tropical regions of the Old and New Worlds. Several species have a long role in the traditional use of medicinal plants in Africa, Asia and South America. Popular uses include treatment of cancer, constipation, diabetes, digestive problems, dysentery, external wounds, fever, hypercholesterolemia, hypertension, inflammation, intestinal worms, malaria, pain, ulcers and weight-loss. Several species of Croton have a red sap, in some species containing proanthocyanidins and/or alkaloids. The latter may be taspine or some of several benzylisoquinoline-like compounds. Diterpenes are very common in Croton, corresponding to clerodanes, cembranoid, halimanes, kauranes, labdanes, phorbol esters, trachylobanes and sarcopetalanes. Some species are aromatic due to the possession of volatile oils. Representatives of new classes of compounds (phenylbutanoids, glutarimide alkaloids, sarcopetalane diterpen...

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Section: Pentacyclic Triterpenoids and Steroidsmentioning

confidence: 99%

Section: Flavonoids and Other Phenolic Substancesmentioning

confidence: 99%

Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

Salatino¹,

Salatino²,

Negri³

2007

J. Braz. Chem. Soc.

374

308

View full text Add to dashboard Cite

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“…Thus, accurately weighed 200 mg portions of each CE of 'aroeira', 'bardana', 'catuaba', 'chá-verde', 'marapuama', 'nó-de-cachorro', 'tansagem', 'marcela'; 100 mg CE of 'guaco', and 50 mg CE of 'uva-ursi' were dissolved in 500 μL water. All extracts were mixed in a tube shaker, and extracted with 500 μL of ethyl acetate (except for n-hexane in the case of 'marapuama'; Barbosa et al, 2003) in a microtiter shaker at 1400 rpm (IKA, MS1 Minishaker) for 5 min. Then, the tubes were placed in a refrigerated microcentrifuge (Eppendorf, Centrifuge 5415R), at 4000 x g for 4 min at 5 ºC, for the total separation of the phases.…”

Section: Preparation Of Final Solutions For Chromatographic Analysismentioning

confidence: 99%

Quality control and TLC profile data on selected plant species commonly found in the Brazilian market

Braz¹,

Wolf²,

Lopes³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The use of thin-layer chromatography (TLC) is a commonplace practice and can be of signifi cant help to different laboratories with quality control, especially those that work with plant extracts and phytotherapeutics. This study evaluated ten species of plants (Schinus terebinthifolius, Arctium lappa, Trichilia catigua, Camellia sinensis, Mikania glomerata, Croton moritibensis, Achyrocline satureioides, Heteropterys aphrodisiaca, Plantago major, Arctostaphylos uva-ursi) that are commonly sold by compounding pharmacies, using TLC with reference substances and pharmacopoeic physical and chemical tests (loss on drying, level of extractives, and total ash content). The results showed that the ten species showed losses on drying consonant with the literature. The level of extractives for two species and total ash for fi ve species were also consonant with the literature, and those of the other species were established in this study. The semipurifi ed extracts of the ten species were assayed by TLC, and the analysis with the use of reference substances proved to be effective, in addition to being practical, simple, versatile, and economically viable.

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“…4 They also produced triterpenes, 5 sesquiterpenes, monoterpenes, 6 flavonoids 7 and other metabolites. In a previous work we described the isolation of triterpenes from Croton betulaster 8 and flavonoids from both C. betulaster and C. luetzelburgii 9 but diterpenes and alkaloids were not found in these plants. Now, we describe three new benzoyl-methylpolyols isolated from Croton betulaster and C. luetzelburgii collected at Chapada Diamantina.…”

Section: Introductionmentioning

confidence: 97%